Cerebral amyloid angiopathy in Down syndrome and sporadic and autosomal-dominant Alzheimer's disease
Por:
Carmona-Iragui, M, Balasa, M, Benejam, B, Alcolea, D, Fernandez, S, Videla, L, Sala, I, Sanchez-Saudinos, MB, Morenas-Rodriguez, E, Ribosa-Nogue, R, Illan-Gala, I, Gonzalez-Ortiz, S, Clarimon, J, Schmitt, F, Powell, DK, Bosch, B, Llado, A, Rafii, MS, Head, E, Molinuevo, JL, Blesa, R, Videla, S, Lleo, A, Sanchez-Valle, R, Fortea, J
Publicada:
1 nov 2017
Resumen:
Introduction: We aimed to investigate if cerebral amyloid angiopathy (CAA) is more frequent in genetically determined than in sporadic early-onset forms of Alzheimer's disease (AD) (early-onset AD [EOAD]).
Methods: Neuroimaging features of CAA, apolipoprotein (APOE), and cerebrospinal fluid amyloid beta (A beta) 40 levels were studied in subjects with Down syndrome (DS, n = 117), autosomal-dominant AD (ADAD, n = 29), sporadic EOAD (n 5 42), and healthy controls (n = 68).
Results: CAA was present in 31%, 38%, and 12% of cognitively impaired DS, symptomatic ADAD, and sporadic EOAD subjects and in 13% and 4% of cognitively unimpaired DS individuals and healthy controls, respectively. APOE epsilon 4 genotype was borderline significantly associated with CAA in sporadic EOAD (P = .06) but not with DS or ADAD. There were no differences in A beta 040 levels between groups or between subjects with and without CAA.
Discussion: CAA is more frequently found in genetically determined AD than in sporadic EOAD. Cerebrospinal fluid A beta 40 levels are not a useful biomarker for CAA in AD. (C) 2017 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
Filiaciones:
Carmona-Iragui, M:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu & St Pau, Memory Unit,Dept Neurol, Barcelona, Spain
Fundacio Catalana Sindrome Down, Barcelona Down Med Ctr, Barcelona, Spain
CIBERNED, Ctr Invest Biomed Red Enfermedad Neurodegenerat, Madrid, Spain
Trinity Coll Dublin, Coll Green, Global Brain Hlth Inst, Dublin, Ireland
Balasa, M:
Trinity Coll Dublin, Coll Green, Global Brain Hlth Inst, Dublin, Ireland
Hosp Clin Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Neurol Dept, Alzheimers Dis & Other Cognit Disorders Unit, Barcelona, Spain
Benejam, B:
Fundacio Catalana Sindrome Down, Barcelona Down Med Ctr, Barcelona, Spain
Alcolea, D:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu & St Pau, Memory Unit,Dept Neurol, Barcelona, Spain
CIBERNED, Ctr Invest Biomed Red Enfermedad Neurodegenerat, Madrid, Spain
Fernandez, S:
Fundacio Catalana Sindrome Down, Barcelona Down Med Ctr, Barcelona, Spain
Videla, L:
Fundacio Catalana Sindrome Down, Barcelona Down Med Ctr, Barcelona, Spain
Sala, I:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu & St Pau, Memory Unit,Dept Neurol, Barcelona, Spain
CIBERNED, Ctr Invest Biomed Red Enfermedad Neurodegenerat, Madrid, Spain
Sanchez-Saudinos, MB:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu & St Pau, Memory Unit,Dept Neurol, Barcelona, Spain
CIBERNED, Ctr Invest Biomed Red Enfermedad Neurodegenerat, Madrid, Spain
Morenas-Rodriguez, E:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu & St Pau, Memory Unit,Dept Neurol, Barcelona, Spain
CIBERNED, Ctr Invest Biomed Red Enfermedad Neurodegenerat, Madrid, Spain
Ribosa-Nogue, R:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu & St Pau, Memory Unit,Dept Neurol, Barcelona, Spain
CIBERNED, Ctr Invest Biomed Red Enfermedad Neurodegenerat, Madrid, Spain
Illan-Gala, I:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu & St Pau, Memory Unit,Dept Neurol, Barcelona, Spain
CIBERNED, Ctr Invest Biomed Red Enfermedad Neurodegenerat, Madrid, Spain
Gonzalez-Ortiz, S:
Univ Autonoma Barcelona, Hosp Mar, Dept Radiol, Barcelona, Spain
Clarimon, J:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu & St Pau, Memory Unit,Dept Neurol, Barcelona, Spain
CIBERNED, Ctr Invest Biomed Red Enfermedad Neurodegenerat, Madrid, Spain
Schmitt, F:
Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40536 USA
Powell, DK:
Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40536 USA
Bosch, B:
CIBERNED, Ctr Invest Biomed Red Enfermedad Neurodegenerat, Madrid, Spain
Llado, A:
Hosp Clin Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Neurol Dept, Alzheimers Dis & Other Cognit Disorders Unit, Barcelona, Spain
Rafii, MS:
Univ Calif San Diego, Dept Neurosci, Adult Syndrome Clin, San Diego, CA 92103 USA
Univ Southern Calif, Alzheimers Therapeut Res Inst, San Diego, CA USA
Head, E:
Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40536 USA
Molinuevo, JL:
Hosp Clin Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Neurol Dept, Alzheimers Dis & Other Cognit Disorders Unit, Barcelona, Spain
Univ Pompeu Fabra, Fundacio Pasqual Maragall, BarcelonaBeta Brain Res Ctr, Barcelona, Spain
Blesa, R:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu & St Pau, Memory Unit,Dept Neurol, Barcelona, Spain
CIBERNED, Ctr Invest Biomed Red Enfermedad Neurodegenerat, Madrid, Spain
Videla, S:
Fundacio Catalana Sindrome Down, Barcelona Down Med Ctr, Barcelona, Spain
Univ Pompeu Fabra, Dept Expt & Hlth Sci, Fac Hlth & Life Sci, Barcelona, Spain
Lleo, A:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu & St Pau, Memory Unit,Dept Neurol, Barcelona, Spain
CIBERNED, Ctr Invest Biomed Red Enfermedad Neurodegenerat, Madrid, Spain
Sanchez-Valle, R:
Hosp Clin Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Neurol Dept, Alzheimers Dis & Other Cognit Disorders Unit, Barcelona, Spain
Fortea, J:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu & St Pau, Memory Unit,Dept Neurol, Barcelona, Spain
Fundacio Catalana Sindrome Down, Barcelona Down Med Ctr, Barcelona, Spain
CIBERNED, Ctr Invest Biomed Red Enfermedad Neurodegenerat, Madrid, Spain
Green Accepted, Green Published
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