Cortical microstructure in primary progressive aphasia: a multicenter study
Por:
Illan-Gala, I, Montal, V, Borrego-Ecija, S, Mandelli, ML, Falgas, N, Welch, AE, Pegueroles, J, Santos-Santos, M, Bejanin, A, Alcolea, D, Dols-Icardo, O, Belbin, O, Sanchez-Saudinos, MB, Bargallo, N, Gonzalez-Ortiz, S, Llado, A, Blesa, R, Dickerson, BC, Rosen, HJ, Miller, BL, Lleo, A, Gorno-Tempini, ML, Sanchez-Valle, R, Fortea, J
Publicada:
9 feb 2022
Resumen:
Background: Cortical mean diffusivity is a novel imaging metric sensitive to early changes in neurodegenerative syndromes. Higher cortical mean diffusivity values reflect microstructural disorganization and have been proposed as a sensitive biomarker that might antedate macroscopic cortical changes. We aimed to test the hypothesis that cortical mean diffusivity is more sensitive than cortical thickness to detect cortical changes in primary progressive aphasia (PPA).
Methods: In this multicenter, case-control study, we recruited 120 patients with PPA (52 non-fluent, 31 semantic, and 32 logopenic variants; and 5 GRN-related PPA) as well as 89 controls from three centers. The 3-Tesla MRI protocol included structural and diffusion-weighted sequences. Disease severity was assessed with the Clinical Dementia Rating scale. Cortical thickness and cortical mean diffusivity were computed using a surface-based approach.
Results: The comparison between each PPA variant and controls revealed cortical mean diffusivity increases and cortical thinning in overlapping regions, reflecting the canonical loci of neurodegeneration of each variant. Importantly, cortical mean diffusivity increases also expanded to other PPA-related areas and correlated with disease severity in all PPA groups. Cortical mean diffusivity was also increased in patients with very mild PPA when only minimal cortical thinning was observed and showed a good correlation with measures of disease severity.
Conclusions: Cortical mean diffusivity shows promise as a sensitive biomarker for the study of the neurodegeneration-related microstructural changes in PPA.
Filiaciones:
Illan-Gala, I:
Hosp Santa Creu & Sant Pau, Biomed Res Inst St Pau, Dept Neurol, Memory Unit, St Antoni Maria Claret 167, Barcelona 08025, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Univ Calif San Francisco, Atlantic Fellow Equ Brain Hlth, San Francisco, CA 94115 USA
Montal, V:
Hosp Santa Creu & Sant Pau, Biomed Res Inst St Pau, Dept Neurol, Memory Unit, St Antoni Maria Claret 167, Barcelona 08025, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Borrego-Ecija, S:
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Univ Barcelona, Hosp Clin Barcelona, Inst Invest Biomed August Pi i Sunyer, Alzheimers Dis & Other Cognit Disorders Unit,Serv, Barcelona 08036, Spain
Mandelli, ML:
Univ Calif San Francisco, Memory & Aging Ctr, Dept Neurol, San Francisco, CA 94115 USA
Falgas, N:
Univ Calif San Francisco, Atlantic Fellow Equ Brain Hlth, San Francisco, CA 94115 USA
Univ Calif San Francisco, Memory & Aging Ctr, Dept Neurol, San Francisco, CA 94115 USA
Welch, AE:
Univ Calif San Francisco, Memory & Aging Ctr, Dept Neurol, San Francisco, CA 94115 USA
Pegueroles, J:
Hosp Santa Creu & Sant Pau, Biomed Res Inst St Pau, Dept Neurol, Memory Unit, St Antoni Maria Claret 167, Barcelona 08025, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Santos-Santos, M:
Hosp Santa Creu & Sant Pau, Biomed Res Inst St Pau, Dept Neurol, Memory Unit, St Antoni Maria Claret 167, Barcelona 08025, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Bejanin, A:
Hosp Santa Creu & Sant Pau, Biomed Res Inst St Pau, Dept Neurol, Memory Unit, St Antoni Maria Claret 167, Barcelona 08025, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Alcolea, D:
Hosp Santa Creu & Sant Pau, Biomed Res Inst St Pau, Dept Neurol, Memory Unit, St Antoni Maria Claret 167, Barcelona 08025, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Dols-Icardo, O:
Hosp Santa Creu & Sant Pau, Biomed Res Inst St Pau, Dept Neurol, Memory Unit, St Antoni Maria Claret 167, Barcelona 08025, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Belbin, O:
Hosp Santa Creu & Sant Pau, Biomed Res Inst St Pau, Dept Neurol, Memory Unit, St Antoni Maria Claret 167, Barcelona 08025, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Sanchez-Saudinos, MB:
Hosp Santa Creu & Sant Pau, Biomed Res Inst St Pau, Dept Neurol, Memory Unit, St Antoni Maria Claret 167, Barcelona 08025, Spain
Bargallo, N:
Hosp Clin Barcelona & Magnet Resonance Image Core, Inst Invest Biomed August Pi i Sunye IDIBAPS, Radiol Dept, Barcelona, Spain
Gonzalez-Ortiz, S:
Hosp Mar, Dept Radiol, Barcelona, Spain
Llado, A:
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Univ Barcelona, Hosp Clin Barcelona, Inst Invest Biomed August Pi i Sunyer, Alzheimers Dis & Other Cognit Disorders Unit,Serv, Barcelona 08036, Spain
Blesa, R:
Hosp Santa Creu & Sant Pau, Biomed Res Inst St Pau, Dept Neurol, Memory Unit, St Antoni Maria Claret 167, Barcelona 08025, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Dickerson, BC:
Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA 02115 USA
Massachusetts Alzheimers Dis Res Ctr, Boston, MA USA
Rosen, HJ:
Univ Calif San Francisco, Memory & Aging Ctr, Dept Neurol, San Francisco, CA 94115 USA
Miller, BL:
Univ Calif San Francisco, Memory & Aging Ctr, Dept Neurol, San Francisco, CA 94115 USA
Lleo, A:
Hosp Santa Creu & Sant Pau, Biomed Res Inst St Pau, Dept Neurol, Memory Unit, St Antoni Maria Claret 167, Barcelona 08025, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Gorno-Tempini, ML:
Univ Calif San Francisco, Memory & Aging Ctr, Dept Neurol, San Francisco, CA 94115 USA
Sanchez-Valle, R:
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Univ Barcelona, Hosp Clin Barcelona, Inst Invest Biomed August Pi i Sunyer, Alzheimers Dis & Other Cognit Disorders Unit,Serv, Barcelona 08036, Spain
Fortea, J:
Hosp Santa Creu & Sant Pau, Biomed Res Inst St Pau, Dept Neurol, Memory Unit, St Antoni Maria Claret 167, Barcelona 08025, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Fundacio Catalana Sindrome Down, Barcelona Med Ctr, Barcelona, Spain
Green Published, gold, All Open Access, Gold, Green
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