Genetic determinants of cardiometabolic risk factors in rural families in Brazil
Por:
Pena, GG, Martinez-Perez, A, Dutra, MS, Gazzinelli, A, Correa-Oliveira, R, Soria, JM, Velasquez-Melendez, G
Publicada:
1 sep 2016
Resumen:
ObjectivesThe purpose of this study was to estimate the heritability of genetic and environmental correlations between cardiometabolic risk factors in extended pedigrees.
MethodsThe Jequitinhonha Community Family Study Cohort (JCFSC) consists of individuals aged 18 years living in rural villages. Family pedigrees were constructed of the cohort. The following data were collected: demographic and socioeconomic status, lifestyle variables, anthropometrics, and lipid traits.
ResultsThe JCFSC consists of 931 individuals distributed into 69 pedigrees with 4,907 members in total. The heritabilities were 0.47 for total cholesterol (TC), 0.44 for triglycerides (TG) and 0.42 for high-density lipoprotein cholesterol (HDLc), 0.49 for metabolic syndrome, approximately 0.60 for anthropometric traits and 0.30 for blood pressure/hypertension. Significant genetic correlations ((g)) were found mainly between TG and TC ((g)=0.58) and hypertension and TG ((g)=0.52). Systolic blood pressure (SBP) was correlated with TG ((g)=0.39) and HDLc ((g)=-0.30). Diastolic blood pressures correlated with TG ((g)=0.56) and TC ((g)=0.30). Genetic correlations were also found between anthropometric traits, including: body mass index (BMI) and TG ((g)=0.34), waist circumference (WC) and TG ((g)=0.42), and WC and HDLc ((g)=-0.33). Household effects were found for HDLc (c(2)= 0.19), SBP (c(2)=0.14) and Hypertension (c(2)= 0.14).
ConclusionsTo some phenotypes, including lipids, hypertension, blood pressure, and anthropometric traits, genetic contribution is important in the determination of cardiometabolic risk factors. This study provides a foundation for future studies. These will mainly focus on rare variants that could describe the genetic mechanisms influencing cardiometabolic risk. Am. J. Hum. Biol. 28:619-626, 2016. (c) 2016 Wiley Periodicals, Inc.
Filiaciones:
Pena, GG:
Univ Fed Uberlandia, Sch Med, 1720 Para Ave, BR-38400902 Uberlandia, MG, Brazil
Univ Fed Minas Gerais, Sch Nursing, Dept Maternal & Child Nursing & Publ Hlth, 190 Alfredo Balena Ave, BR-30130100 Belo Horizonte, MG, Brazil
Martinez-Perez, A:
St Pau Inst Biomed Res IIB St Pau, Unit Genom Complex Dis, 167 St Antoni M Claret, Barcelona 08025, Spain
Dutra, MS:
Univ Fed Minas Gerais, Inst Biol Sci, 6627 Pres Antonio Carlos Ave, BR-31270901 Belo Horizonte, MG, Brazil
Gazzinelli, A:
Univ Fed Uberlandia, Sch Med, 1720 Para Ave, BR-38400902 Uberlandia, MG, Brazil
Correa-Oliveira, R:
Ctr Pequisas Rene Rachou FIOCRUZ, Cellular & Mol Immunol Lab, 1715 Augusto de Lima, BR-30190002 Belo Horizonte, MG, Brazil
Soria, JM:
St Pau Inst Biomed Res IIB St Pau, Unit Genom Complex Dis, 167 St Antoni M Claret, Barcelona 08025, Spain
Velasquez-Melendez, G:
Univ Fed Minas Gerais, Sch Nursing, Dept Maternal & Child Nursing & Publ Hlth, 190 Alfredo Balena Ave, BR-30130100 Belo Horizonte, MG, Brazil
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