Cannabis use, COMT, BDNF and age at first-episode psychosis
Por:
Mane, A, Berge, D, Penzol, MJ, Parellada, M, Bioque, M, Lobo, A, Gonzalez-Pinto, A, Corripio, I, Cabrera, B, Sanchez-Torres, AM, Saiz-Ruiz, J, Bernardo, M
Publicada:
1 abr 2017
Resumen:
Although an interaction between COMTVal158Met and BDNF Val66Met polymorphisms with cannabis use has been proposed with respect to the risk of psychosis emergence, findings remain inconclusive. The aim of the present study was to evaluate the different possible associations between these polymorphisms and early cannabis use and the age at the first episode of psychosis. The relationship between age at psychosis onset and COMTVal158Met and BDNF Val66Met polymorphisms with early cannabis use as well as those factors associated with early cannabis use were investigated. Among 260 Caucasian first-episode psychosis patients, early cannabis use and the presence of the met-allele from the BDNFVal66Met polymorphism were significantly associated with age at psychosis onset. Furthermore, early cannabis use was significantly associated with male gender in the logistic regression analysis. These findings provide evidence of the important role of early cannabis use and the Val66Met BDNF polymorphism on age at psychosis onset and they point out to sex specific differences in cannabis use patterns.
Filiaciones:
Mane, A:
Hosp Mar, Med Res Inst IMIM, Dept Neurosci & Psychiat, Barcelona, Spain
Ctr Invest Red Salud Mental CIBERSAM, Passeig Maritim Barceloneta 25-29, Madrid 08003, Spain
Berge, D:
Hosp Mar, Med Res Inst IMIM, Dept Neurosci & Psychiat, Barcelona, Spain
Ctr Invest Red Salud Mental CIBERSAM, Passeig Maritim Barceloneta 25-29, Madrid 08003, Spain
Penzol, MJ:
Ctr Invest Red Salud Mental CIBERSAM, Passeig Maritim Barceloneta 25-29, Madrid 08003, Spain
Univ Gregorio Maranon, Gen Hosp, Child & Adolescent Psychiat Dept, IiSGM, Madrid, Spain
Parellada, M:
Ctr Invest Red Salud Mental CIBERSAM, Passeig Maritim Barceloneta 25-29, Madrid 08003, Spain
Univ Gregorio Maranon, Gen Hosp, Child & Adolescent Psychiat Dept, IiSGM, Madrid, Spain
Univ Complutense, Sch Med, Madrid, Spain
Bioque, M:
Ctr Invest Red Salud Mental CIBERSAM, Passeig Maritim Barceloneta 25-29, Madrid 08003, Spain
Hosp Clin Barcelona, Barcelona Clin, Schizophrenia Unit, Barcelona, Spain
Lobo, A:
Ctr Invest Red Salud Mental CIBERSAM, Passeig Maritim Barceloneta 25-29, Madrid 08003, Spain
Univ Zaragoza, Dept Psychiat, HS Aragon, Zaragoza, Spain
Gonzalez-Pinto, A:
Ctr Invest Red Salud Mental CIBERSAM, Passeig Maritim Barceloneta 25-29, Madrid 08003, Spain
Univ Basque Country, Univ Hosp Alava Santiago, Dept Psychiat, Vitoria, Spain
Corripio, I:
Ctr Invest Red Salud Mental CIBERSAM, Passeig Maritim Barceloneta 25-29, Madrid 08003, Spain
Univ Autonoma Barcelona, Barcelona, Spain
Hosp Santa Creu & Sant Pau, Inst Invest Biomed Sant Pau, Dept Psychiat, Barcelona, Spain
Cabrera, B:
Ctr Invest Red Salud Mental CIBERSAM, Passeig Maritim Barceloneta 25-29, Madrid 08003, Spain
Hosp Clin Barcelona, Barcelona Clin, Schizophrenia Unit, Barcelona, Spain
Sanchez-Torres, AM:
Complejo Hosp Navarra, Dept Psychiat, Pamplona, Spain
Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain
Saiz-Ruiz, J:
Ctr Invest Red Salud Mental CIBERSAM, Passeig Maritim Barceloneta 25-29, Madrid 08003, Spain
Univ Alcala De Henares, Hosp Ramon & Cajal, Dept Psychiat, IRYCIS, Madrid, Spain
Bernardo, M:
Ctr Invest Red Salud Mental CIBERSAM, Passeig Maritim Barceloneta 25-29, Madrid 08003, Spain
Hosp Clin Barcelona, Barcelona Clin, Schizophrenia Unit, Barcelona, Spain
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