Docetaxel in prostate cancer: a familiar face as the new standard in a hormone-sensitive setting
Por:
Puente, J, Grande, E, Medina, A, Maroto, P, Lainez, N, Arranz, JA
Publicada:
1 may 2017
Resumen:
The increasing knowledge of prostate cancer is leading to many questions about its natural history and to reconsider conventional therapeutic strategies. Androgen ablation therapy has been the standard therapy in the advanced setting. Although docetaxel has demonstrated increased survival in patients with metastatic prostate cancer who had progressed to hormone treatments, due to its potential toxicity the role of chemotherapy has been relegated to patients who were symptomatic or who had high tumor burden. Several studies have assessed whether docetaxel could have a role in hormone-sensitive disease or even in earlier stages with no distant metastases. In the CHAARTED and STAMPEDE studies, docetaxel provides an unprecedented increase in overall survival (OS). This review summarizes the evidence behind the paradigm shift to strengthening docetaxel as a new standard of treatment that prolongs survival in earlier stages of prostate cancer.
Filiaciones:
Puente, J:
Hosp Clin Univ San Carlos, Med Oncol Dept, C Prof Martin Lagos S-N, Madrid 28040, Spain
Grande, E:
Hosp Univ Ramon y Cajal, Madrid, Spain
Medina, A:
Ctr Oncol Galicia, La Coruna, Spain
Maroto, P:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Lainez, N:
Hosp Navarra, Pamplona, Spain
Arranz, JA:
Hosp Gregorio Maranon, Madrid, Spain
Gold, Green Published
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