Asthma-COPD overlap is not a homogeneous disorder: further supporting data
Por:
Perez-De-Llano, L, Cosio, BG, Plaza V., Torrego A., Bobolea, Irina
Publicada:
2 nov 2017
Resumen:
Asthma-COPD ovelap (ACO) is an umbrella term that encompasses patients with COPD and eosinophilic inflammation (e-COPD) and smoking asthmatics with non-fully reversible airflow obstruction (SA). We compared the clinical characteristics and the inflammatory profile of e-COPD and SA. Patients classified as e-COPD were older and more often male and showed significantly impaired pulmonary function (likely explained by a heavier smoking habit). On the contrary, SA had more atopic features, more reversibility of airflow obstruction and higher IgE levels. The concentrations of IL-5, IL-13, IL-8, IL-6, TNF-alpha, IL17 in serum were similar between the 2 groups. However, Th2-related biomarkers (periostin, FeNO and blood eosinophils) shower higher median values in e-COPD patients. Our findings reinforce the notion that ACO is a heterogeneous disorder and, as a consequence, it might be unacceptable to offer the same treatment for two related but different conditions.
Filiaciones:
Perez-De-Llano, L:
Hosp Lucus Augusti, Dept Resp Med, Lugo, Spain
Hosp Univ Lucus Augusti, Pneumol Serv, Calle Dr Ulises Romero 1, Lugo 27003, Spain
Cosio, BG:
Hosp Univ Son Espases IdISBa, Dept Resp Med, Palma de Mallorca, Spain
Inst Salud Carlos III, CIBER Enfermedades Resp CIBERES, Madrid, Spain
Plaza V.:
Department of Respiratory Medicine, Hospital de la Santa Creu y Sant Pau, Barcelona, Spain
Institut d'Investigació Biomédica Sant Pau (IIB Sant Pau), Spain
Universitat Autònoma de Barcelona, Department of Medicine, Barcelona, Spain
Torrego A.:
Department of Respiratory Medicine, Hospital de la Santa Creu y Sant Pau, Barcelona, Spain
Institut d'Investigació Biomédica Sant Pau (IIB Sant Pau), Spain
Universitat Autònoma de Barcelona, Department of Medicine, Barcelona, Spain
Bobolea, Irina :
Servei de Pneumologia i Alergia, Hospital Clinic, Barcelona, Spain
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