Familial dilated cardiomyopathy: A multidisciplinary entity, from basic screening to novel circulating biomarkers
Por:
de Gonzalo-Calvo, D, Quezada, M, Campuzano, O, Perez-Serra, A, Broncano, J, Ayala, R, Ramos, M, Llorente-Cortes, V, Blasco-Turrion, S, Morales, FJ, Gonzalez, P, Brugada, R, Mangas, A, Toro, R
Publicada:
1 feb 2017
Resumen:
Idiopathic dilated cardiomyopathy has become one of the most prevalent inherited cardiomyopathies over the past decades. Genetic screening of first-degree relatives has revealed that 30-50% of the cases have a familial origin. Similar to other heart diseases, familial dilated cardiomyopathy is characterized by a high genetic heterogeneity that complicates family studies. Cli'nical screening, 12-lead electrocardiogram and transthoracic echocardiogram are recommended for patients and first-degree family members. Magnetic resonance also needs to be considered. Genetic technologies have become fundamental for the clinical management of this disease. Newgeneration sequencing methods havemade genetic testing feasible for extensive panels of genes related to the disease. Recently, new imaging modalities such as speckle-tracking, strain and strain rate or magnetic resonance, and circulating biomarkers such as non-coding RNAs, have emerged as potential strategies to help cardiologists in their clinical practice. Imaging, genetic and blood-based techniques should be considered together in the evaluation and testing of familial dilated cardiomyopathy. Here, we discuss the current procedures and novel approaches for the clinical management of familial dilated cardiomyopathy. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
Filiaciones:
de Gonzalo-Calvo, D:
Biomed Res Inst Sant Pau IIB St Pau, CSIC ICCC, Cardiovasc Res Ctr, Barcelona, Spain
Quezada, M:
Hosp Univ La Cruz Roja, Madrid, Spain
Campuzano, O:
Univ Girona, Cardiovasc Genet Ctr, IDIBGI, Girona, Spain
Sch Med, Dept Med Sci, Girona, Spain
Perez-Serra, A:
Univ Girona, Cardiovasc Genet Ctr, IDIBGI, Girona, Spain
Broncano, J:
Hosp San Juan Dios Ressalta, Hosp Cruz Roja, Cardiothorac Imaging Sect, Hlth Time Grp, Cordoba, Spain
Ayala, R:
Hosp Univ La Cruz Roja, Madrid, Spain
Ramos, M:
Hosp Univ La Cruz Roja, Madrid, Spain
Llorente-Cortes, V:
Biomed Res Inst Sant Pau IIB St Pau, CSIC ICCC, Cardiovasc Res Ctr, Barcelona, Spain
Blasco-Turrion, S:
Puerto Real Univ Hosp, Dept Cardiol, Cadiz, Spain
Morales, FJ:
Puerto Real Univ Hosp, Dept Cardiol, Cadiz, Spain
Gonzalez, P:
Puerto Real Univ Hosp, Dept Cardiol, Cadiz, Spain
Brugada, R:
Univ Girona, Cardiovasc Genet Ctr, IDIBGI, Girona, Spain
Sch Med, Dept Med Sci, Girona, Spain
Hosp Josep Trueta, Dept Cardiol, Girona, Spain
Mangas, A:
Univ Cadiz, Sch Med, Dept Med, Edificio Andres Segovia 3 Planta, Cadiz 21001, Spain
Toro, R:
Univ Cadiz, Sch Med, Dept Med, Edificio Andres Segovia 3 Planta, Cadiz 21001, Spain
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