Management of Localized Muscle-Invasive Bladder Cancer from a Multidisciplinary Perspective: Current Position of the Spanish Oncology Genitourinary (SOGUG) Working Group
Por:
Caamano, AG, Vicente, AMGM, Maroto, P, Antolin, AR, Sanz, J, Gonzalez, MAV, Climent, MA
Publicada:
1 dic 2021
Resumen:
This review presents challenges and recommendations on different aspects related to the management of patients with localized muscle-invasive bladder cancer (MIBC), which were discussed by a group of experts of a Spanish Oncology Genitourinary (SOGUG) Working Group within the framework of the Genitourinary Alliance project (12GU). It is necessary to clearly define which patients are candidates for radical cystectomy and which are candidates for undergoing bladder-sparing procedures. In older patients, it is necessary to include a geriatric assessment and evaluation of comorbidities. The pathological report should include a classification of the histopathological variant of MIBC, particularly the identification of subtypes with prognostic, molecular and therapeutic implications. Improvement of clinical staging, better definition of prognostic groups based on molecular subtypes, and identification of biomarkers potentially associated with maximum benefit from neoadjuvant chemotherapy are areas for further research. A current challenge in the management of MIBC is improving the selection of patients likely to be candidates for immunotherapy with checkpoint inhibitors in the neoadjuvant setting. Optimization of FDG-PET/CT reliability in staging of MIBC and the selection of patients is necessary, as well as the design of prospective studies aimed to compare the value of different imaging techniques in parallel.
Filiaciones:
Caamano, AG:
Hosp Clin Univ Santiago, Dept Radiat Oncol, Santiago De Compostela 15706, Spain
Vicente, AMGM:
Univ Gen Hosp, Nucl Med Dept, Ciudad Real 13005, Spain
Maroto, P:
Hosp Santa Creu & Sant Pau, Barcelona 08041, Spain
Antolin, AR:
Hosp Univ 12 Octubre, Urol Serv, Madrid 28041, Spain
Sanz, J:
Clin Univ Navarra, Pamplona 31008, Spain
Gonzalez, MAV:
Hosp Clin Univ Valencia, Radiol Dept, Valencia 46010, Spain
Climent, MA:
Fdn Inst Valenciano Oncol, Med Oncol Serv, Valencia 46009, Spain
gold, Green Published
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