Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

Por: van Rheenen, W, Shatunov, A, Dekker, AM, McLaughlin, RL, Diekstra, FP, Pulit, SL, van der Spek, RAA, Vosa, U, de Jong, S, Robinson, MR, Yang, J, Fogh, I, van Doormaal, PTC, Tazelaar, GHP, Koppers, M, Blokhuis, AM, Sproviero, W, Jones, AR, Kenna, KP, van Eijk, KR, Harschnitz, O, Schellevis, RD, Brands, WJ, Medic, J, Menelaou, A, Vajda, A, Ticozzi, N, Lin, K, Rogelj, B, Vrabec, K, Ravnik-Glavac, M, Koritnik, B, Zidar, J, Leonardis, L, Groselj, LD, Millecamps, S, Salachas, F, Meininger, V, de Carvalho, M, Pinto, S, Mora, JS, Rojas-Garcia, R, Polak, M, Chandran, S, Colville, S, Swingler, R, Morrison, KE, Shaw, PJ, Hardy, J, Orrell, RW, Pittman, A, Sidle, K, Fratta, P, Malaspina, A, Topp, S, Petri, S, Abdulla, S, Drepper, C, Sendtner, M, Meyer, T, Ophoff, RA, Staats, KA, Wiedau-Pazos, M, Lomen-Hoerth, C, Van Deerlin, VM, Trojanowski, JQ, Elman, L, McCluskey, L, Basak, AN, Tunca, C, Hanizeiy, H, Parman, Y, Meitinger, T, Lichtner, P, Radivojkov-Blagojevic, M, Andres, CR, Maurel, C, Bensimon, G, Landwehrmeyer, B, Brice, A, Payan, CAM, Saker-Delye, S, Durr, A, Wood, NW, Tittmann, L, Lieb, W, Franke, A, Rietschel, M, Cichon, S, Nothen, MM, Amouyel, P, Tzourio, C, Dartigues, JF, Uitterlinden, AG, Rivadeneira, F, Estrada, K, Hofman, A, Curtis, C, Blauw, HM, van der Kooi, AJ, de Visser, M, Goris, A, Weber, M, Shaw, CE, Smith, BN, Pansarasa, O, Cereda, C, Del Bo, R, Comi, GP, D'Alfonso, S, Bertolin, C, Soraru, G, Mazzini, L, Pensato, V, Gellera, C, Tiloca, C, Ratti, A, Calvo, A, Moglia, C, Brunetti, M, Arcuti, S, Capozzo, R, Zecca, C, Lunetta, C, Penco, S, Riva, N, Padovani, A, Filosto, M, Muller, B, Stuit, RJ, Blair, I, Zhang, K, McCann, EP, Fifita, JA, Nicholson, GA, Rowe, DB, Pamphlett, R, Kiernan, MC, Grosskreutz, J, Witte, OW, Ringer, T, Prell, T, Stubendorff, B, Kurth, I, Hubner, CA, Leigh, PN, Casale, F, Chio, A, Beghi, E, Pupillo, E, Tortelli, R, Logroscino, G, Powell, J, Ludolph, AC, Weishaupt, JH, Robberecht, W, Van Damme, P, Franke, L, Pers, TH, Brown, RH, Glass, JD, Landers, JE, Hardiman, O, Andersen, PM, Corcia, P, Vourc'h, P, Silani, V, Wray, NR, Visscher, PM, de Bakker, PIW, van Es, MA, Pasterkamp, RJ, Lewis, CM, Breen, G, Al-Chalabi, A, van den Berg, LH, Veldink, JH

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Publicada: 1 sep 2016

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Filiaciones:
van Rheenen, W:
 Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol, Utrecht, Netherlands

Shatunov, A:
 Kings Coll London, Maurice Wohl Clin Neurosci Inst, Dept Basic & Clin Neurosci, London, England

Dekker, AM:
 Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol, Utrecht, Netherlands

McLaughlin, RL:
 Trinity Coll Dublin, Smurfit Inst Genet, Populat Genet Lab, Dublin, Ireland

Diekstra, FP:
 Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol, Utrecht, Netherlands

Pulit, SL:
 Univ Med Ctr Utrecht, Ctr Mol Med, Dept Med Genet, Utrecht, Netherlands

van der Spek, RAA:
 Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol, Utrecht, Netherlands

Vosa, U:
 Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands

de Jong, S:
 Kings Coll London, MRC Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England

 Kings Coll London, Maudsley Hosp, NIFIR Biomed Res Ctr Mental Hlth, London, England

 Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England

Robinson, MR:
 Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia

Yang, J:
 Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia

Fogh, I:
 Kings Coll London, Maurice Wohl Clin Neurosci Inst, Dept Basic & Clin Neurosci, London, England

 IRCCS Ist Auxol Italiano, Dept Neurol & Lab Neurosci, Milan, Italy

van Doormaal, PTC:
 Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol, Utrecht, Netherlands

Tazelaar, GHP:
 Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol, Utrecht, Netherlands

Koppers, M:
 Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol, Utrecht, Netherlands

 Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Translat Neurosci, Utrecht, Netherlands

Blokhuis, AM:
 Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol, Utrecht, Netherlands

 Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Translat Neurosci, Utrecht, Netherlands

Sproviero, W:
 Kings Coll London, Maurice Wohl Clin Neurosci Inst, Dept Basic & Clin Neurosci, London, England

Jones, AR:
 Kings Coll London, Maurice Wohl Clin Neurosci Inst, Dept Basic & Clin Neurosci, London, England

Kenna, KP:
 Univ Massachusetts, Sch Med, Dept Neurol, Worcester, MA USA

van Eijk, KR:
 Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol, Utrecht, Netherlands

Harschnitz, O:
 Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol, Utrecht, Netherlands

 Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Translat Neurosci, Utrecht, Netherlands

Schellevis, RD:
 Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol, Utrecht, Netherlands

Brands, WJ:
 Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol, Utrecht, Netherlands

Medic, J:
 Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol, Utrecht, Netherlands

Menelaou, A:
 Univ Med Ctr Utrecht, Ctr Mol Med, Dept Med Genet, Utrecht, Netherlands

Vajda, A:
 Trinity Coll Dublin, Trinity BioMed Sci Inst, Acad Unit Neurol, Dublin, Ireland

 Beaumont Hosp, Dept Neurol, Dublin, Ireland

Ticozzi, N:
 IRCCS Ist Auxol Italiano, Dept Neurol & Lab Neurosci, Milan, Italy

 Univ Milan, Dino Ferrari Ctr, Dept Pathophysiol & Tranplantat, Milan, Italy

Lin, K:
 Kings Coll London, Maurice Wohl Clin Neurosci Inst, Dept Basic & Clin Neurosci, London, England

Rogelj, B:
 Jozef Stefan Inst, Dept Biotechnol, Ljubljana, Slovenia

 BioMed Res Inst BRIS, Ljubljana, Slovenia

Vrabec, K:
 Univ Ljubljana, Fac Med, Inst Pathol, Dept Mol Genet, Ljubljana, Slovenia

Ravnik-Glavac, M:
 Univ Ljubljana, Fac Med, Inst Pathol, Dept Mol Genet, Ljubljana, Slovenia

 Univ Ljubljana, Fac Med, Inst Biochem, Ljubljana, Slovenia

Koritnik, B:
 Univ Med Ctr Ljubljana, Ljubljana ALS Ctr, Inst Clin Neurophysiol, Ljubljana, Slovenia

Zidar, J:
 Univ Med Ctr Ljubljana, Ljubljana ALS Ctr, Inst Clin Neurophysiol, Ljubljana, Slovenia

Leonardis, L:
 Univ Med Ctr Ljubljana, Ljubljana ALS Ctr, Inst Clin Neurophysiol, Ljubljana, Slovenia

Groselj, LD:
 Univ Med Ctr Ljubljana, Ljubljana ALS Ctr, Inst Clin Neurophysiol, Ljubljana, Slovenia

Millecamps, S:
 Univ Paris 06, Sorbonne Univ, Inst Cerveau & Moelle Epiniere, CNRS UMR 7225,INSERM U1127,UMRS 1127, Paris, France

Salachas, F:
 Univ Paris 06, Sorbonne Univ, Inst Cerveau & Moelle Epiniere, CNRS UMR 7225,INSERM U1127,UMRS 1127, Paris, France

 Hop La Pitie Salpetriere, Ctr Reference Malad Races SLA Ile France, Dept Neurol, Paris, France

 GRC UPMC SEA & Malad Motoneurone, Paris, France

Meininger, V:
 Hop Peupliers, Ramsay Gen Sante, Paris, France

 Reseau SEA Ile France, Paris, France

de Carvalho, M:
 Univ Lisbon, Fac Med, Inst Mol Med, Inst Physiol, Lisbon, Portugal

 Hosp Santa Maria CHLN, Dept Neurosci, Lisbon, Portugal

Pinto, S:
 Univ Lisbon, Fac Med, Inst Mol Med, Inst Physiol, Lisbon, Portugal

 Hosp Santa Maria CHLN, Dept Neurosci, Lisbon, Portugal

Mora, JS:
 Hosp San Rafael, Dept Neurol, Madrid, Spain

Rojas-Garcia, R:
 Autonomous Univ Barcelona, Hosp Santa Creu & St Pau Barcelona, Dept Neurol, Barcelona, Spain

 Ctr Invest Red Enfermedades Raras CIBFRFR, Madrid, Spain

Polak, M:
 Emory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USA

 Emory Univ, Sch Med, Emory ALS Ctr, Atlanta, GA USA

Chandran, S:
 Euan MacDonald Ctr Motor Neuron Dis Res, Edinburgh, Midlothian, Scotland

 Univ Edinburgh, Ctr Neuroregenerat, Edinburgh, Midlothian, Scotland

 Univ Edinburgh, Ctr Regenerat Med, MRC, Edinburgh, Midlothian, Scotland

Colville, S:
 Euan MacDonald Ctr Motor Neuron Dis Res, Edinburgh, Midlothian, Scotland

Swingler, R:
 Euan MacDonald Ctr Motor Neuron Dis Res, Edinburgh, Midlothian, Scotland

Morrison, KE:
 Univ Southampton, Fac Med, Southampton, Hants, England

Shaw, PJ:
 Univ Sheffield, Sheffield Inst Translat Neurosci SITraN, Sheffield, S Yorkshire, England

Hardy, J:
 UCL, Inst Neurol, Dept Mol Neurosci, London, England

Orrell, RW:
 UCL, Inst Neurol, Dept Clin Neurosci, London, England

Pittman, A:
 UCL, Inst Neurol, Dept Mol Neurosci, London, England

 UCL, Inst Neurol, Reta Lila Weston Inst, London, England

Sidle, K:
 UCL, Inst Neurol, Dept Clin Neurosci, London, England

Fratta, P:
 UCL, Inst Neurol, Sobell Dept Motor Neurosci & Movement Disorders, London, England

Malaspina, A:
 Queen Mary Univ London, Ctr Neurosci & Trauma, Blizard Inst, London, England

 North East London & Essex Reg Motor Neuron Dis Ca, London, England

Topp, S:
 Kings Coll London, Maurice Wohl Clin Neurosci Inst, Dept Basic & Clin Neurosci, London, England

Petri, S:
 Hannover Med Sch, Dept Neurol, Hannover, Germany

Abdulla, S:
 Univ Magdeburg, Dept Neurol, Magdeburg, Germany

Drepper, C:
 Univ Hosp Wurzburg, Inst Clin Neurobiol, Wurzburg, Germany

Sendtner, M:
 Univ Hosp Wurzburg, Inst Clin Neurobiol, Wurzburg, Germany

Meyer, T:
 Humboldt Univ, Charite Univ Hosp, Dept Neurol, Berlin, Germany

Ophoff, RA:
 Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Dept Psychiat, Utrecht, Netherlands

 Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA

 Univ Calif Los Angeles, Ctr Neurobehav Genet, Sernel Inst Neurosci & Human Behav, Los Angeles, CA USA

Staats, KA:
 Univ Calif Los Angeles, Ctr Neurobehav Genet, Sernel Inst Neurosci & Human Behav, Los Angeles, CA USA

Wiedau-Pazos, M:
 Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA

Lomen-Hoerth, C:
 Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA

Van Deerlin, VM:
 Univ Penn, Perelman Sch Med, Ctr Neurodegenerat Dis Res, Philadelphia, PA 19104 USA

Trojanowski, JQ:
 Univ Penn, Perelman Sch Med, Ctr Neurodegenerat Dis Res, Philadelphia, PA 19104 USA

Elman, L:
 Univ Penn, Perelman Sch Med, Dept Neurol, Philadelphia, PA USA

McCluskey, L:
 Univ Penn, Perelman Sch Med, Dept Neurol, Philadelphia, PA USA

Basak, AN:
 Univ Edinburgh, Ctr Regenerat Med, MRC, Edinburgh, Midlothian, Scotland

 Bogazici Univ, Neurodegenerat Res Lab, Istanbul, Turkey

 Univ Kiel, Inst Clin Mol Biol, Kiel, Germany

Tunca, C:
 Bogazici Univ, Neurodegenerat Res Lab, Istanbul, Turkey

Hanizeiy, H:
 Bogazici Univ, Neurodegenerat Res Lab, Istanbul, Turkey

Parman, Y:
 Istanbul Univ, Istanbul Med Sch, Dept Neurol, Istanbul, Turkey

Meitinger, T:
 Helmholtz Zentrum Munchen, Inst Human Genet, Neuherberg, Germany

Lichtner, P:
 Helmholtz Zentrum Munchen, Inst Human Genet, Neuherberg, Germany

Radivojkov-Blagojevic, M:
 Helmholtz Zentrum Munchen, Inst Human Genet, Neuherberg, Germany

Andres, CR:
 Univ Tours, INSERM U930, Tours, France

Maurel, C:
 Univ Tours, INSERM U930, Tours, France

Bensimon, G:
 Hop La Pitie Salpetriere, AP HP, Dept Clin Pharmacol, Paris, France

 Univ Paris 06, Pharmacol, Paris, France

 CHU Nimes, BESPIM, Nimes, France

Landwehrmeyer, B:
 Univ Ulm, Dept Neurol, Ulm, Germany

Brice, A:
 Hop La Pitie Salpetriere, INSERM U1127, Paris, France

 Hop La Pitie Salpetriere, CNRS UMR 7225, Paris, France

 Univ Paris 06, Sorbonne Univ, Hop Pitie Salpetriere, UMRS 1127, Paris, France

 Hop La Pitie Salpetriere, Inst Cerveau & Moelle Epiniere, Paris, France

 Hop La Pitie Salpetriere, AP HP, Dept Genet, Paris, France

Payan, CAM:
 Hop La Pitie Salpetriere, AP HP, Dept Clin Pharmacol, Paris, France

 CHU Nimes, BESPIM, Nimes, France

Saker-Delye, S:
 Genethon, CNRS UMR 8587, Evry, France

Durr, A:
 Hop La Pitie Salpetriere, Inst Cerveau & Moelle Epiniere, Dept Med Genet, Paris, France

Wood, NW:
 Univ College London, Inst Neurol, Dept Neurogenet, London, England

Tittmann, L:
 Christian Albrechts Univ Kiel, PopGen Biobarik, Kiel, Germany

 Christian Albrechts Univ Kiel, Inst Epidemiol, Kiel, Germany

Lieb, W:
 Christian Albrechts Univ Kiel, PopGen Biobarik, Kiel, Germany

 Christian Albrechts Univ Kiel, Inst Epidemiol, Kiel, Germany

Franke, A:
 Univ Kiel, Inst Clin Mol Biol, Kiel, Germany

Rietschel, M:
 Heidelberg Univ, Fac Med Mannheim, Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat, Heidelberg, Germany

Cichon, S:
 Univ Bonn, Inst Human Genet, Bonn, Germany

 Life & Brain Ctr, Dept Genom, Bonn, Germany

 Univ Basel, Univ Basel Hosp, Div Med Genet, Basel, Switzerland

 Univ Basel, Dept Biomed, Basel, Switzerland

 Res Ctr Juelich, Inst Neurosci & Med INM 1, Julich, Germany

Nothen, MM:
 Univ Bonn, Inst Human Genet, Bonn, Germany

 Life & Brain Ctr, Dept Genom, Bonn, Germany

Amouyel, P:
 Univ Lille, CHU Lille, INSERM, Inst Pasteur Lille,RID AGE Risk Factor & Mol Dete, Lille, France

Tzourio, C:
 Univ Bordeaux, ISPED, INSERM U1219, Epidemiol Biostat, Bordeaux, France

 CHU Bordeaux, CIC 1401, Pole Sante Publ, Bordeaux, France

Dartigues, JF:
 Univ Bordeaux, ISPED, INSERM U1219, Epidemiol Biostat, Bordeaux, France

 CHU Bordeaux, CIC 1401, Pole Sante Publ, Bordeaux, France

Uitterlinden, AG:
 Erasmus MC, Dept Internal Med, Genet Lab, Rotterdam, Netherlands

 Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

Rivadeneira, F:
 Erasmus MC, Dept Internal Med, Genet Lab, Rotterdam, Netherlands

 Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

Estrada, K:
 Erasmus MC, Dept Internal Med, Genet Lab, Rotterdam, Netherlands

Hofman, A:
 Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

 Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

Curtis, C:
 Kings Coll London, MRC Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England

 Kings Coll London, Maudsley Hosp, NIFIR Biomed Res Ctr Mental Hlth, London, England

 Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England

Blauw, HM:
 Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol, Utrecht, Netherlands

van der Kooi, AJ:
 Univ Amsterdam, Acad Med Ctr, Dept Neurol, Amsterdam, Netherlands

de Visser, M:
 Univ Amsterdam, Acad Med Ctr, Dept Neurol, Amsterdam, Netherlands

Goris, A:
 Katholieke Univ Leuven, Univ Leuven, Leuven Res Inst Neurosci & Dis LIND, Dpet Neurosci Expt Neurol, Leuven, Belgium

Weber, M:
 Kantonsspital St Gallen, ALS Clin, Neuromuscular Dis Unit, St Gallen, Switzerland

Shaw, CE:
 Kings Coll London, Maurice Wohl Clin Neurosci Inst, Dept Basic & Clin Neurosci, London, England

Smith, BN:
 Kings Coll London, Maurice Wohl Clin Neurosci Inst, Dept Basic & Clin Neurosci, London, England

Pansarasa, O:
 IRCCS C Mondino Natl Inst Neurol Fdn, Lab Expt Neurobiol, Pavia, Italy

Cereda, C:
 IRCCS C Mondino Natl Inst Neurol Fdn, Lab Expt Neurobiol, Pavia, Italy

Del Bo, R:
 IRCCS Fdn Ca Granda Osped Maggiore Policlin, Neurol Unit, Milan, Italy

Comi, GP:
 IRCCS Fdn Ca Granda Osped Maggiore Policlin, Neurol Unit, Milan, Italy

D'Alfonso, S:
 Univ Piemonte Orientale, Interdisciplinary Res Ctr Autoimmune Dis, Dept Hlth Sci, Novara, Italy

Bertolin, C:
 Univ Padua, Dept Neurosci, Padua, Italy

Soraru, G:
 Univ Padua, Dept Neurosci, Padua, Italy

Mazzini, L:
 Univ Piemonte Orientals, Dept Neurol, Novara, Italy

Pensato, V:
 Fdn IRCCS Ist Neurol Carlo Besta, Unit Genet Neurodegenerat & Metab Dis, Milan, Italy

Gellera, C:
 Fdn IRCCS Ist Neurol Carlo Besta, Unit Genet Neurodegenerat & Metab Dis, Milan, Italy

Tiloca, C:
 IRCCS Ist Auxol Italiano, Dept Neurol & Lab Neurosci, Milan, Italy

Ratti, A:
 IRCCS Ist Auxol Italiano, Dept Neurol & Lab Neurosci, Milan, Italy

 Univ Milan, Dino Ferrari Ctr, Dept Pathophysiol & Tranplantat, Milan, Italy

Calvo, A:
 Univ Turin, ALS Ctr, Rita Levi Montalcini Dept Neurosci, Turin, Italy

 Azienda Osped Citta Salute & Sci, Turin, Italy

Moglia, C:
 Univ Turin, ALS Ctr, Rita Levi Montalcini Dept Neurosci, Turin, Italy

 Azienda Osped Citta Salute & Sci, Turin, Italy

Brunetti, M:
 Univ Turin, ALS Ctr, Rita Levi Montalcini Dept Neurosci, Turin, Italy

 Azienda Osped Citta Salute & Sci, Turin, Italy

Arcuti, S:
 Univ Bari A Moro, Dept Clin Res Neurol, Tricase, Italy

 Pia Fdn Card G Panico, Tricase, Italy

Capozzo, R:
 Univ Bari A Moro, Dept Clin Res Neurol, Tricase, Italy

 Pia Fdn Card G Panico, Tricase, Italy

Zecca, C:
 Univ Bari A Moro, Dept Clin Res Neurol, Tricase, Italy

 Pia Fdn Card G Panico, Tricase, Italy

Lunetta, C:
 Niguarda Ca Granda Hostipal, Serena Onlins Fdn, NEMO Clin Ctr, Milan, Italy

Penco, S:
 Osped Niguarda Ca Granda, Dept Lab Med, Med Genet Unit, Milan, Italy

Riva, N:
 Ist Sci San Raffaele, Inst Expt Neurol INSPE, Dept Neurol, Div Neurosci, Milan, Italy

Padovani, A:
 Univ Brescia, Dept Clin & Expt Sci, Neurol Unit, Brescia, Italy

Filosto, M:
 Univ Brescia, Dept Clin & Expt Sci, Neurol Unit, Brescia, Italy

Muller, B:
 Project MinE Fdn, Rotterdam, Netherlands

Stuit, RJ:
 Project MinE Fdn, Rotterdam, Netherlands

Blair, I:
 Macquarie Univ, Fac Med & Hlth Sci, Dept Biomed Sci, Sydney, NSW, Australia

Zhang, K:
 Macquarie Univ, Fac Med & Hlth Sci, Dept Biomed Sci, Sydney, NSW, Australia

McCann, EP:
 Macquarie Univ, Fac Med & Hlth Sci, Dept Biomed Sci, Sydney, NSW, Australia

Fifita, JA:
 Macquarie Univ, Fac Med & Hlth Sci, Dept Biomed Sci, Sydney, NSW, Australia

Nicholson, GA:
 Macquarie Univ, Fac Med & Hlth Sci, Dept Biomed Sci, Sydney, NSW, Australia

 Univ Sydney, ANZAC Res Inst, Sydney, NSW, Australia

Rowe, DB:
 Macquarie Univ, Fac Med & Hlth Sci, Dept Biomed Sci, Sydney, NSW, Australia

Pamphlett, R:
 Univ Sydney, Dept Pathol, Stacey MND Lab, Sydney, NSW, Australia

Kiernan, MC:
 Univ Sydney, Brain & Mind Ctr, Sydney, NSW, Australia

Grosskreutz, J:
 Jena Univ Hosp, Hans Berger Dept Neurol, Jena, Germany

Witte, OW:
 Jena Univ Hosp, Hans Berger Dept Neurol, Jena, Germany

Ringer, T:
 Jena Univ Hosp, Hans Berger Dept Neurol, Jena, Germany

Prell, T:
 Jena Univ Hosp, Hans Berger Dept Neurol, Jena, Germany

Stubendorff, B:
 Jena Univ Hosp, Hans Berger Dept Neurol, Jena, Germany

Kurth, I:
 Jena Univ Hosp, Inst Human Genet, Jena, Germany

Hubner, CA:
 Jena Univ Hosp, Inst Human Genet, Jena, Germany

Leigh, PN:
 Univ Sussex, Trafford Ctr Biomed Res, Brighton & Sussex Med Sch, Dept Neurol, Falmer, England

Casale, F:
 Univ Turin, ALS Ctr, Rita Levi Montalcini Dept Neurosci, Turin, Italy

Chio, A:
 Univ Turin, ALS Ctr, Rita Levi Montalcini Dept Neurosci, Turin, Italy

 Azienda Osped Citta Salute & Sci, Turin, Italy

Beghi, E:
 IRCCS Ist Ric Farmacol Mario Negri, Dept Neurosci, Lab Neurol Dis, Milan, Italy

Pupillo, E:
 IRCCS Ist Ric Farmacol Mario Negri, Dept Neurosci, Lab Neurol Dis, Milan, Italy

Tortelli, R:
 Univ Bari A Moro, Dept Clin Res Neurol, Tricase, Italy

 Pia Fdn Card G Panico, Tricase, Italy

Logroscino, G:
 Univ Bari Aldo Moro, Dept Basic Med Sci Neurosci & Sense Organs, Bari, Italy

 Univ Bari Aldo Moro, Pia Fdn Cardinale G Panico, Dept Clin Res Neurol, Unit Neurodegenerat Dis, Tricase, Italy

Powell, J:
 Kings Coll London, Maurice Wohl Clin Neurosci Inst, Dept Basic & Clin Neurosci, London, England

Ludolph, AC:
 Univ Ulm, Dept Neurol, Ulm, Germany

Weishaupt, JH:
 Univ Ulm, Dept Neurol, Ulm, Germany

Robberecht, W:
 Katholieke Univ Leuven, Univ Leuven, Leuven Res Inst Neurosci & Dis LIND, Dpet Neurosci Expt Neurol, Leuven, Belgium

 VIB, Vesalius Res Ctr, Neurobiol Lab, Leuven, Belgium

 Univ Hosp Leuven, Dept Neurol, Leuven, Belgium

Van Damme, P:
 Katholieke Univ Leuven, Univ Leuven, Leuven Res Inst Neurosci & Dis LIND, Dpet Neurosci Expt Neurol, Leuven, Belgium

 VIB, Vesalius Res Ctr, Neurobiol Lab, Leuven, Belgium

 Univ Hosp Leuven, Dept Neurol, Leuven, Belgium

Franke, L:
 Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands

Pers, TH:
 Boston Childrens Hosp, Div Endocrinol, Boston, MA USA

 Boston Childrens Hosp, Div Genet, Boston, MA USA

 Boston Childrens Hosp, Ctr Basic Translat Obes Res, Boston, MA USA

 Harvard Med Sch, Dept Genet, Boston, MA USA

 Broad Inst, Program Med & Populat Genet, Carnbridge, MA USA

Brown, RH:
 Univ Massachusetts, Sch Med, Dept Neurol, Worcester, MA USA

Glass, JD:
 Emory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USA

 Emory Univ, Sch Med, Emory ALS Ctr, Atlanta, GA USA

Landers, JE:
 Univ Massachusetts, Sch Med, Dept Neurol, Worcester, MA USA

Hardiman, O:
 Trinity Coll Dublin, Trinity BioMed Sci Inst, Acad Unit Neurol, Dublin, Ireland

 Beaumont Hosp, Dept Neurol, Dublin, Ireland

Andersen, PM:
 Univ Ulm, Dept Neurol, Ulm, Germany

 Umea Univ, Dept Pharmacol & Clin Neurosci, Umea, Sweden

Corcia, P:
 Univ Tours, INSERM U930, Tours, France

 CHRU Tours, Ctr SLA, Tours, France

 LITORALS, Federat Ctr SLA Tours & Limoges, Tours, France

Vourc'h, P:
 Univ Tours, INSERM U930, Tours, France

Silani, V:
 IRCCS Ist Auxol Italiano, Dept Neurol & Lab Neurosci, Milan, Italy

 Univ Milan, Dino Ferrari Ctr, Dept Pathophysiol & Tranplantat, Milan, Italy

Wray, NR:
 Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia

Visscher, PM:
 Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia

 Univ Queensland, Translat Res Inst, Diarnantina Inst, Brisbane, Qld, Australia

de Bakker, PIW:
 Univ Med Ctr Utrecht, Ctr Mol Med, Dept Med Genet, Utrecht, Netherlands

 Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Dept Epidemiol, Utrecht, Netherlands

van Es, MA:
 Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol, Utrecht, Netherlands

Pasterkamp, RJ:
 Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Translat Neurosci, Utrecht, Netherlands

Lewis, CM:
 Kings Coll London, MRC Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England

 Kings Coll London, Dept Med & Mol Genet, London, England

Breen, G:
 Kings Coll London, MRC Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England

 Kings Coll London, Maudsley Hosp, NIFIR Biomed Res Ctr Mental Hlth, London, England

 Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England

Al-Chalabi, A:
 Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol, Utrecht, Netherlands

van den Berg, LH:
 Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol, Utrecht, Netherlands

Veldink, JH:
 Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol, Utrecht, Netherlands