Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson's disease
Por:
Martinez-Horta, S, Bejr-Kasem, H, Horta-Barba, A, Pascual-Sedano, B, Santos-Garcia, D, De Deus-Fonticoba, T, Jesus, S, Aguilar, M, Planellas, L, Garcia-Caldentey, J, Caballol, N, Vives-Pastor, B, Hernandez-Vara, J, Cabo-Lopez, I, Lopez-Manzanares, L, Gonzalez-Aramburu, I, Avila-Rivera, MA, Catalan, MJ, Lopez-Diaz, LM, Puente, V, Garcia-Moreno, JM, Borrue, C, Solano-Vila, B, Alvarez-Sauco, M, Vela, L, Escalante, S, Cubo, E, Carrillo-Padilla, F, Martinez-Castrillo, JC, Sanchez-Alonso, P, Alonso-Losada, MG, Lopez-Ariztegui, N, Gaston, I, Blazquez-Estrada, M, Seijo-Martinez, M, Ruiz-Martinez, J, Valero-Merino, C, Kurtis, M, De Fabregues-Boixar, O, Gonzalez-Ardura, J, Prieto-Jurczynska, C, Martinez-Martin, P, Mir, P, Kulisevsky, J
Publicada:
8 dic 2021
Resumen:
Background Identifying modifiable risk factors for cognitive impairment in the early stages of Parkinson's disease (PD) and estimating their impact on cognitive status may help prevent dementia (PDD) and the design of cognitive trials. Methods Using a standard approach for the assessment of global cognition in PD and controlling for the effects of age, education and disease duration, we explored the associations between cognitive status, comorbidities, metabolic variables and lifestyle variables in 533 PD participants from the COPPADIS study. Results Among the overall sample, 21% of participants were classified as PD-MCI (n = 114) and 4% as PDD (n = 26). The prevalence of hypertension, diabetes and dyslipidemia was significantly higher in cognitively impaired patients while no between-group differences were found for smoking, alcohol intake or use of supplementary vitamins. Better cognitive scores were significantly associated with regular physical exercise (p < 0.05) and cognitive stimulation (< 0.01). Cognitive performance was negatively associated with interleukin 2 (Il2) (p < 0.05), Il6 (p < 0.05), iron (p < 0.05), and homocysteine (p < 0.005) levels, and positively associated with vitamin B12 levels (p < 0.005). Conclusions We extend previous findings regarding the positive and negative influence of various comorbidities and lifestyle factors on cognitive status in early PD patients, and reinforce the need to identify and treat potentially modifiable variables with the intention of exploring the possible improvement of the global cognitive status of patients with PD.
Filiaciones:
Martinez-Horta, S:
Hosp Santa Creu & Sant Pau, Movement Disorders Unit, Neurol Dept, Mas Casanovas 90, Barcelona 08041, Spain
IIB St Pau, Biomed Res Inst St Pau, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat CIBERN, Madrid, Spain
Bejr-Kasem, H:
Hosp Santa Creu & Sant Pau, Movement Disorders Unit, Neurol Dept, Mas Casanovas 90, Barcelona 08041, Spain
IIB St Pau, Biomed Res Inst St Pau, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat CIBERN, Madrid, Spain
Horta-Barba, A:
Hosp Santa Creu & Sant Pau, Movement Disorders Unit, Neurol Dept, Mas Casanovas 90, Barcelona 08041, Spain
IIB St Pau, Biomed Res Inst St Pau, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat CIBERN, Madrid, Spain
Pascual-Sedano, B:
Hosp Santa Creu & Sant Pau, Movement Disorders Unit, Neurol Dept, Mas Casanovas 90, Barcelona 08041, Spain
IIB St Pau, Biomed Res Inst St Pau, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat CIBERN, Madrid, Spain
Santos-Garcia, D:
Complejo Hosp Univ A Coruna, CHUAC, La Coruna, Spain
De Deus-Fonticoba, T:
Complejo Hosp Univ Ferrol CHUF, Ferrol, A Coruna, Spain
Jesus, S:
Ctr Invest Red Enfermedades Neurodegenerat CIBERN, Madrid, Spain
Univ Seville, Hosp Univ Virgen del Rocio, Inst Biomed Sevilla,CSIC, Unidad Trastornos Movimiento,Serv Neurol & Neuro, Seville, Spain
Aguilar, M:
Hosp Univ Mutua de Terrassa, Barcelona, Spain
Planellas, L:
Hosp Clin Barcelona, Barcelona, Spain
Garcia-Caldentey, J:
Hosp Quiron Palmaplanas, Clin Rotger, Palma De Mallorca, Spain
Ctr Neurol Oms 42, Palma de Mallorca, Spain
Caballol, N:
Hosp Moises Broggi, Consorci Sanitari Integral, Barcelona, Spain
Vives-Pastor, B:
Hosp Univ Son Espases, Palma De Mallorca, Spain
Hernandez-Vara, J:
Vall DHebron Univ Campus, Neurol Dept, Barcelona, Spain
Vall DHebron Univ Campus, Neurodegenerat Dis Res Grp, Barcelona, Spain
Cabo-Lopez, I:
Complejo Hosp Univ Pontevedra CHOP, Pontevedra, Spain
Lopez-Manzanares, L:
Hosp Princesa, Madrid, Spain
Gonzalez-Aramburu, I:
Hosp Univ Marques de Valdecilla, Santander, Spain
Avila-Rivera, MA:
Hosp Moises Broggi, Consorci Sanitari Integral, Barcelona, Spain
Catalan, MJ:
Hosp Univ Clin San Carlos, Madrid, Spain
Lopez-Diaz, LM:
Hosp Costa de Burela, Lugo, Spain
Puente, V:
Hosp Mar, Barcelona, Spain
Garcia-Moreno, JM:
Hosp Univ Virgen Macarena, Seville, Spain
Borrue, C:
Hosp Univ Infanta Sofia, Madrid, Spain
Solano-Vila, B:
Hosp Univ Josep Trueta, Girona, Spain
Hosp Santa Caterina, Girona, Spain
Alvarez-Sauco, M:
Hosp Gen Univ Elche, Alicante, Spain
Vela, L:
Fdn Hosp Alcorcon, Madrid, Spain
Escalante, S:
Hosp Tortosa Verge de la Cinta HTVC, Tarragona, Spain
Cubo, E:
Complejo Asistencial Univ Burgos, Burgos, Spain
Carrillo-Padilla, F:
Hosp Univ Canarias, Serv Neurol & Neurofisiol Clin, Unidad Trastornos Movimiento, Tenerife, Spain
Martinez-Castrillo, JC:
Hosp Ramon & Cajal, Madrid, Spain
Sanchez-Alonso, P:
Hosp Univ Puerta de Hierro, Madrid, Spain
Alonso-Losada, MG:
Complejo Hosp Univ Vigo CHUVI, Hosp Alvaro Cunqueiro, Vigo, Spain
Lopez-Ariztegui, N:
Complejo Hosp Univ Toledo, Serv Neurol, Toledo, Spain
Gaston, I:
Complejo Hosp Navarra, Pamplona, Spain
Blazquez-Estrada, M:
Hosp Univ Cent Asturias, Oviedo, Spain
Seijo-Martinez, M:
Complejo Hosp Univ Pontevedra CHOP, Pontevedra, Spain
Ruiz-Martinez, J:
Hosp Univ Donostia, San Sebastian, Spain
Valero-Merino, C:
Hosp Arnau Vilanova, Serv Neurol, Valencia, Spain
Kurtis, M:
Hosp Ruber Int, Madrid, Spain
De Fabregues-Boixar, O:
Vall DHebron Univ Campus, Neurol Dept, Barcelona, Spain
Vall DHebron Univ Campus, Neurodegenerat Dis Res Grp, Barcelona, Spain
Gonzalez-Ardura, J:
Hosp Lucus Augusti, Lugo, Spain
Prieto-Jurczynska, C:
Hosp Rey Juan Carlos, Madrid, Spain
Martinez-Martin, P:
Ctr Invest Red Enfermedades Neurodegenerat CIBERN, Madrid, Spain
Inst Salud Carlos III, Ctr Nacl Epidemiol, Madrid, Spain
Inst Salud Carlos III, CIBERNED, Madrid, Spain
Mir, P:
Ctr Invest Red Enfermedades Neurodegenerat CIBERN, Madrid, Spain
Univ Seville, Hosp Univ Virgen del Rocio, Inst Biomed Sevilla,CSIC, Unidad Trastornos Movimiento,Serv Neurol & Neuro, Seville, Spain
Univ Seville, Fac Med, Dept Med, Seville, Spain
Kulisevsky, J:
Hosp Santa Creu & Sant Pau, Movement Disorders Unit, Neurol Dept, Mas Casanovas 90, Barcelona 08041, Spain
IIB St Pau, Biomed Res Inst St Pau, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat CIBERN, Madrid, Spain
Green Published, gold
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