Incidence, clinical and biological characteristics and outcome of secondary acute lymphoblastic leukemia after solid organ or hematologic malignancy
Por:
Kelleher, N, Garcia, O, Gallardo, D, Gonzalez-Campos, J, Hernandez-Rivas, JM, Montesinos, P, Sarra, J, Gil, C, Barba, P, Guardia, R, Brunet, S, Bernal, T, Martinez, MP, Abella, E, Bermudez, A, Sanchez-Delgado, M, Antonia, C, Gayoso, J, Calbacho, M, Ribera, JM
Publicada:
2 ene 2016
Resumen:
Acute lymphoblastic leukemia (ALL) following solid organ or hematologic malignancy (secondary ALL, s-ALL) is not well characterized. We analyzed the characteristics and outcome of patients with s-ALL and compared them with those of patients with de novo- ALL. Of 448 patients, 24 (5%) had previous neoplasia. Sixteen patients had received previous cytotoxic therapy (therapy-associated ALL, t-ALL), and eight had not (antecedent-malignancy ALL, am-ALL). Except for more advanced age in patients with s-ALL, no statistically significant differences were observed in WBC count, CNS involvement, immunophenotype or cytogenetics between the groups, nor in complete remission (t-ALL: 94%; am-ALL: 75%; de novo-ALL: 85%), 3-year remission duration (58%; 50%; 72%), overall survival (71%; 38%; 60%) or event-free survival (53%, 38%; 53%). Our study did not show poor clinical or cytogenetic features or inferior outcome in ALL patients with antecedent neoplastic disease, irrespective of the type of treatment received for the neoplasia.
Filiaciones:
Kelleher, N:
Hosp Doctor Josep Trueta, Dept Hematol, Inst Catala Oncol, Girona, Spain
Garcia, O:
Univ Autonoma Barcelona, Hosp Germans Trias & Pujol, Inst Catala Oncol, Hematol Dept,Jose Carreras Res Inst, Badalona, Spain
Gallardo, D:
Hosp Doctor Josep Trueta, Dept Hematol, Inst Catala Oncol, Girona, Spain
Gonzalez-Campos, J:
Hosp Univ Virgen del Rocio, Dept Hematol, Seville, Spain
Hernandez-Rivas, JM:
Univ Salamanca, CSIC Salamanca, Ctr Invest Canc, Hematol Dept,Hosp Univ Salamanca,IBCC, E-37008 Salamanca, Spain
Univ Salamanca, CSIC Salamanca, Ctr Invest Canc, Dept Hematol,IBSAL,IBCC, E-37008 Salamanca, Spain
Montesinos, P:
Hosp Univ & Politecn La Fe, Dept Hematol, Valencia, Spain
Sarra, J:
Hosp Duran & Reynals, Inst Catala Oncol, Lhospitalet De Llobregat, Spain
Gil, C:
Hosp Gen Univ Alicante, Dept Hematol, Alicante, Spain
Barba, P:
Hosp Valle De Hebron, Dept Hematol, Barcelona, Spain
Guardia, R:
Hosp Doctor Josep Trueta, Dept Hematol, Inst Catala Oncol, Girona, Spain
Brunet, S:
Hosp Santa Creu & Sant Pau, Dept Hematol, Barcelona, Spain
Bernal, T:
Hosp Cent Asturias, Dept Hematol, Oviedo, Spain
Martinez, MP:
Hosp Doce Octubre, Dept Hematol, Madrid, Spain
Abella, E:
Hosp del Mar, Dept Hematol, Barcelona, Spain
Bermudez, A:
Hosp Marques Valdecilla, Dept Hematol, Santander, Spain
Sanchez-Delgado, M:
Hosp Gen Univ Valencia, Dept Hematol, Valencia, Spain
Antonia, C:
Hosp Son Llatzer, Dept Hematol, Palma de Mallorca, Spain
Gayoso, J:
Hosp Gen Univ Gregorio Maranon IiGSM, Dept Hematol, Madrid, Spain
Calbacho, M:
Hosp Ramon & Cajal, Dept Hematol, E-28034 Madrid, Spain
Ribera, JM:
Univ Autonoma Barcelona, Hosp Germans Trias & Pujol, Inst Catala Oncol, Hematol Dept,Jose Carreras Res Inst, Badalona, Spain
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