Reporting and Staging of Testicular Germ Cell Tumors The International Society of Urological Pathology (ISUP) Testicular Cancer Consultation Conference Recommendations
Por:
Verrill, C, Yilmaz, A, Srigley, JR, Amin, MB, Comperat, E, Egevad, L, Ulbright, TM, Tickoo, SK, Berney, DM, Epstein, JI, Delahunt, B, Magi-Galluzzi, C, Algaba, F, Oliva, E, Montironi, R, Young, RH, Idrees, MT, Williamson, SR, Zhou, M, Humphrey, PA, Lopez-Beltran, A, Perry-Keene, J, Members Int Soc Urological
Publicada:
1 jun 2017
Resumen:
The International Society of Urological Pathology held a conference devoted to issues in testicular and penile pathology in Boston in March 2015, which included a presentation and discussion led by the testis microscopic features working group. This conference focused on controversies related to staging and reporting of testicular tumors and was preceded by an online survey of the International Society of Urological Pathology members. The survey results were used to initiate discussions, but decisions were made by expert consensus rather than voting. A number of recommendations emerged from the conference, including that lymphovascular invasion (LVI) should always be reported and no distinction need be made between lymphatic or blood invasion. If LVI is equivocal, then it should be regarded as negative to avoid triggering unnecessary therapy. LVI in the spermatic cord is considered as category pT2, not pT3, unless future studies provide contrary evidence. At the time of gross dissection, a block should be taken just superior to the epididymis to define the base of the spermatic cord, and direct invasion of tumor in this block indicates a category of pT3. Pagetoid involvement of the rete testis epithelium must be distinguished from rete testis stromal invasion, with only the latter being prognostically useful. Percentages of different tumor elements in mixed germ cell tumors should be reported. Although consensus was reached on many issues, there are still areas of practice that need further evidence on which to base firm recommendations.
Filiaciones:
Verrill, C:
Univ Oxford, Nuffield Dept Surg Sci, Oxford, England
Yilmaz, A:
Calgary Lab Serv, Dept Pathol & Lab Med, Calgary, AB, Canada
Univ Calgary, Calgary, AB, Canada
Srigley, JR:
Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada
Amin, MB:
Cedars Sinai Med Ctr, Dept Pathol & Lab Med, Los Angeles, CA 90048 USA
Comperat, E:
Univ Paris 06, Hop Tenon, AP HP, Dept Pathol, Paris, France
Egevad, L:
Karolinska Hosp, Dept Pathol & Cytol, Stockholm, Sweden
Ulbright, TM:
Indiana Univ Sch Med, Dept Pathol & Lab Med, Indianapolis, IN 46202 USA
Tickoo, SK:
Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10021 USA
Berney, DM:
Queen Mary Univ London, Barts Canc Inst, Dept Mol Oncol, London, England
Epstein, JI:
Johns Hopkins Univ Hosp, Dept Pathol, Baltimore, MD USA
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