SEOM Clinical Guideline of management of soft-tissue sarcoma (2016)
Por:
Lopez-Pousa, A, Broto, JM, Trufero, JM, Sevilla, I, Valverde, C, Alvarez, R, Alvarez, JAC, Jurado, JC, Hindi, N, del Muro, XG
Publicada:
1 dic 2016
Resumen:
Soft-tissue sarcomas are uncommon and heterogeneous tumors of mesenchymal origin. A soft-tissue mass that is increasing in size, greater than 5 cm, or located under deep fascia are criteria for suspicion of sarcoma. Diagnosis, treatment, and management should preferably be performed by a multidisciplinary team in reference centers. MRI and lung CT scan are mandatory for local and distant assessment. A biopsy indicating histological type and grade is needed previous to the treatment. Wide surgical resection with tumor-free tissue margin is the primary treatment for localized disease. Radiotherapy is indicated in large, deep, high-grade tumors, or after marginal resection not likely of being improved with reexcision. Neoadjuvant and adjuvant chemotherapy improve survival in selected cases, usually in high-grade sarcomas of the extremities. In the case of metastatic disease, patients with exclusive lung metastasis could be considered for surgery. First-line treatment with anthracyclines (or in combination with ifosfamide) is the treatment of choice. New drugs have shown activity in second-line therapy and in specific histological subtypes.
Filiaciones:
Lopez-Pousa, A:
Hosp Santa Creu & Sant Pau, Serv Oncol Med, Mas Casanovas 90, Barcelona 08041, Spain
Broto, JM:
Hosp Virgen del Rocio, Seville, Spain
Trufero, JM:
Hosp Univ Miguel Servet, Zaragoza, Spain
Sevilla, I:
Hosp Univ Virgen de la Victoria, Malaga, Spain
Valverde, C:
Hosp Vall dHebro, Barcelona, Spain
Alvarez, R:
Hosp Univ Gregorio Maranon, Madrid, Spain
Alvarez, JAC:
Hosp Univ Vigo, Vigo, Spain
Jurado, JC:
Hosp Univ Canarias, Tenerife, Spain
Hindi, N:
Hosp Virgen del Rocio, Seville, Spain
del Muro, XG:
Hosp Duran & Reynals, Lhospitalet De Llobregat, Spain
Green Published, Hybrid Gold
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