Asthma outcomes improve with continuous positive airway pressure for obstructive sleep apnea
Por:
Serrano-Pariente, J, Plaza, V, Soriano, JB, Mayos, M, Lopez-Vina, A, Picado, C, Vigil, L
Publicada:
1 may 2017
Resumen:
BackgroundContinuous positive airway pressure (CPAP) in asthma patients with concomitant obstructive sleep apnea syndrome (OSAS) seems to have a favorable impact on asthma, but data are inconsistent due to methodological limitations of previous studies.
MethodsProspective, multicenter study. We examined asthma outcomes after 6 months of CPAP in 99 adult asthma patients (mean age 57 years) with OSAS (respiratory disturbance index 20). Asthma control and quality of life were assessed with the Asthma Control Questionnaire (ACQ) and the Mini Asthma Quality of Life Questionnaire (MiniAQLQ), respectively. Data were analyzed by intention-to-treat basis.
ResultsThe mean SD score of the ACQ decreased from 1.39 +/- 0.91 at baseline to 1.0 +/- 0.78 at 6 months (P = 0.003), the percentage of patients with uncontrolled asthma from 41.4% to 17.2% (P = 0.006), and the percentage of patients with asthma attacks in the 6 months before and after treatment from 35.4% to 17.2% (P = 0.015). The score of the mAQLQ increased from 5.12 +/- 1.38 to 5.63 +/- 1.17 (P = 0.009). There were also significant improvements in symptoms of gastroesophageal reflux and rhinitis, bronchial reversibility, and exhaled nitric oxide values (all P < 0.05). No significant changes were observed in drug therapy for asthma or their comorbidities nor in the patients' weight.
ConclusionsAsthma control (both actual and future risk), quality of life, and lung function improved after starting continuous positive airway pressure in asthmatics with moderate to severe obstructive sleep apnea syndrome.
Filiaciones:
Serrano-Pariente, J:
Hosp Comarcal Inca, Pneumol Dept, Carretera Vella Llubi S-N, E-07300 Inca, Balearic Island, Spain
Spanish Soc Pneumol & Thorac Surg SEPAR, Area Asma, GEA, Barcelona, Spain
Plaza, V:
Univ Autonoma Barcelona, IIB St Pau, Hosp Santa Creu & St Pau, Pneumol Dept, Barcelona, Spain
Soriano, JB:
Univ Autonoma Madrid, Inst Invest Hosp Univ Princesa, Catedra UAM Linde, Madrid, Spain
Mayos, M:
Univ Autonoma Barcelona, IIB St Pau, Hosp Santa Creu & St Pau, Pneumol Dept, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain
Lopez-Vina, A:
Hosp Univ Puerta de Hierro, Pneumol Dept, Madrid, Spain
Picado, C:
Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain
Univ Barcelona, Hosp Clin Barcelona, Dept Pneumol, Barcelona, Spain
Vigil, L:
Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain
Corp Sanitaria Parc Tauli, Serv Pneumol, Barcelona, Spain
Green Published, Hybrid Gold
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