Nailfold capillaroscopic findings in primary Sjogren's syndrome with and without Raynaud's phenomenon and/or positive anti-SSA/Ro and anti-SSB/La antibodies
Por:
Corominas, H, Ortiz-Santamaria, V, Castellvi, I, Moreno, M, Morla, R, Clavaguera, T, Erra, A, Martinez-Pardo, S, Ordonez, S, Santo, P, Reyner, P, Gonzalez, MJ, Codina, O, Gelman, MS, Juanola-Roura, X, Olive, A, Torrente-Segarra, V
Publicada:
1 mar 2016
Resumen:
The aim of this study was to assess nailfold capillaroscopic (NC) findings in patients with primary Sjogren's syndrome (PSS) with and without Raynaud's phenomenon (RP) as well as in the presence of positive anti-SSA/Ro and anti-SSB/La antibodies. Videocapillaroscopy was performed in 150 patients with PSS. Data collected included demographics, presence of RP, PSS symptoms, antinuclear antibodies, rheumatoid factor, anti-Ro, anti-La, anti-CCP, salivary scintigraphy, labial biopsy, and NC findings. RP was present in 32 % of PSS, keratoconjunctivitis sicca in 91 %, oral xerosis in 93 %, and skin or genital xerosis in 53 %. In patients with positive anti-SSA/Ro (75 %) and positive anti-SSB/La (40 %), NC showed normal findings in 53 % of cases and nonspecific in 36 %. In patients with PSS, NC was normal in 51 % of cases and non-specific in 34 %. Scleroderma pattern was found in 14 patients. RP associated with PSS had non-specific capillaroscopy in 40 % of cases (p = 0.1). Pericapillary haemorrhages (p = 0.06) and capillary thrombosis (p = 0.2) were not increased, but more dilated capillaries were detected in 48 % of cases. Patients with positive anti-Ro and/or anti-La have not a distinct NC profile. Patients with RP associated with PSS had more dilated capillaries, but neither pericapillary haemorrhages nor capillary thrombosis was observed.
Filiaciones:
Corominas, H:
Hosp St Joan Despi Moises Broggi, Hosp Gen Hosp, Serv Rheumatol, CSI, Avda Jacint Verdaguer 90, Barcelona 08970, Catalonia, Spain
Ortiz-Santamaria, V:
Hosp Granollers, Serv Rheumatol, Barcelona, Spain
Castellvi, I:
Univ Autonoma Barcelona, Hosp Univ St Pau, Serv Rheumatol, E-08193 Barcelona, Spain
Moreno, M:
Hosp Corporacio Parc Tauli, Serv Rheumatol, Barcelona, Spain
Morla, R:
Hosp Vendrell, Serv Rheumatol, Tarragona, Spain
Clavaguera, T:
Hosp Palamos, Serv Rheumatol, Palamos, Girona, Spain
Erra, A:
Hosp St Rafael, Serv Rheumatol, Barcelona, Spain
Martinez-Pardo, S:
Hosp Univ Mutua Terrassa, Serv Rheumatol, Barcelona, Spain
Ordonez, S:
Hosp Arnau Vilanova, Serv Rheumatol, Lleida, Spain
Santo, P:
Hosp Univ Bellvitge, Serv Rheumatol, Barcelona, Spain
Reyner, P:
Hosp Santa Caterina, Serv Rheumatol, Girona, Spain
Gonzalez, MJ:
Hosp Univ Quiron Dexeus, Serv Rheumatol, Barcelona, Spain
Codina, O:
Hosp Figueres, Serv Rheumatol, Figueres, Girona, Spain
Gelman, MS:
Fundacio Althaia Hosp Manresa, Serv Rheumatol, Barcelona, Spain
Juanola-Roura, X:
Hosp Univ Bellvitge, Serv Rheumatol, Barcelona, Spain
Olive, A:
Hosp Univ Germans Trias, Serv Rheumatol, Barcelona, Spain
Torrente-Segarra, V:
Hosp St Joan Despi Moises Broggi, Hosp Gen Hosp, Serv Rheumatol, CSI, Avda Jacint Verdaguer 90, Barcelona 08970, Catalonia, Spain
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