Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium
Por:
Kong, XZ, Mathias, SR, Guadalupe, T, Glahn, DC, Franke, B, Crivello, F, Tzourio-Mazoyer, N, Fisher, SE, Thompson, PM, Francks, C, Portella M.J., Orhan, Funda
Publicada:
29 may 2018
Resumen:
Hemispheric asymmetry is a cardinal feature of human brain organization. Altered brain asymmetry has also been linked to some cognitive and neuropsychiatric disorders. Here, the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Consortium presents the largest-ever analysis of cerebral cortical asymmetry and its variability across individuals. Cortical thickness and surface area were assessed in MRI scans of 17,141 healthy individuals from 99 datasets worldwide. Results revealed widespread asymmetries at both hemispheric and regional levels, with a generally thicker cortex but smaller surface area in the left hemisphere relative to the right. Regionally, asymmetries of cortical thickness and/or surface area were found in the inferior frontal gyrus, transverse temporal gyrus, parahippocampal gyrus, and entorhinal cortex. These regions are involved in lateralized functions, including language and visuospatial processing. In addition to population-level asymmetries, variability in brain asymmetry was related to sex, age, and intracranial volume. Interestingly, we did not find significant associations between asymmetries and handedness. Finally, with two independent pedigree datasets (n = 1,443 and 1,113, respectively), we found several asymmetries showing significant, replicable heritability. The structural asymmetries identified and their variabilities and heritability provide a reference resource for future studies on the genetic basis of brain asymmetry and altered laterality in cognitive, neurological, and psychiatric disorders.
Filiaciones:
Kong, XZ:
Max Planck Inst Psycholinguist, Language & Genet Dept, NL-6525 XD Nijmegen, Netherlands
Mathias, SR:
Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06511 USA
Guadalupe, T:
Max Planck Inst Psycholinguist, Language & Genet Dept, NL-6525 XD Nijmegen, Netherlands
Glahn, DC:
Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06511 USA
Hartford Hosp, Inst Living, Olin Neuropsychiat Res Ctr, Hartford, CT 06106 USA
Franke, B:
Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Human Genet, NL-6525 GA Nijmegen, Netherlands
Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Psychiat, NL-6525 GA Nijmegen, Netherlands
Crivello, F:
Univ Bordeaux, CNRS, Commissariat Energie Atom & Energies Alternat,UMR, Grp Imagerie Neurofonct,Inst Malad Neurodegenerat, F-33076 Bordeaux, France
Tzourio-Mazoyer, N:
Univ Bordeaux, CNRS, Commissariat Energie Atom & Energies Alternat,UMR, Grp Imagerie Neurofonct,Inst Malad Neurodegenerat, F-33076 Bordeaux, France
Fisher, SE:
Max Planck Inst Psycholinguist, Language & Genet Dept, NL-6525 XD Nijmegen, Netherlands
Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, NL-6525 EN Nijmegen, Netherlands
Thompson, PM:
Univ Southern Calif, Keck Sch Med, Mark & Mary Stevens Neuroimaging & Informat Inst, Imaging Genet Ctr, Marina Del Rey, CA 90292 USA
Francks, C:
Max Planck Inst Psycholinguist, Language & Genet Dept, NL-6525 XD Nijmegen, Netherlands
Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, NL-6525 EN Nijmegen, Netherlands
Portella M.J.:
Biomedical Research Institute Sant Pau, Hospital de la Santa Creu i Sant Pau, Centro de Investigación Biomédica en Red de Salut Mental (CIBERSAM), Barcelona, Catalonia, Spain
Orhan, Funda:
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
Green Submitted, Green Published, Green Accepted, Bronze
|