Neuropsychiatric symptoms are very common in premanifest and early stage Huntington's Disease
Por:
Martinez-Horta, S, Perez-Perez, J, van Duijn, E, Fernandez-Bobadilla, R, Carceller, M, Pagonabarraga, J, Pascual-Sedano, B, Campolongo, A, Ruiz-Idiago, J, Sampedro, F, Landwehrmeyer, GB, Kulisevsky, J
Publicada:
1 abr 2016
Resumen:
Background: Neuropsychiatric symptoms are common features of Huntington's disease (HD). Whereas most studies have focused on cognitive and neuroimaging markers of disease progression, little is known about the prevalence of neuropsychiatric symptoms in premanifest mutation carriers far-from and close to disease onset.
Methods: We obtained neurological, cognitive and behavioral data from 230 participants classified as premanifest far-from (preHD-A) and close-to (preHD-B) motor-based disease onset, early-symptomatic (early-HD), and healthy controls. Frequency and severity of neuropsychiatric symptoms were assessed with the short Problem Behaviors Assessment for HD (PBA-s). The odds-ratio (OR) to present symptoms in the clinical range was calculated using the control group as reference. Logistic regression analysis was used to explore relationships between neuropsychiatric symptoms and medication use.
Results: Prevalence of depression was similar in all groups. Apathy was already present in 32% of preHDA increasing to 62% of early-HD patients. The probability of presenting apathetic symptoms was 15-88 times higher in preHD-A and preHD-B respectively than in healthy controls. Irritability and executive dysfunction were present in both preHD-B and early-HD.
Conclusion: Neuropsychiatric symptoms are highly prevalent in HD, already in the premanifest stage, with increasing prevalence of irritability, apathy and executive dysfunction closer to onset. Compared to controls, HD mutation carriers have the highest probability to develop apathy, with an increasing prevalence along disease stages. Our findings confirm the high prevalence of neuropsychiatric symptoms in HD, already many years before the onset of motor symptoms, with apathy as an early manifestation and core neuropsychiatric feature of the disease. (C) 2016 Elsevier Ltd. All rights reserved.
Filiaciones:
Martinez-Horta, S:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Neurol, Movement Disorders Unit, E-08193 Barcelona, Spain
St Pau Inst Biomed Res IIb St Pau, Barcelona, Spain
CIBERNED, Madrid, Spain
UOC, Barcelona, Spain
Perez-Perez, J:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Neurol, Movement Disorders Unit, E-08193 Barcelona, Spain
St Pau Inst Biomed Res IIb St Pau, Barcelona, Spain
CIBERNED, Madrid, Spain
van Duijn, E:
Leiden Univ, Med Ctr, Dept Psychiat, Delft, Netherlands
Ctr Mental Hlth Care Delfland, Delft, Netherlands
Fernandez-Bobadilla, R:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Neurol, Movement Disorders Unit, E-08193 Barcelona, Spain
St Pau Inst Biomed Res IIb St Pau, Barcelona, Spain
CIBERNED, Madrid, Spain
UOC, Barcelona, Spain
Carceller, M:
St Pau Inst Biomed Res IIb St Pau, Barcelona, Spain
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Psychiat, E-08193 Barcelona, Spain
Pagonabarraga, J:
St Pau Inst Biomed Res IIb St Pau, Barcelona, Spain
CIBERNED, Madrid, Spain
Pascual-Sedano, B:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Neurol, Movement Disorders Unit, E-08193 Barcelona, Spain
St Pau Inst Biomed Res IIb St Pau, Barcelona, Spain
CIBERNED, Madrid, Spain
Campolongo, A:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Neurol, Movement Disorders Unit, E-08193 Barcelona, Spain
St Pau Inst Biomed Res IIb St Pau, Barcelona, Spain
CIBERNED, Madrid, Spain
Ruiz-Idiago, J:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Neurol, Movement Disorders Unit, E-08193 Barcelona, Spain
Hosp Mare de Deu de la Merce, Barcelona, Spain
Sampedro, F:
Autonomous Univ Barcelona, Fac Med, E-08193 Barcelona, Spain
Landwehrmeyer, GB:
Univ Ulm, Dept Neurol, D-89069 Ulm, Germany
Kulisevsky, J:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Neurol, Movement Disorders Unit, E-08193 Barcelona, Spain
St Pau Inst Biomed Res IIb St Pau, Barcelona, Spain
CIBERNED, Madrid, Spain
UOC, Barcelona, Spain
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