Secukinumab is Efficacious and Safe in Hispanic Patients with Moderate-to-Severe Plaque Psoriasis: Pooled Analysis of Four Phase 3 Trials
Por:
Adsit, S, Zaldivar, ER, Sofen, H, Dei-Cas, I, Maldonado-Garcia, C, Penaranda, EO, Puig, L, Meng, XY, Fox, T, Guana, A
Publicada:
1 jun 2017
Resumen:
There is little evidence available on the efficacy and safety of biologic therapies for the treatment of psoriasis in Hispanic patients. Secukinumab is demonstrated to be highly effective for clearing psoriasis. The aim of this study was to compare the efficacy and safety of secukinumab in Hispanic and non-Hispanic patients.
Data were pooled from four phase 3 studies of secukinumab in patients with moderate-to-severe plaque psoriasis. Patients who self-identified as Hispanic were included in the Hispanic subgroup.
Efficacy responses (Psoriasis Area and Severity Index [PASI] 75/90/100 and Investigator's Global Assessment 2011 modified version 0/1) for secukinumab 300 mg were greater than for etanercept at week 12 in the Hispanic and non-Hispanic patient subgroups. At week 12 with secukinumab 300 mg, PASI 90/100 responses were achieved by 70.6%/35.9% of Hispanic patients and 58.0%/28.1% of non-Hispanic patients. At week 12 with secukinumab 150 mg, PASI 90/100 responses were achieved by 59.5%/25.1% of Hispanic patients and 41.2%/13.4% of non-Hispanic patients. In both subgroups, peak efficacy responses with secukinumab were observed at week 16 and were maintained to week 52.
Secukinumab is highly effective for clearing psoriasis in both Hispanic and non-Hispanic patients.
Novartis Pharmaceutical Corporation.
Filiaciones:
Adsit, S:
TCR Med Corp, San Diego, CA 92123 USA
Zaldivar, ER:
Dermos, Guatemala City, Guatemala
Sofen, H:
UCLA Sch Med, Los Angeles, CA USA
Dei-Cas, I:
Halitus, Buenos Aires, DF, Argentina
Maldonado-Garcia, C:
Ctr Dermatol Dr Ladislao de la Pascua, Mexico City, DF, Mexico
Penaranda, EO:
Riesgo Fractura SA, Bogota, Colombia
Puig, L:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Barcelona, Spain
Meng, XY:
Novartis Pharmaceut, E Hanover, NJ USA
Fox, T:
Novartis Pharma AG, Basel, Switzerland
Guana, A:
Novartis Pharmaceut, E Hanover, NJ USA
Hybrid Gold, Green Published
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