The Molecular Registry of Pituitary Adenomas (REMAH): A bet of Spanish Endocrinology for the future of individualized medicine and translational research
Por:
Luque, RM, Ibanez-Costa, A, Sanchez-Tejada, L, Rivero-Cortes, E, Robledo, M, Madrazo-Atutxa, A, Mora, M, Alvarez, CV, Lucas-Morante, T, Alvarez-Escola, C, Fajardo, C, Castano, L, Gaztambide, S, Venegas-Moreno, E, Soto-Moreno, A, Galvez, MA, Salvador, J, Valassi, E, Webb, SM, Pico, A, Puig-Domingo, M, Gilabert, M, Bernabeu, I, Marazuela, M, Leal-Cerro, A, Castano, JP
Publicada:
1 jun 2016
Resumen:
Pituitary adenomas are uncommon, difficult to diagnose tumors whose heterogeneity and low incidence complicate large-scale studies. The Molecular Registry of Pituitary Adenomas (REMAH) was promoted by the Andalusian Society of Endocrinology and Nutrition (SAEN) in 2008 as a cooperative clinical-basic multicenter strategy aimed at improving diagnosis and treatment of pituitary adenomas by combining clinical, pathological, and molecular information. In 2010, the Spanish Society of Endocrinology and Nutrition (SEEN) extended this project to national level and established 6 nodes with common protocols and methods for sample and clinical data collection, molecular analysis, and data recording in a common registry (www.remahnacional.com). The registry combines clinical data with molecular phenotyping of the resected pituitary adenoma using quantitative real-time PCR of expression of 26 genes: Pituitary hormones (GH-PRL-LH-FSH-PRL-ACTH-CGA), receptors (somatostatin, dopamine, GHRH, GnRH, CRH, arginine-vasopressin, ghrelin), other markers (Ki67, PTTG1), and control genes. Until 2015, molecular information has been collected from 704 adenomas, out of 1179 patients registered. This strategy allows for comparative and relational analysis between the molecular profile of the different types of adenoma and the clinical phenotype of patients, which may provide a better understanding of the condition and potentially help in treatment selection. The REMAH is therefore a unique multicenter, interdisciplinary network founded on a shared database that provides a far-reaching translational approach for management of pituitary adenomas, and paves the way for the conduct of combined clinical-basic innovative studies on large patient samples. (C) 2016 SEEN. Published by Elsevier Espana, S.L.U. All rights reserved.
Filiaciones:
Luque, RM:
Univ Cordoba, Inst Maimonides Invest Biomed Cordoba IMIBIC, Cordoba, Spain
Univ Cordoba, Dept Biol Celular Fisiol & Inmunol, Cordoba, Spain
Hosp Univ Reina Sofia, Cordoba, Spain
Campus Excelencia Internacl Agroalimentario ceiA3, Cordoba, Spain
CIBER Fisiopatol Obesidad & Nutr, Cordoba, Spain
Ibanez-Costa, A:
Univ Cordoba, Inst Maimonides Invest Biomed Cordoba IMIBIC, Cordoba, Spain
Univ Cordoba, Dept Biol Celular Fisiol & Inmunol, Cordoba, Spain
Hosp Univ Reina Sofia, Cordoba, Spain
Campus Excelencia Internacl Agroalimentario ceiA3, Cordoba, Spain
CIBER Fisiopatol Obesidad & Nutr, Cordoba, Spain
Sanchez-Tejada, L:
Hosp Gen Univ Alicante, Dept Endocrinol, Alicante, Spain
Rivero-Cortes, E:
Univ Cordoba, Inst Maimonides Invest Biomed Cordoba IMIBIC, Cordoba, Spain
Univ Cordoba, Dept Biol Celular Fisiol & Inmunol, Cordoba, Spain
Hosp Univ Reina Sofia, Cordoba, Spain
Campus Excelencia Internacl Agroalimentario ceiA3, Cordoba, Spain
CIBER Fisiopatol Obesidad & Nutr, Cordoba, Spain
Robledo, M:
CNIO, Grp Canc Endocrino Hereditario, Madrid, Spain
Madrazo-Atutxa, A:
Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Unidad Gest Clin Endocrinol & Nutr,Inst Biomed Se, Seville, Spain
Mora, M:
Hosp Clin & Univ Barcelona, Unidad Endocrinol, Barcelona, Spain
Alvarez, CV:
Univ Santiago de Compostela, Ctr Singular Invest Med Mol & Enfermedades Cron C, Grp Neoplasia & Diferenciac Endocrina, Santiago De Compostela, Spain
Univ Santiago de Compostela, Inst Invest Sanitarias, Santiago De Compostela, Spain
Univ Santiago de Compostela, Fac Med, Santiago De Compostela, Spain
Lucas-Morante, T:
Hosp Univ Puerta Hierro, Serv Endocrinol & Nutr, Madrid, Spain
Alvarez-Escola, C:
Univ Autonoma Madrid, Hosp Univ La Paz, Serv Endocrinol & Nutr, Madrid, Spain
Fajardo, C:
Hosp Univ la Ribera, Serv Endocrinol, Alzira, Spain
Castano, L:
Hosp Univ Cruces, Grp Invest Endocrinol & Diabet, Baracaldo, Spain
Gaztambide, S:
Hosp Univ Cruces, Dept Endocrinol & Nutr, Baracaldo, Spain
Venegas-Moreno, E:
Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Unidad Gest Clin Endocrinol & Nutr,Inst Biomed Se, Seville, Spain
Soto-Moreno, A:
Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Unidad Gest Clin Endocrinol & Nutr,Inst Biomed Se, Seville, Spain
Galvez, MA:
Hosp Univ Reina Sofia, Serv Endocrinol & Nutr, Cordoba, Spain
Inst Maimonides Invest Biomed Cordoba, Cordoba, Spain
Salvador, J:
Univ Navarra, Univ Navarra Clin, Dept Endocrinol & Nutr, E-31080 Pamplona, Spain
Inst Invest Sanitaria Navarra IdiSNA, Pamplona, Spain
Valassi, E:
Inst Salud Carlos III, CIBER ER, Inst Invest Biomed St Pau, Unidad 747, Barcelona, Spain
Webb, SM:
Inst Salud Carlos III, CIBER ER, Inst Invest Biomed St Pau, Unidad 747, Barcelona, Spain
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Inst Invest Biomed St Pau, Serv Endocrinol,Dept Med, E-08193 Barcelona, Spain
Pico, A:
Hosp Gen Univ Alicante, Dept Endocrinol, Alicante, Spain
Puig-Domingo, M:
Hosp Badalona Germans Trias & Pujol, Dept Endocrinol & Nutr, Badalona, Spain
Ctr Invest Biomed Enfermedades Raras CIBER ER, Badalona, Spain
Gilabert, M:
Novartis Farmaceut, Dept Med, Barcelona, Spain
Bernabeu, I:
Complejo Hosp Univ Santiago, Serv Endocrinol & Nutr, Santiago De Compostela, Spain
Marazuela, M:
Hosp Univ La Princesa, Serv Endocrinol & Nutr, Madrid, Spain
Leal-Cerro, A:
Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Lab Endocrinol,IBiS, Seville, Spain
Castano, JP:
Univ Cordoba, Inst Maimonides Invest Biomed Cordoba IMIBIC, Cordoba, Spain
Univ Cordoba, Dept Biol Celular Fisiol & Inmunol, Cordoba, Spain
Hosp Univ Reina Sofia, Cordoba, Spain
Campus Excelencia Internacl Agroalimentario ceiA3, Cordoba, Spain
CIBER Fisiopatol Obesidad & Nutr, Cordoba, Spain
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