The role of IL-23 and the IL-23/T(H)17 immune axis in the pathogenesis and treatment of psoriasis
Por:
Girolomoni, G, Strohal, R, Puig, L, Bachelez, H, Barker, J, Boehncke, WH, Prinz, JC
Publicada:
1 oct 2017
Resumen:
Psoriasis is a chronic, immune-mediated disease affecting more than 100 million people worldwide and up to 2.2% of the UK population. The aetiology of psoriasis is thought to originate from an interplay of genetic, environmental, infectious and lifestyle factors. The manner in which genetic and environmental factors interact to contribute to the molecular disease mechanisms has remained elusive. However, the interleukin 23 (IL-23)/T-helper 17 (T(H)17) immune axis has been identified as a major immune pathway in psoriasis disease pathogenesis. Central to this pathway is the cytokine IL-23, a heterodimer composed of a p40 subunit also found in IL-12 and a p19 subunit exclusive to IL-23. IL-23 is important for maintaining T(H)17 responses, and levels of IL-23 are elevated in psoriatic skin compared with non-lesional skin. A number of agents that specifically inhibit IL-23p19 are currently in development for the treatment of moderate-to-severe plaque psoriasis, with recent clinical trials demonstrating efficacy with a good safety and tolerability profile. These data support the role of this cytokine in the pathogenesis of psoriasis. A better understanding of the IL-23/T(H)17 immune axis is vital and will promote the development of additional targets for psoriasis and other inflammatory diseases that share similar genetic aetiology and pathogenetic pathways.
Filiaciones:
Girolomoni, G:
Univ Verona, Dept Med, Sect Dermatol, Verona, Italy
Strohal, R:
Fed Acad Teaching Hosp Feldkirch, Dept Dermatol & Venerol, Feldkirch, Austria
Puig, L:
Univ Autonoma Barcelona, Hosp Santa Creu & Sant Pau, Barcelona, Spain
Bachelez, H:
Univ Paris Diderot, Sorbonne Paris Cite, Paris, France
Hop St Louis, AP HP, Dept Dermatol, Paris, France
Inst Imagine, UMR INSERM U1163, Paris, France
Barker, J:
Kings Coll London, St Johns Inst Dermatol, London, England
Boehncke, WH:
Univ Geneva, Fac Med, Dept Pathol & Immunol, Div Dermatol,Geneva Univ Hosp, Geneva, Switzerland
Prinz, JC:
Univ Munich, Dept Dermatol, Munich, Germany
Green Published, Hybrid Gold
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