Short, full-dose adjuvant chemotherapy (CT) in high-risk adult soft tissue sarcomas (STS): long-term follow-up of a randomized clinical trial from the Italian Sarcoma Group and the Spanish Sarcoma Group
Por:
Gronchi, A, Stacchiotti, S, Verderio, P, Ferrari, S, Broto, JM, Lopez-Pousa, A, Llombart-Bosch, A, Tos, APD, Collini, P, Jurado, JC, De Paoli, A, Donati, DM, Poveda, A, Quagliuolo, V, Comandone, A, Grignani, G, Morosi, C, Messina, A, De Sanctis, R, Bottelli, S, Palassini, E, Casali, PG, Picci, P
Publicada:
1 dic 2016
Resumen:
Background: To report on long-term results of a phase 3 trial comparing three versus five cycles of adjuvant chemotherapy (CT) with full-dose epirubicin+ifosfamide in high-risk soft tissue sarcomas (STS).
Methods: Patients (pts) were randomized to receive three preoperative cycles of epirubicin 120 mg/m(2) and ifosfamide 9 g/m(2) (Arm A) or to receive the same three preoperative cycles plus two postoperative cycles (Arm B). Radiotherapy could be either delivered in the preoperative or in the postoperative setting. Non-inferiority of the primary end point, OS, was assessed by the confidence interval of the hazard ratio (HR; Arm A/Arm B) derived from Cox model.
Results: Between January 2002 and April 2007, 164 pts were assigned to arm A and 164 to arm B. At a median follow-up (FU) of 117 months (IQ range 103-135 months), 123 deaths were recorded: 58 in Arm A and 65 in Arm B. Ten-year OS was 61% for the entire group of patients: 64% in Arm A and 59% in Arm B. The intention-to-treat analysis confirmed that three cycles were not inferior to five cycles (one-sided 95% upper confidence limit was 1.24). A per protocol analysis was consistent with these results. Pts with leiomyosarcoma and undifferentiated pleomorphic sarcoma (UPS) had the lowest, and the highest response rates, respectively. Consistently, Leiomyosarcoma and UPS had the worse and the best prognosis, respectively.
Conclusions: At a longer FU, the non-inferiority of three cycles of a full-dose conventional CT in comparison to five is confirmed. Response to therapy is also confirmed to be associated with better survival. This regimen is currently tested within an ongoing international trial against three cycles of a neoadjuvant histology-tailored CT (ClinicalTrials.gov Identifier: NCT01710176).
Filiaciones:
Gronchi, A:
Fdn IRCCS Ist Nazl Tumori, Dept Surg, Via Venezian 1, I-20133 Milan, Italy
Stacchiotti, S:
Fdn IRCCS Ist Nazl Tumori, Dept Canc Med, Milan, Italy
Verderio, P:
Fdn IRCCS Ist Nazl Tumori, Unit Med Stat Biometry & Bioinformat, Milan, Italy
Ferrari, S:
Ist Ortoped Rizzoli, Dept Canc Med, Bologna, Italy
Broto, JM:
Hosp Univ Virgen del Rocio, Dept Canc Med, Seville, Spain
Lopez-Pousa, A:
Hosp Santa Creu & Sant Pau, Dept Canc Med, Barcelona, Spain
Llombart-Bosch, A:
Univ Valencia, Sch Med, Dept Pathol, Valencia, Spain
Tos, APD:
Treviso Gen Hosp, Dept Pathol, Treviso, Italy
Collini, P:
Fdn IRCCS Ist Nazl Tumori, Dept Pathol, Milan, Italy
Jurado, JC:
Univ Canarias Hosp, Dept Canc Med, San Cristobal la Laguna, Spain
De Paoli, A:
Ctr Riferimento Oncol, Dept Radiat Oncol, Aviano, Italy
Donati, DM:
Ist Ortoped Rizzoli, Dept Orthoped Oncol, Bologna, Italy
Poveda, A:
Valencian Oncol Inst, Dept Canc Med, Valencia, Spain
Quagliuolo, V:
Humanitas Canc Ctr, Dept Surg, Rozzano, Italy
Comandone, A:
Presidio Sanit Gradenigo, Dept Canc Med, Turin, Italy
Grignani, G:
IRCC Fdn Piemontese Ric Cancro, Dept Canc Med, Candiolo, Italy
Morosi, C:
Fdn IRCCS Ist Nazl Tumori, Dept Radiol, Milan, Italy
Messina, A:
Fdn IRCCS Ist Nazl Tumori, Dept Radiol, Milan, Italy
De Sanctis, R:
Humanitas Canc Ctr, Dept Canc Med, Rozzano, Italy
Bottelli, S:
Fdn IRCCS Ist Nazl Tumori, Unit Med Stat Biometry & Bioinformat, Milan, Italy
Palassini, E:
Fdn IRCCS Ist Nazl Tumori, Dept Canc Med, Milan, Italy
Casali, PG:
Fdn IRCCS Ist Nazl Tumori, Dept Canc Med, Milan, Italy
Picci, P:
Ist Ortoped Rizzoli, Lab Oncol Res, Bologna, Italy
Bronze
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