Correlation of the patient's reported outcome Inflammatory-RODS with an objective metric in immune-mediated neuropathies
Por:
Draak, THP, Gorson, KC, Vanhoutte, EK, van Nes, SI, van Doorn, PA, Cornblath, DR, van den Berg, LH, Faber, CG, Merkies, ISJ, Querol, L., de Visser, Marianne
Publicada:
1 jul 2016
Resumen:
Background and purposeThere is increasing interest in using patient-reported outcome measures (PROMs) in clinical studies to capture individual changes over time. However, PROMs have also been criticized because they are entirely subjective. Our objective was to examine the relationship between a subjective PROM and an objective outcome tool in patients with Guillain-Barre syndrome (GBS), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and gammopathy-related polyneuropathy (MGUSP).
MethodsThe Inflammatory Rasch-built Overall Disability Scale (I-RODS (c), a multi-item scale that examines functionality) was completed by 137 patients with newly diagnosed (or relapsing) GBS (55), CIDP (59) and MGUSP (23) who were serially examined (GBS/CIDP, T0/T1/T3/T6/T12 months; MGUSP, T0/T3/T12). Possible association between the I-RODS findings and the vigorimeter scores, an objective linear instrument to assess grip strength, was examined.
ResultsA significant correlating trend was found between the I-RODS and grip strength scores for the overall group and in each illness, independently.
ConclusionThe objectivity of patients' subjective report on their functional state based on a strong correlation between the I-RODS and grip strength in patients with GBS, CIDP and MGUSP has been demonstrated. These findings provide further support to use the I-RODS and grip strength in future clinical studies in these conditions.
Filiaciones:
Draak, THP:
Univ Med Ctr Maastricht, Dept Neurol, POB 5800, NL-6202 AZ Maastricht, Netherlands
Gorson, KC:
Tufts Univ, Sch Med, St Elizabeths Med Ctr, Dept Neurol, Boston, MA 02111 USA
Vanhoutte, EK:
Maastricht Univ, Med Ctr, Dept Clin Genet, NL-6200 MD Maastricht, Netherlands
van Nes, SI:
Havenziekenhuis, Dept Neurol, Rotterdam, Netherlands
van Doorn, PA:
Erasmus MC, Dept Neurol, Rotterdam, Netherlands
Cornblath, DR:
Johns Hopkins Sch Med, Dept Neurol, Baltimore, MD USA
van den Berg, LH:
Univ Med Ctr Utrecht, Dept Neurol, Rudolf Magnus Inst Neurosci, Utrecht, Netherlands
Faber, CG:
Univ Med Ctr Maastricht, Dept Neurol, POB 5800, NL-6202 AZ Maastricht, Netherlands
Merkies, ISJ:
Univ Med Ctr Maastricht, Dept Neurol, POB 5800, NL-6202 AZ Maastricht, Netherlands
Spaarne Hosp, Dept Neurol, Hoofddorp, Netherlands
Querol, L.:
Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
de Visser, Marianne :
Amsterdam UMC - University of Amsterdam, Amsterdam, Netherlands
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