Focal temporal pole atrophy and network degeneration in semantic variant primary progressive aphasia
Por:
Collins, JA, Montal, V, Hochberg, D, Quimby, M, Mandelli, ML, Makris, N, Seeley, WW, Gorno-Tempini, ML, Dickerson, BC
Publicada:
1 feb 2017
Resumen:
A wealth of neuroimaging research has associated semantic variant primary progressive aphasia with distributed cortical atrophy that is most prominent in the left anterior temporal cortex; however, there is little consensus regarding which region within the anterior temporal cortex is most prominently damaged, which may indicate the putative origin of neurodegeneration. In this study, we localized the most prominent and consistent region of atrophy in semantic variant primary progressive aphasia using cortical thickness analysis in two independent patient samples (n = 16 and 28, respectively) relative to age-matched controls (n = 30). Across both samples the point of maximal atrophy was located in the same region of the left temporal pole. This same region was the point of maximal atrophy in 100% of individual patients in both semantic variant primary progressive aphasia samples. Using resting state functional connectivity in healthy young adults (n = 89), we showed that the seed region derived from the semantic variant primary progressive aphasia analysis was strongly connected with a large-scale network that closely resembled the distributed atrophy pattern in semantic variant primary progressive aphasia. In both patient samples, the magnitude of atrophy within a brain region was predicted by that region's strength of functional connectivity to the temporopolar seed region in healthy adults. These findings suggest that cortical atrophy in semantic variant primary progressive aphasia may follow connectional pathways within a large-scale network that converges on the temporal pole.
Filiaciones:
Collins, JA:
Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Charlestown, MA USA
Montal, V:
Univ Autonoma Barcelona, Inst Invest Biomed St Pau, Dept Neurol, Hosp St Pau, Barcelona, Spain
Hochberg, D:
Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Charlestown, MA USA
Quimby, M:
Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Charlestown, MA USA
Mandelli, ML:
Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA
Makris, N:
Harvard Med Sch, Massachusetts Gen Hosp, Dept Psychiat, Charlestown, MA USA
Seeley, WW:
Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA
Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94140 USA
Gorno-Tempini, ML:
Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA
Dickerson, BC:
Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Charlestown, MA USA
Green Published, Bronze
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