Mediators of lifestyle intervention effects on neonatal adiposity: are we missing a piece of the puzzle?
Por:
Lima, RA, Desoye, G, Simmons, D, van Poppel, MNM, Corcoy R., Adelantado J.M., Jelsma, Judith G.M.
Publicada:
1 feb 2022
Ahead of Print:
1 mar 2021
Resumen:
We evaluated possible mediators underlying lifestyle intervention effects on neonatal adiposity, assessed with sum of skinfolds and cord blood leptin. This is a secondary analysis of the DALI study, a randomised controlled trial in nine European countries. Pregnant women with a pre-pregnancy body mass index of >= 29 kg/m(2) were randomly assigned to counselling for healthy eating (HE), physical activity (PA), HE&PA combined, or to usual care. We considered five maternal metabolic factors at 24-28 and 35-37 weeks of gestation, and four cord blood factors as possible mediators of the effect of combined HE&PA counselling on neonatal adiposity. From all potential mediators, the intervention only affected cord blood non-esterified fatty acids (NEFA), which was higher in the HE&PA group compared to UC (0.068 (mmol/L), 95% CI: 0.004 to 0.133). Cord blood NEFA did not mediate the HE&PA intervention effects on neonatal sum of skinfolds or cord blood leptin, based on an indirect effect on skinfolds of 0.018 (mm), 95% CI: -0.217 to 0.253 and an indirect effect on leptin of -0.143 (mu g/l), 95% CI: -0.560 to 0.273. The Dali study observed reductions in neonatal adiposity in pregnant women with obesity, but we were not able to identify the underlying metabolic pathway.
Filiaciones:
Lima, RA:
Karl Franzens Univ Graz, Inst Sport Sci, Graz, Austria
Desoye, G:
Med Univ Graz, Dept Obstet & Gynecol, Graz, Austria
Simmons, D:
Western Sydney Univ, Campbelltown, NSW, Australia
Addenbrookes Hosp, Inst Metab Sci, Cambridge, England
van Poppel, MNM:
Karl Franzens Univ Graz, Inst Sport Sci, Graz, Austria
Corcoy R.:
Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
CIBER Bioengineering, Biomaterials and Nanotechnology, Instituto de Salud Carlos III, Madrid, Spain
Adelantado J.M.:
Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
CIBER Bioengineering, Biomaterials and Nanotechnology, Instituto de Salud Carlos III, Madrid, Spain
Jelsma, Judith G.M.:
Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam, Netherlands
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