Gene-environment interaction as a predictor of early adjustment in first episode psychosis
Por:
Fraguas, D, Diaz-Caneja, CM, Corripio, I, Gonzalez-Pinto, A, Lobo, A, Bioque, M, Cuesta, MJ, Sanjuan, J, Rodriguez-Toscano, E, Arias, B, Sarro, S, Cabrera, B, Bulbena, A, Vieta, E, Castro-Fornieles, J, Arango, C, Bernardo, M, Parellada, M
Publicada:
1 nov 2017
Resumen:
Background: This study aims to explore the gene-environment interaction hypothesis applied to pre-symptomatic neurodevelopmental phenotypes of first episode psychosis (FEP), that is, genetic factors might increase vulnerability to the effects of environmental adverse conditions occurring at later stages of development.
Methods: We constructed a schematic 'two-hit' model, with Val/Val homozygosity for the catechol-O-methyltransferase (COMT) Val158Met polymorphism as the 'first hit' and history of obstetric complications and parental socioeconomic status as 'second hits'. Early adjustment, measured using the Premorbid Adjustment Scale, was considered the main outcome. The study population comprised 221 adolescents and adults with FEP and 191 sex-and age-matched controls.
Results: The interaction between the Val/Val COMT genotype and a positive history of obstetric complications plus low parental socioeconomic status was significantly associated with poorer early adjustment. These results were observed both in FEP individuals and in controls, and remained significant after controlling for age, sex, and diagnosis.
Conclusions: Individuals carrying Val/Val seem to be more sensitive to the synergistic effect of environmental factors acting early in neurodevelopment, which leads to vulnerability phenotypes such as impaired early adjustment. (C) 2017 Elsevier B.V. All rights reserved.
Filiaciones:
Fraguas, D:
Univ Complutense, Sch Med, Hosp Gen Univ Gregorio Maranon, Dept Child & Adolescent Psychiat,CIBERSAM,IiSGM, Madrid, Spain
Diaz-Caneja, CM:
Univ Complutense, Sch Med, Hosp Gen Univ Gregorio Maranon, Dept Child & Adolescent Psychiat,CIBERSAM,IiSGM, Madrid, Spain
Corripio, I:
Hosp Santa Creu & Sant Pau, Inst Invest Biomed St Pau IIB St Pau, Dept Psychiat, Barcelona, Spain
UAB, CIBERSAM, Barcelona, Spain
Gonzalez-Pinto, A:
Univ Basque Country, OSI Araba Univ Hosp, BIOARABA Hlth Res Inst, CIBERSAM, Vitoria, Spain
Lobo, A:
Univ Zaragoza, Inst Invest Sanitaria Aragon IIS Aragon, CIBERSAM, Zaragoza, Spain
Bioque, M:
Hosp Clin Barcelona, Neurosci Inst, Barcelona Clin, Schizophrenia Unit,CIBERSAM, Barcelona, Spain
Cuesta, MJ:
Complejo Hosp Navarra, IdiSNA, Dept Psychiat, Pamplona, Spain
Sanjuan, J:
Univ Valencia, INCLIVA, CIBERSAM, Dept Psychiat,Hosp Clin, Valencia, Spain
Rodriguez-Toscano, E:
Univ Complutense, Sch Med, Hosp Gen Univ Gregorio Maranon, Dept Child & Adolescent Psychiat,CIBERSAM,IiSGM, Madrid, Spain
Arias, B:
Univ Barcelona, IBUB, CIBERSAM, Dept Biol Evolutiva Ecol & Ciencies Ambientals,Fa, Barcelona, Spain
Sarro, S:
CIBERSAM, FIDMAG Hermanas Hosp, Barcelona, Spain
Cabrera, B:
Hosp Clin Barcelona, CIBERSAM, Neurosci Inst, Barcelona Clin,Schizophrenia Unit, Barcelona, Spain
Bulbena, A:
Hosp del Mar, Inst Neuropsiquiatria & Addicc, Barcelona, Spain
Hosp del Mar Med Res Inst IMIM, Barcelona, Spain
Autonomous Univ Barcelona UAB, Dept Psychiat & Forens Med, Bellaterra, Spain
Vieta, E:
Univ Barcelona, CIBERSAM, IDIBAPS, Bipolar Disorder Unit,Inst Neurosci,Hosp Clin, Barcelona, Spain
Castro-Fornieles, J:
Univ Barcelona, Dept Psychiat & Clin Psychobiol, Dept Child & Adolescent Psychiat & Psychol,CIBERS, SGR489,Inst Neurosci,Hosp Clin Barcelona,IDIBAPS, Barcelona, Spain
Arango, C:
Univ Complutense, Sch Med, Hosp Gen Univ Gregorio Maranon, Dept Child & Adolescent Psychiat,CIBERSAM,IiSGM, Madrid, Spain
Bernardo, M:
Hosp Clin Barcelona, Neurosci Inst, Barcelona Clin, Schizophrenia Unit, Barcelona, Spain
Univ Barcelona, Dept Med, IDIBAPS, CIBERSAM, Barcelona, Spain
Parellada, M:
Univ Complutense, Sch Med, Hosp Gen Univ Gregorio Maranon, Dept Child & Adolescent Psychiat,CIBERSAM,IiSGM, Madrid, Spain
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