Total body-surface area as a new prognostic variable in mycosis fungoides and Sezary syndrome
Por:
Novelli, S, Garcia-Muret, P, Mozos, A, Sierra, J, Briones, J
Publicada:
1 ene 2016
Resumen:
Mycosis fungoides and Sezary syndrome (MF/SS) are the most common forms of primary cutaneous T cell lymphomas. We analyzed the applicability of the cutaneous lymphoma international prognostic index (CLIPi) in MF/SS. We introduced the total body-surface area affected (TBSA) and the type of skin lesions at diagnosis as prognostic variables. The overall survival (OS) at median time of follow up (96 months) was 75.6% (CI 95%, 62.0-98.5%). In the univariate analysis, age>60 years, advanced disease, type of skin lesions and TBSA>50 showed poorer OS (p<0.05). In the multivariate analysis there was a significant increased relative risk of death in those patients>60 years, with advanced disease and TBSA>50% (p<0.05). TBSA identified a group of poor prognosis patients with advanced MF/SS that may benefit from novel systemic therapies.
Filiaciones:
Novelli, S:
Hosp Santa Creu & Sant Pau, Hematol Serv, Carrer Mas Casanovas 90, Barcelona 08041, Spain
Garcia-Muret, P:
Hosp Santa Creu & Sant Pau, Dept Dermatol, Barcelona 08041, Spain
Mozos, A:
Hosp Santa Creu & Sant Pau, Dept Pathol, Barcelona 08041, Spain
Sierra, J:
Hosp Santa Creu & Sant Pau, Hematol Serv, Carrer Mas Casanovas 90, Barcelona 08041, Spain
Briones, J:
Hosp Santa Creu & Sant Pau, Hematol Serv, Carrer Mas Casanovas 90, Barcelona 08041, Spain
|