Activity of Ceftazidime-Avibactam against Clinical and Isogenic Laboratory Pseudomonas aeruginosa Isolates Expressing Combinations of Most Relevant beta-Lactam Resistance Mechanisms
Por:
Torrens, G, Cabot, G, Ocampo-Sosa, AA, Conejo, MC, Zamorano, L, Navarro, F, Pascual, A, Martinez-Martinez, L, Oliver, A
Publicada:
1 oct 2016
Resumen:
The activity of ceftazidime-avibactam was compared with that of ceftazidime alone and meropenem against a collection of 190 Pseudomonas aeruginosa clinical isolates recovered from a multicenter study of bloodstream infections. The addition of avibactam increased ceftazidime susceptibility in the complete collection of strains (64.7% to 91.1%) and particularly among subsets of isolates showing AmpC hyperproduction (10.9% to 76.1%) or multidrug resistance (MDR) profiles (27% to 77.8%). The MICs of ceftazidime-avibactam, in contrast with those of ceftazidime or meropenem, remained at <= 4 mu g/ ml for a panel of 16 P. aeruginosa PAO1 isogenic mutants expressing multiple combinations of the most relevant beta-lactam resistance mechanisms.
Filiaciones:
Torrens, G:
IdISPa, Hosp Univ Son Espases, Serv Microbiol, Palma de Mallorca, Spain
IdISPa, Hosp Univ Son Espases, Unidad Invest, Palma de Mallorca, Spain
Spanish Network Res Infect Dis REIPI, Seville, Spain
Cabot, G:
IdISPa, Hosp Univ Son Espases, Serv Microbiol, Palma de Mallorca, Spain
IdISPa, Hosp Univ Son Espases, Unidad Invest, Palma de Mallorca, Spain
Spanish Network Res Infect Dis REIPI, Seville, Spain
Ocampo-Sosa, AA:
Spanish Network Res Infect Dis REIPI, Seville, Spain
IDIVAL, Hosp Univ Marques Valdecilla, Serv Microbiol, Santander, Spain
Conejo, MC:
Spanish Network Res Infect Dis REIPI, Seville, Spain
Univ Seville, IBiS, Hosp Univ Virgen Macarena, Seville, Spain
Zamorano, L:
IdISPa, Hosp Univ Son Espases, Serv Microbiol, Palma de Mallorca, Spain
Spanish Network Res Infect Dis REIPI, Seville, Spain
Navarro, F:
Spanish Network Res Infect Dis REIPI, Seville, Spain
Hosp Santa Creu & Sant Pau, Serv Microbiol, Barcelona, Spain
Pascual, A:
Spanish Network Res Infect Dis REIPI, Seville, Spain
Univ Seville, IBiS, Hosp Univ Virgen Macarena, Seville, Spain
Martinez-Martinez, L:
Spanish Network Res Infect Dis REIPI, Seville, Spain
IDIVAL, Hosp Univ Marques Valdecilla, Serv Microbiol, Santander, Spain
Univ Cantabria, Dept Biol Mol, Santander, Spain
Oliver, A:
IdISPa, Hosp Univ Son Espases, Serv Microbiol, Palma de Mallorca, Spain
IdISPa, Hosp Univ Son Espases, Unidad Invest, Palma de Mallorca, Spain
Spanish Network Res Infect Dis REIPI, Seville, Spain
Green Published, Bronze
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