Influence of geographical latitude on vitamin D status: cross-sectional results from the BiomarCaRE consortium
Por:
Oskarsson, V, Eliasson, M, Salomaa, V, Reinikainen, J, Mannisto, S, Palmieri, L, Donfrancesco, C, Sans, S, Costanzo, S, de Gaetano, G, Iacoviello, L, Veronesi, G, Ferrario, MM, Padro, T, Thorand, B, Huth, C, Zeller, T, Blankenberg, S, Anderson, AS, Tunstall-Pedoe, H, Kuulasmaa, K, Soderberg, S
Publicada:
14 dic 2022
Ahead of Print:
1 dic 2021
Resumen:
Even though sunlight is viewed as the most important determinant of 25-hydroxyvitamin D (25(OH)D) status, several European studies have observed higher 25(OH)D concentrations among north-Europeans than south-Europeans. We studied the association between geographical latitude (derived from ecological data) and 25(OH)D status in six European countries using harmonised immunoassay data from 81 084 participants in the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) project (male sex 48 center dot 9 %; median age 50 center dot 8 years; examination period 1984-2014). Quantile regression models, adjusted for age, sex, decade and calendar week of sampling and time from sampling to analysis, were used for between-country comparisons. Up until the median percentile, the ordering of countries by 25(OH)D status (from highest to lowest) was as follows: Sweden (at 65 center dot 6-63 center dot 8 degrees N), Germany (at 48 center dot 4 degrees N), Finland (at 65 center dot 0-60 center dot 2 degrees N), Italy (at 45 center dot 6-41 center dot 5 degrees N), Scotland (at 58 center dot 2-55 center dot 1 degrees N) and Spain (at 41 center dot 5 degrees N). From the 75th percentile and upwards, Finland had higher values than Germany. As an example, using the Swedish cohort as a comparator, the median 25(OH)D concentration was 3 center dot 03, 3 center dot 28, 5 center dot 41, 6 center dot 54 and 9 center dot 28 ng/ml lower in the German, Finnish, Italian, Scottish and Spanish cohort, respectively (P-value < 0 center dot 001 for all comparisons). The ordering of countries was highly consistent in subgroup analyses by sex, age, and decade and season of sampling. In conclusion, we confirmed the previous observation of a north-to-south gradient of 25(OH)D status in Europe, with higher percentile values among north-Europeans than south-Europeans.
Filiaciones:
Oskarsson, V:
Umea Univ, Dept Publ Hlth & Clin Med, S-90187 Umea, Sweden
Eliasson, M:
Umea Univ, Dept Publ Hlth & Clin Med, S-90187 Umea, Sweden
Salomaa, V:
Finnish Inst Hlth & Welf, Dept Publ Hlth Solut, Helsinki, Finland
Reinikainen, J:
Finnish Inst Hlth & Welf, Dept Publ Hlth Solut, Helsinki, Finland
Mannisto, S:
Finnish Inst Hlth & Welf, Dept Publ Hlth Solut, Helsinki, Finland
Palmieri, L:
Ist Super Sanita ISS, Dept Cardiovasc Endocrine Metab Dis & Aging, Rome, Italy
Donfrancesco, C:
Ist Super Sanita ISS, Dept Cardiovasc Endocrine Metab Dis & Aging, Rome, Italy
Sans, S:
Catalan Dept Hlth, Barcelona, Spain
Costanzo, S:
IRCCS Neuromed, Dept Epidemiol & Prevent, Pozzilli, Italy
de Gaetano, G:
IRCCS Neuromed, Dept Epidemiol & Prevent, Pozzilli, Italy
Iacoviello, L:
IRCCS Neuromed, Dept Epidemiol & Prevent, Pozzilli, Italy
Univ Insubria, Dept Med & Surg, Varese, Italy
Veronesi, G:
Univ Insubria, Dept Med & Surg, Varese, Italy
Ferrario, MM:
Univ Insubria, Dept Med & Surg, Varese, Italy
Padro, T:
IIB St Pau, Res Inst Hosp Santa Creu & St Pau, Cardiovasc Program ICCC, Barcelona, Spain
Thorand, B:
German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, Neuherberg, Germany
Huth, C:
German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, Neuherberg, Germany
Zeller, T:
Med Univ Hamburg Eppendorf, Univ Heart & Vasc Ctr Hamburg, Hamburg, Germany
German Ctr Cardiovasc Res, Partner Site Hamburg Lubeck Kiel, Hamburg, Germany
Blankenberg, S:
Med Univ Hamburg Eppendorf, Univ Heart & Vasc Ctr Hamburg, Hamburg, Germany
German Ctr Cardiovasc Res, Partner Site Hamburg Lubeck Kiel, Hamburg, Germany
Anderson, AS:
Univ Dundee, Ctr Publ Hlth Nutr Res, Dundee, Scotland
Tunstall-Pedoe, H:
Univ Dundee, Inst Cardiovasc Res, Dundee, Scotland
Kuulasmaa, K:
Finnish Inst Hlth & Welf, Dept Publ Hlth Solut, Helsinki, Finland
Soderberg, S:
Umea Univ, Dept Publ Hlth & Clin Med, S-90187 Umea, Sweden
Green Published, hybrid, Green Submitted, All Open Access, Hybrid Gold, Green
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