Second-Generation Drug-Eluting Balloon for Ostial Side Branch Lesions (001-Bifurcations): Mid-Term Clinical and Angiographic Results
Por:
Vaquerizo, B, Fernandez-Nofreiras, E, Oategui, I, De Lezo, JS, Rumoroso, JR, Martin, P, Routledge, H, Tizon-Marcos, H
Publicada:
1 jun 2016
Resumen:
Background: In the drug-eluting stent era, the best strategy to treat Medina 001 lesion remains unestablished. This is the first prospective registry assessing the efficacy and safety of the second-generation drug-coated balloon in patients with side-branch ostial lesion.
Methods: Forty-nine patients with de novo Medina 001 lesion and associated myocardial ischemia were treated with second-generation drug-coated balloon-Dior balloon catheter (Eurocor GmbH, Bonn Germany), and prospectively included in this study. After mandatory pre-dilatation, a paclitaxel-eluting balloon was inflated for a minimum of 45 seconds. Left main bifurcation, severely calcified lesions and cardiogenic shock, were the only exclusion criteria.
Results: The inclusion period was 2.7 years. Mean age was 62 +/- 12 years old, 41% diabetic, 65% presented with acute coronary syndrome. The most common vessel treated was the first diagonal (50%). Pre-dilatation with a cutting balloon was used in 59%. Angiographic success was 86% (in 14% a bare metal stent was implanted because of acute recoil [n = 5] or coronary dissection more than type B [n = 2]). At a mean of 12.2 +/- 2.2 months, major cardiac adverse events rate was 14.3% (1 myocardial infarction, 0 cardiac deaths, 7 target lesion revascularization). There was no thrombosis or occlusion. At a mean of 7.2 +/- 1.1 months, binary restenosis was 22.5% (n = 7) with a late loss of 0.32 +/- 0.73 mm.
Conclusion: Medina 001 lesion is an infrequent type of coronary lesion. Drug-coated balloon-Dior is a safe and technically easy therapeutic option, associated with acceptable mid-term clinical outcomes.
Filiaciones:
Vaquerizo, B:
Hosp del Mar, Intervent Cardiol Unit, Barcelona, Spain
Hosp Santa Creu & Sant Pau, Intervent Cardiol Unit, Barcelona, Spain
Fernandez-Nofreiras, E:
Hosp Trias & Pujol, Intervent Cardiol Unit, Barcelona, Spain
Oategui, I:
Hosp Valle De Hebron, Intervent Cardiol Unit, Barcelona, Spain
De Lezo, JS:
Hosp Reina Sofia, Intervent Cardiol Unit, Cordoba, Spain
Rumoroso, JR:
Hosp Galdakao, Intervent Cardiol Unit, Galdakao, Spain
Martin, P:
Hosp Dr Negrin, Intervent Cardiol Unit, Gran Canaria, Spain
Routledge, H:
Worcestershire Royal Hosp, Dept Cardiol, Worcester, England
Tizon-Marcos, H:
Hosp del Mar, Intervent Cardiol Unit, Barcelona, Spain
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