Oropharyngeal and laryngeal sensory innervation in the pathophysiology of swallowing disorders and sensory stimulation treatments
Por:
Alvarez-Berdugo, D, Rofes, L, Casamitjana, JF, Padron, A, Quer, M, Clave, P
Publicada:
1 ene 2016
Resumen:
Oropharyngeal dysphagia (OD) affects older and neurological patients, causing malnutrition and dehydration and increasing the risk for aspiration pneumonia. There is evidence that sensory deficits in those populations are closely related to swallowing disorders, and several research groups are developing new therapies based on sensory stimulation of this area. More information on the sensory innervation participating in the swallow response is needed to better understand the pathophysiology of OD and to develop new treatments. This review focuses on the sensory innervation of the human oropharynx and larynx in healthy people compared with patients with swallowing disorders in order to unravel the abnormalities that may lead to the loss of sensitivity in patients with OD. We also hypothesize the pathway through which active sensory-enhancement treatments may elicit their therapeutic effect on patients with swallowing dysfunctions. As far as we know, this is the first time a review covers the anatomy, histology, ultrastructure, and molecular biology of the sensory innervation of the swallowing function.
Filiaciones:
Alvarez-Berdugo, D:
Hosp Mataro, Consorci Sanitari Maresme Mataro, Gastrointestinal Motil Lab, Mataro, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Barcelona, Spain
Rofes, L:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Barcelona, Spain
Casamitjana, JF:
Hosp Mataro, Consorci Sanitari Maresme, ENT Dept, Mataro, Spain
Padron, A:
Hosp Mataro, Consorci Sanitari Maresme, Dept Pathol, Mataro, Spain
Quer, M:
Hosp Santa Creu & Sant Pau, ENT & Cervicofacial Pathol Dept, Barcelona, Spain
Clave, P:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Barcelona, Spain
Fundacio Inst Invest Germans Trias & Pujol, Badalona, Spain
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