How Phenotype Guides Management of the Most Common Malignant Salivary Neoplasms of the Larynx?
Por:
Lopez, F, Williams, MD, Skalova, A, Hellquist, H, Suarez, C, Nixon, IJ, Rodrigo, JP, Cardesa, A, Strojan, P, Quer, M, Hunt, JL, Rinaldo, A, Ferlito, A
Publicada:
1 abr 2017
Resumen:
Salivary gland carcinomas of the larynx are uncommon. Adenoid cystic carcinoma is the most prevalent type of salivary gland carcinoma in this region, although other histologies such as mucoepidermoid carcinoma and adenocarcinomas have been reported. These tumors may present with advanced-stage due to nonspecific symptoms and their relatively slow-growing nature. The index of suspicion for a non-squamous cell carcinoma entity should be high when a submucosal mass is present. An accurate diagnosis is mandatory due to the impact each biologic entity has on treatment and outcome. Data concerning treatment and outcome are scarce, but primary surgery with utmost focus on free surgical margins is the treatment of choice. The role of adjuvant radiotherapy has not been well defined, although there is an agreement that it should be considered in advanced-stage or high-grade disease. This review considers only the most common malignant salivary neoplasms of the larynx with a focus on clinical management of these tumors.
Filiaciones:
Lopez, F:
Hosp Univ Cent Asturias, Dept Otolaryngol, Oviedo, Spain
Univ Oviedo, ISCIII, Inst Univ Oncol Principado Asturias, Inst Invest Sanitaria Principado Asturias & CIBER, Oviedo, Spain
Williams, MD:
Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA
Skalova, A:
Charles Univ Prague, Fac Med Plzen, Dept Pathol, Plzen, Czech Republic
Hellquist, H:
Univ Algarve, Dept Biomed Sci & Med, Faro, Portugal
Suarez, C:
Univ Oviedo, ISCIII, Inst Univ Oncol Principado Asturias, Inst Invest Sanitaria Principado Asturias & CIBER, Oviedo, Spain
Nixon, IJ:
Univ Edinburgh, Dept Surg, Edinburgh, Midlothian, Scotland
Univ Edinburgh, Dept Otolaryngol Head & Neck Surg, Edinburgh, Midlothian, Scotland
Rodrigo, JP:
Hosp Univ Cent Asturias, Dept Otolaryngol, Oviedo, Spain
Univ Oviedo, ISCIII, Inst Univ Oncol Principado Asturias, Inst Invest Sanitaria Principado Asturias & CIBER, Oviedo, Spain
Cardesa, A:
Univ Barcelona, Hosp Clin, Dept Anat Pathol, Barcelona, Spain
Strojan, P:
Inst Oncol, Dept Radiat Oncol, Ljubljana, Slovenia
Quer, M:
Hosp Santa Creu & Sant Pau, Dept Otolaryngol, Barcelona, Spain
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