Clinical practice guidelines for the diagnosis and treatment of patients with soft tissue sarcoma by the Spanish group for research in sarcomas (GEIS)
Por:
del Muro, XG, de Alava, E, Artigas, V, Bague, S, Brana, A, Cubedo, R, Cruz, J, Mulet-Margalef, N, Narvaez, JA, Tirado, OM, Valverde, C, Verges, R, Vinals, J, Martin-Broto, J
Publicada:
1 ene 2016
Resumen:
Soft tissue sarcomas (STS) constitute an uncommon and heterogeneous group of tumours, which require a complex and specialized multidisciplinary management. The diagnostic approach should include imaging studies and core needle biopsy performed prior to undertaking surgery. Wide excision is the mainstay of treatment for localized sarcoma, and associated preoperative or postoperative radiotherapy should be administered in high-risk patients. Adjuvant chemotherapy was associated with a modest improvement in survival in a meta-analysis and constitutes a standard option in selected patients with high-risk STS. In metastatic patients, surgery must be evaluated in selected cases. In the rest of patients, chemotherapy and, in some subtypes, targeted therapy often used in a sequential strategy constitutes the treatment of election. Despite important advances in the understanding of the pathophysiology of the disease, the advances achieved in therapeutic results may be deemed still insufficient. Moreover, due to the rarity and complexity of the disease, the results in clinical practice are not always optimal. For this reason, the Spanish Group for Research on Sarcoma (GEIS) has developed a multidisciplinary clinical practice guidelines document, with the aim of facilitating the diagnosis and treatment of these patients in Spain. In the document, each practical recommendation is accompanied by level of evidence and grade of recommendation on the basis of the available data.
Filiaciones:
del Muro, XG:
Inst Catala Oncol Hosp, Barcelona, Spain
de Alava, E:
Hosp Univ Virgen del Rocio, Seville, Spain
Artigas, V:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Bague, S:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Brana, A:
Univ Oviedo, Hosp Cent Asturias, E-33080 Oviedo, Spain
Cubedo, R:
Hosp Puerta Hierro Majadahonda, Madrid, Spain
Cruz, J:
Hosp Univ Canarias, Santa Cruz De Tenerife, Spain
Mulet-Margalef, N:
Inst Catala Oncol Hosp, Barcelona, Spain
Narvaez, JA:
Hosp Univ Bellvitge, Barcelona, Spain
Tirado, OM:
Inst Invest Biomed Bellvitge IDIBELL, Barcelona, Spain
Valverde, C:
Hosp Univ Vall Hebron, Barcelona, Spain
Verges, R:
Hosp Univ Vall Hebron, Barcelona, Spain
Vinals, J:
Hosp Univ Bellvitge, Barcelona, Spain
Martin-Broto, J:
Hosp Univ Virgen del Rocio, Seville, Spain
Green Published, Hybrid Gold
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