Frequency of breast cancer with hereditary risk features in Spain: Analysis from GEICAM "ElA Alamo III" retrospective study
Por:
Marquez-Rodas, I, Pollan, M, Escudero, MJ, Ruiz, A, Martin, M, Santaballa, A, del Prado, PM, Batista, N, Andres, R, Anton, A, Llombart, A, Aramburu, AF, Adrover, E, Gonzalez, S, Segui, MA, Calvo, L, Lizon, J, Lescure, AR, Cajal, TRY, Llort, G, Jara, C, Carrasco, E, Lopez-Tarruella, S
Publicada:
6 oct 2017
Resumen:
Purpose
To determine the frequency of breast cancer (BC) patients with hereditary risk features in a wide retrospective cohort of patients in Spain.
Methods
a retrospective analysis was conducted from 10,638 BC patients diagnosed between 1998 and 2001 in the GEICAM registry "ElA A lamo III", dividing them into four groups according to modified ESMO and SEOM hereditary cancer risk criteria: Sporadic breast cancer group (R0); Individual risk group (IR); Familial risk group (FR); Individual and familial risk group (IFR) with both individual and familial risk criteria.
Results
7,641 patients were evaluable. Of them, 2,252 patients (29.5%) had at least one hereditary risk criteria, being subclassified in: FR 1.105 (14.5%), IR 970 (12.7%), IFR 177 (2.3%). There was a higher frequency of newly diagnosed metastatic patients in the IR group (5.1% vs 3.2%, p = 0.02). In contrast, in RO were lower proportion of big tumors (> T2) (43.8% vs 47.4%, p = 0.023), nodal involvement (43.4% vs 48.1%, p = 0.004) and lower histological grades (20.9% G3 for the R0 vs 29.8%) when compared to patients with any risk criteria.
Conclusions
Almost three out of ten BC patients have at least one hereditary risk cancer feature that would warrant further genetic counseling. Patients with hereditary cancer risk seems to be diagnosed with worse prognosis factors.
Filiaciones:
Marquez-Rodas, I:
Hosp Gen Univ Gregorio Maranon, Serv Oncol Med, Madrid, Spain
Spanish Breast Canc Res Grp GEICAM, San Sebastian Reyes, Spain
Pollan, M:
Spanish Breast Canc Res Grp GEICAM, San Sebastian Reyes, Spain
Inst Salud Carlos III, Madrid, Spain
Escudero, MJ:
Spanish Breast Canc Res Grp GEICAM, San Sebastian Reyes, Spain
Ruiz, A:
Spanish Breast Canc Res Grp GEICAM, San Sebastian Reyes, Spain
Inst Valenciano Oncol, Serv Oncol Med, Valencia, Spain
Martin, M:
Hosp Gen Univ Gregorio Maranon, Serv Oncol Med, Madrid, Spain
Spanish Breast Canc Res Grp GEICAM, San Sebastian Reyes, Spain
Santaballa, A:
Spanish Breast Canc Res Grp GEICAM, San Sebastian Reyes, Spain
Hosp Univ & Politecn La Fe, Serv Oncol Med, Valencia, Spain
del Prado, PM:
Spanish Breast Canc Res Grp GEICAM, San Sebastian Reyes, Spain
Hosp Basurto Osakidetza, Serv Oncol Med, Bilbao, Spain
Batista, N:
Spanish Breast Canc Res Grp GEICAM, San Sebastian Reyes, Spain
Hosp Univ Canarias, Serv Oncol Med, Santa Cruz De Tenerife, Spain
Andres, R:
Spanish Breast Canc Res Grp GEICAM, San Sebastian Reyes, Spain
Hosp Lozano Blesa, Serv Oncol Med, Zaragoza, Spain
Anton, A:
Spanish Breast Canc Res Grp GEICAM, San Sebastian Reyes, Spain
Hosp Univ Miguel Servet, Serv Oncol Med, Zaragoza, Spain
Llombart, A:
Spanish Breast Canc Res Grp GEICAM, San Sebastian Reyes, Spain
Hosp Arnau Vilanova, Serv Oncol Med, Valencia, Spain
Aramburu, AF:
Spanish Breast Canc Res Grp GEICAM, San Sebastian Reyes, Spain
Complejo Univ Albacete, Secc Oncol Med, Albacete, Spain
Adrover, E:
Spanish Breast Canc Res Grp GEICAM, San Sebastian Reyes, Spain
Complejo Univ Albacete, Secc Oncol Med, Albacete, Spain
Gonzalez, S:
Spanish Breast Canc Res Grp GEICAM, San Sebastian Reyes, Spain
Hosp Mutua Terrassa, Serv Oncol Med, Barcelona, Spain
Segui, MA:
Spanish Breast Canc Res Grp GEICAM, San Sebastian Reyes, Spain
Hosp Sabadell Consorcio Sanitario Parc Taul Sabad, Serv Oncol Med, Barcelona, Spain
Calvo, L:
Spanish Breast Canc Res Grp GEICAM, San Sebastian Reyes, Spain
Complejo Hosp Univ A Coruna, Serv Oncol Med, La Coruna, Spain
Lizon, J:
Spanish Breast Canc Res Grp GEICAM, San Sebastian Reyes, Spain
Hosp Univ St Joan, Serv Oncol Med, Alicante, Spain
Lescure, AR:
Spanish Breast Canc Res Grp GEICAM, San Sebastian Reyes, Spain
Hosp Gen Univ Elche, Serv Oncol Med, Elche, Spain
Cajal, TRY:
Spanish Breast Canc Res Grp GEICAM, San Sebastian Reyes, Spain
Hosp Santa Creu & Sant Pau, Serv Oncol Med, Barcelona, Spain
Llort, G:
Spanish Breast Canc Res Grp GEICAM, San Sebastian Reyes, Spain
Inst Oncol Valles, Unitat Consell Genet, Terrassa, Spain
Jara, C:
Spanish Breast Canc Res Grp GEICAM, San Sebastian Reyes, Spain
Hosp Univ Fdn Alcorco, Unidad Oncol, Madrid, Spain
Carrasco, E:
Spanish Breast Canc Res Grp GEICAM, San Sebastian Reyes, Spain
Lopez-Tarruella, S:
Hosp Gen Univ Gregorio Maranon, Serv Oncol Med, Madrid, Spain
Spanish Breast Canc Res Grp GEICAM, San Sebastian Reyes, Spain
Gold, Green Published
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