Consensus on the management of advanced radioactive iodine-refractory differentiated thyroid cancer on behalf of the Spanish Society of Endocrinology Thyroid Cancer Working Group (GTSEEN) and Spanish Rare Cancer Working Group (GETHI)
Por:
Capdevila, J, Galofre, JC, Grande, E, Llopis, CZ, Asensio, TRYC, Gonzalez, EN, Jimenez-Fonseca, P, Sandi, JS, Saez, JMG, Eizaguirre, GR
Publicada:
1 mar 2017
Resumen:
Thyroid cancer is the single most prevalent endocrine malignancy; differentiated thyroid cancer (DTC) accounts for more than 90 % of all malignancies and its incidence has been rising steadily. For more patients, surgical treatment, radioactive iodine (RAI) ablation, and thyroid-stimulating hormone (TSH) suppressive therapy achieve an overall survival (OS) rate of 97.7 % at 5 years. Nevertheless, locoregional recurrence occurs in up to 20 % and distant metastases in approximately 10 % at 10 years. Two-thirds of these patients will never be cured with radioactive iodine therapy and will become RAI-refractory, with a 3-year OS rate of less than 50 %. Over the last decade, substantial progress has been made in the management of RAI-refractory DTC. Given the controversy in some areas, the Spanish Task Force for Thyroid Cancer on behalf of Spanish Society of Endocrinology Thyroid Cancer Working Group (GTSEEN) and the Spanish Rare Cancer Working Group (GETHI) have created a national joint task force to reach a consensus addressing the most challenging aspects of management in these patients. In this way, multidisciplinary management should be mandatory and nuclear medicine targeted therapy, novel molecular targeted agents, and combinations are currently changing the natural history of RAI-refractory DTC.
Filiaciones:
Capdevila, J:
Hosp Univ Vall dHebron, Vall dHebron Inst Oncol, Dept Med Oncol, Barcelona, Spain
Galofre, JC:
Univ Navarra Clin, Dept Endocrinol & Nutr, Pamplona, Spain
Grande, E:
Hosp Univ Ramon Y Cajal, Dept Med Oncol, Madrid, Spain
Llopis, CZ:
Hosp Univ Vall dHebron, Dept Endocrinol & Nutr, Barcelona, Spain
Asensio, TRYC:
Hosp Univ Santa Creu & St Pau, Dept Med Oncol, Barcelona, Spain
Gonzalez, EN:
Hosp Univ Virgen del Rocio, Dept Endocrinol & Nutr, Seville, Spain
Jimenez-Fonseca, P:
Hosp Univ Cent Asturias, Dept Med Oncol, Oviedo, Spain
Sandi, JS:
Hosp Univ Cruces, Dept Endocrinol & Nutr, Vizcaya, Spain
Saez, JMG:
Hosp Univ Bellvitge, CIBERDEM Serv Endocrinol & Nutr, Barcelona, Spain
Eizaguirre, GR:
Hosp Univ Mostoles, Dept Endocrinol & Nutr, Madrid, Spain
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