Regional Overlap of Pathologies in Lewy Body Disorders
Por:
Colom-Cadena, M, Grau-Rivera, O, Planellas, L, Cerquera, C, Morenas, E, Helgueta, S, Munoz, L, Kulisevsky, J, Marti, MJ, Tolosa, E, Clarimon, J, Lleo, A, Gelpi, E
Publicada:
1 mar 2017
Resumen:
Lewy body disorders (LBD) are common neurodegenerative diseases characterized by the presence of aggregated proportional to-synuclein in Lewy bodies and Lewy neurites in the central and peripheral nervous systems. The brains of patients with LBD often display other comor-bid pathologies, i. e. insoluble tau, beta-amyloid aggregates, TAR DNA-binding protein 43 (TDP-43) deposits, and argyrophilic grain disease (AGD). The incidence and physiological relevance of these concurrent pathological findings remain controversial. We per-formed a semiquantitative detailed mapping of proportional to-synuclein, tau, beta-amyloid (A beta), TDP-43, and AGD pathologies in 17 areas in 63 LBD cases (44 with Parkinson disease [PD], 28 with dementia, and 19 with dementia with Lewy bodies). APOE and MAPT genetic variants were also investigated. A majority of LBD cases had 2 or 3 concomitant findings, particularly Alzheimer disease-related pathology. Pathological stages of tau, beta-amyloid and proportional to-synuclein pathologies were increased in cases with dementia. A beta score was the best correlate of the time to dementia in PD. In addition, beta-amyloid deposition correlated with beta-synuclein load in all groups. MAPT H1 haplotype did not influence any assessed pathology in PD. These results highlight the common concurrence of pathologies in patients with LBD that may have an impact on the clinical expression of the diseases.
Filiaciones:
Colom-Cadena, M:
Univ Autonoma Barcelona, Hosp St Pau, Inst Invest Biomed St Pau, Dept Neurol, Barcelona, Spain
CIBERNED, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Grau-Rivera, O:
Biobanc Hosp Clin IDIBAPS, Neurol Tissue Bank, C Casanova 143,Planta 0, Barcelona 08036, Spain
Planellas, L:
Univ Barcelona, Hosp Clin, Parkinsons Dis & Movement Disorders Unit, Barcelona, Spain
Cerquera, C:
Univ Barcelona, Hosp Clin, Parkinsons Dis & Movement Disorders Unit, Barcelona, Spain
Pontificia Univ Javeriana, Sch Med, Hosp Univ San Ignacio, Neurol Unit, Bogota, Colombia
Autonomous Univ Barcelona, Univ Oberta Catalunya, Movement Disorders Unit, Neurol Dept,Hosp St Pau, Barcelona, Spain
Morenas, E:
Univ Autonoma Barcelona, Hosp St Pau, Inst Invest Biomed St Pau, Dept Neurol, Barcelona, Spain
CIBERNED, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Helgueta, S:
Univ Autonoma Barcelona, Hosp St Pau, Inst Invest Biomed St Pau, Dept Neurol, Barcelona, Spain
CIBERNED, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Munoz, L:
Univ Autonoma Barcelona, Hosp St Pau, Inst Invest Biomed St Pau, Dept Neurol, Barcelona, Spain
CIBERNED, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Kulisevsky, J:
CIBERNED, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Marti, MJ:
CIBERNED, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Univ Barcelona, Hosp Clin, Parkinsons Dis & Movement Disorders Unit, Barcelona, Spain
Tolosa, E:
CIBERNED, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Biobanc Hosp Clin IDIBAPS, Neurol Tissue Bank, C Casanova 143,Planta 0, Barcelona 08036, Spain
Clarimon, J:
Univ Autonoma Barcelona, Hosp St Pau, Inst Invest Biomed St Pau, Dept Neurol, Barcelona, Spain
CIBERNED, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Lleo, A:
Univ Autonoma Barcelona, Hosp St Pau, Inst Invest Biomed St Pau, Dept Neurol, Barcelona, Spain
CIBERNED, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Gelpi, E:
Biobanc Hosp Clin IDIBAPS, Neurol Tissue Bank, C Casanova 143,Planta 0, Barcelona 08036, Spain
Green Published, Bronze
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