Kidins220 Correlates with Tau in Alzheimer's Disease Brain and Cerebrospinal Fluid
Por:
Gamir-Morralla, A, Belbin, O, Fortea, J, Alcolea, D, Ferrer, I, Lleo, A, Iglesias, T
Publicada:
1 ene 2017
Resumen:
Identification of neurodegeneration-monitoring biomarkers would be of great clinical value for Alzheimer's disease (AD) diagnosis. Using N- or C-terminal antibodies, we studied the pro-survival synaptic effector, Kidins220, in the brain and cerebrospinal fluid (CSF) of controls and AD patients. Only the N-terminal antibody showed a positive correlation between Kidins220 and phosphorylated tau in AD brains. Using this antibody, Kidins220 was detected in CSF from AD patients where it positively correlated with CSF phosphorylated tau and tau. This study highlights the potential of Kidins220 as a CSF biomarker in AD.
Filiaciones:
Gamir-Morralla, A:
Univ Autonoma Madrid, CSIC, Inst Invest Biomed Alberto Sols, Madrid, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, CIBERNED, Madrid, Spain
Belbin, O:
Hosp Santa Creu & Sant Pau, Dept Neurol, Memory Unit, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, CIBERNED, Madrid, Spain
Fortea, J:
Hosp Santa Creu & Sant Pau, Dept Neurol, Memory Unit, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, CIBERNED, Madrid, Spain
Alcolea, D:
Hosp Santa Creu & Sant Pau, Dept Neurol, Memory Unit, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, CIBERNED, Madrid, Spain
Ferrer, I:
Univ Barcelona, IDIBELL Hosp Univ Bellvitge, Inst Neuropatol, Lhospitalet De Llobregat, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, CIBERNED, Madrid, Spain
Lleo, A:
Hosp Santa Creu & Sant Pau, Dept Neurol, Memory Unit, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, CIBERNED, Madrid, Spain
Iglesias, T:
Univ Autonoma Madrid, CSIC, Inst Invest Biomed Alberto Sols, Madrid, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, CIBERNED, Madrid, Spain
Green Accepted
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