Performance and complications of lumbar puncture in memory clinics: Results of the multicenter lumbar puncture feasibility study
Por:
Duits, FH, Martinez-Lage, P, Paquet, C, Engelborghs, S, Lleo, A, Hausner, L, Molinuevo, JL, Stomrud, E, Farotti, L, Ramakers, IHGB, Tsolaki, M, Skarsgard, C, Astrand, R, Wallin, A, Vyhnalek, M, Holmber-Clausen, M, Forlenza, OV, Ghezzi, L, Ingelsson, M, Hoff, EI, Roks, G, de Mendonca, A, Papma, JM, Izagirre, A, Taga, M, Struyfs, H, Alcolea, DA, Frolich, L, Balasa, M, Minthon, L, Twisk, JWR, Persson, S, Zetterberg, H, van der Flier, WM, Teunissen, CE, Scheltens, P, Blennow, K
Publicada:
1 feb 2016
Resumen:
Introduction: Lumbar puncture (LP) is increasingly performed in memory clinics. We investigated patient-acceptance of LP, incidence of and risk factors for post-LP complications in memory clinic populations.
Methods: We prospectively enrolled 3868 patients (50% women, age 66 +/- 11 years, mini mental state examination 25 +/- 5) at 23 memory clinics. We used logistic regression analysis using generalized estimated equations to investigate risk factors for post-LP complications, such as typical postlumbar puncture headache (PLPH) and back pain.
Results: A total of 1065 patients (31%) reported post-LP complaints; 589 patients (17%) reported back pain, 649 (19%) headache, of which 296 (9%) reported typical PLPH. Only few patients needed medical intervention: 11 (0.3%) received a blood patch, 23 (0.7%) were hospitalized. The most important risk factor for PLPH was medical history of headache. An atraumatic needle and age >65 years were preventive. Gender, rest after LP, or volume of cerebrospinal fluid had no effect.
Discussions: The overall risk of complications is relatively low. If risk factors shown in this study are taken into account, LPs can be safely performed in memory clinics. (C) 2016 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
Filiaciones:
Duits, FH:
Vrije Univ Amsterdam, Med Ctr, Alzheimer Ctr, Neurosci Campus Amsterdam, Amsterdam, Netherlands
Vrije Univ Amsterdam, Med Ctr, Dept Neurol, Neurosci Campus Amsterdam, Amsterdam, Netherlands
Martinez-Lage, P:
Alzheimer Fdn, Fdn CITA, Dept Neurol, San Sebastian, Spain
Paquet, C:
INSERM, U942, F-75654 Paris 13, France
Univ Paris Diderot, Sorbonne Paris Cite, UMRS 942, Paris, France
Hop Lariboisiere, AP HP, Res Memory Ctr Paris North, F-75475 Paris, France
Engelborghs, S:
Univ Antwerp, Inst Born Bunge, Reference Ctr Biol Markers Dementia BIODEM, B-2020 Antwerp, Belgium
Hosp Network Antwerp ZNA Middelheim & Hoge Beuken, Dept Neurol & Memory Clin, Antwerp, Belgium
Lleo, A:
Hosp Santa Creu & Sant Pau, Dept Neurol, Memory Unit, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Hausner, L:
Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Geriatr Psychiat, Heidelberg, Germany
Molinuevo, JL:
ICN Hosp Clin & Univ, Neurol Serv, Alzheimers Dis & Other Cognit Disorders Unit, Barcelona, Spain
Pasqual Maragall Fdn, Barcelona, Spain
Stomrud, E:
Lund Univ, Dept Clin Sci Malmo, Clin Memory Res Unit, Lund, Sweden
Farotti, L:
Univ Perugia, Neurol Clin, Ctr Disturbi Memoria, I-06100 Perugia, Italy
Ramakers, IHGB:
Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Alzheimer Ctr Limburg, NL-6200 MD Maastricht, Netherlands
Tsolaki, M:
Aristotle Univ Thessaloniki, Dept Neurol 3, Skopje, North Macedonia
Skarsgard, C:
Kalmar Cty Hosp, Dept Geriatr, Kalmar, Sweden
Astrand, R:
Karlstad Cent Hosp, Dept Cognit Med, Karlstad, Sweden
Wallin, A:
Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Memory Clin,Dept Neuropsychiat,Sahlgrenska Univ H, Molndal, Sweden
Vyhnalek, M:
Charles Univ Prague, Fac Med 2, Dept Neurol, Memory Clin, Prague, Czech Republic
Motol Univ Hosp, Prague, Czech Republic
St Annes Univ Hosp, Int Clin Res Ctr, Brno, Czech Republic
Holmber-Clausen, M:
Minnesmottagningen, Dept Geriatr, Eskilstuna, Sweden
Forlenza, OV:
Univ Sao Paulo, Dept & Inst Psychiat, Lab Neurosci LIM 27, Sao Paulo, Brazil
Ghezzi, L:
Univ Milan, Fdn Ca Grandam IRCCS Osped Policlin, Dept Pathophysiol & Transplantat, Neurol Unit, Milan, Italy
Ingelsson, M:
Uppsala Univ, Dept Publ Hlth & Caring Sci, Uppsala, Sweden
Hoff, EI:
Atrium Med Ctr Parkstad, Dept Neurol, Heerlen, Netherlands
Roks, G:
St Elizabeth Hosp, Dept Neurol, Tilburg, Netherlands
de Mendonca, A:
Univ Lisbon, Fac Med, Dept Mol Med, P-1699 Lisbon, Portugal
Papma, JM:
Erasmus MC Univ, Med Ctr, Dept Neurol, Rotterdam, Netherlands
Izagirre, A:
Alzheimer Fdn, Fdn CITA, Dept Neurol, San Sebastian, Spain
Taga, M:
INSERM, U942, F-75654 Paris 13, France
Univ Paris Diderot, Sorbonne Paris Cite, UMRS 942, Paris, France
Hop Lariboisiere, AP HP, Res Memory Ctr Paris North, F-75475 Paris, France
Struyfs, H:
Univ Antwerp, Inst Born Bunge, Reference Ctr Biol Markers Dementia BIODEM, B-2020 Antwerp, Belgium
Alcolea, DA:
Hosp Santa Creu & Sant Pau, Dept Neurol, Memory Unit, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Frolich, L:
Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Geriatr Psychiat, Heidelberg, Germany
Balasa, M:
ICN Hosp Clin & Univ, Neurol Serv, Alzheimers Dis & Other Cognit Disorders Unit, Barcelona, Spain
Pasqual Maragall Fdn, Barcelona, Spain
Minthon, L:
Lund Univ, Dept Clin Sci Malmo, Clin Memory Res Unit, Lund, Sweden
Twisk, JWR:
Vrije Univ Amsterdam, Med Ctr, Dept Epidemiol & Biostat, Amsterdam, Netherlands
Persson, S:
Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Clin Neurochem, Molndal, Sweden
Zetterberg, H:
Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Clin Neurochem, Molndal, Sweden
UCL Inst Neurol, Dept Mol Neurosci, London, England
van der Flier, WM:
Vrije Univ Amsterdam, Med Ctr, Alzheimer Ctr, Neurosci Campus Amsterdam, Amsterdam, Netherlands
Vrije Univ Amsterdam, Med Ctr, Dept Neurol, Neurosci Campus Amsterdam, Amsterdam, Netherlands
Vrije Univ Amsterdam, Med Ctr, Dept Epidemiol & Biostat, Amsterdam, Netherlands
Teunissen, CE:
Vrije Univ Amsterdam, Med Ctr, Dept Clin Chem, Neurochem Lab & Biobank, Neurosci Campus Amsterdam, Amsterdam, Netherlands
Scheltens, P:
Vrije Univ Amsterdam, Med Ctr, Alzheimer Ctr, Neurosci Campus Amsterdam, Amsterdam, Netherlands
Vrije Univ Amsterdam, Med Ctr, Dept Neurol, Neurosci Campus Amsterdam, Amsterdam, Netherlands
Green Accepted
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