Altered amplitude of low frequency fluctuations in schizophrenia patients with persistent auditory verbal hallucinations
Por:
Alonso-Solis, A, Vives-Gilabert, Y, Portella, MJ, Rabella, M, Grasa, EM, Roldan, A, Keymer-Gausset, A, Molins, C, Nunez-Marin, F, Gomez-Anson, B, Alvarez, E, Corripio, I
Publicada:
1 nov 2017
Resumen:
The aim of this study is to analyze the differences in low frequency fluctuation (LFF) values between schizophrenia patients with and without auditory verbal hallucinations (AVH). Nineteen schizophrenia patients with persistent AVH (HP), fourteen non-hallucinating schizophrenia patients (nHP) and twenty healthy controls (HC) underwent R-fMRI. LFF values were calculated in the slow frequency band (0.01-0.08 Hz). By means of group level contrasts, we performed direct voxel-wise group comparisons. Both groups of patients showed decreased amplitude LFF (ALFF) values in the occipital pole and lingual gyrus compared to HC, whereas increased ALFF values were found in the temporal pole and fusifom gyrus. Schizophrenia patients exhibited decreased fractional ALFF (fALFF) values in the precuneus, occipital pole and bilateral occipital cortex, and increased fALFF in the insula compared to HC. There were also differences between patients with and without AVH. (Ok to start with lower case?) fALFF values were higher in the putamen and insular cortex and lower in the frontal pole in HP compared to nHP and HC. ALFF increased in HP patients in the bilateral thalamus and bilateral parahippocampal gyrus, compared to nHP patients and HC. Our results suggest that altered dynamics in low-frequency fluctuations may play a key role in the neurophysiology of auditory hallucinations. (C) 2017 Elsevier B.V. All rights reserved.
Filiaciones:
Alonso-Solis, A:
UAB, Santa Creu & St Pau Hosp, Biomed Res Inst St Pau IIB ST PAU, Dept Psychiat, Barcelona, Spain
CIBERSAM, Mental Hlth Networking Biomed Res Ctr, Barcelona, Spain
Vives-Gilabert, Y:
UAB, High Energy Phys Inst IFAE, Sci Informat Port PIC, Barcelona, Spain
Portella, MJ:
UAB, Santa Creu & St Pau Hosp, Biomed Res Inst St Pau IIB ST PAU, Dept Psychiat, Barcelona, Spain
CIBERSAM, Mental Hlth Networking Biomed Res Ctr, Barcelona, Spain
Rabella, M:
UAB, Santa Creu & St Pau Hosp, Biomed Res Inst St Pau IIB ST PAU, Dept Psychiat, Barcelona, Spain
Grasa, EM:
UAB, Santa Creu & St Pau Hosp, Biomed Res Inst St Pau IIB ST PAU, Dept Psychiat, Barcelona, Spain
CIBERSAM, Mental Hlth Networking Biomed Res Ctr, Barcelona, Spain
Roldan, A:
UAB, Santa Creu & St Pau Hosp, Biomed Res Inst St Pau IIB ST PAU, Dept Psychiat, Barcelona, Spain
Keymer-Gausset, A:
UAB, Santa Creu & St Pau Hosp, Biomed Res Inst St Pau IIB ST PAU, Dept Psychiat, Barcelona, Spain
Molins, C:
UAB, Santa Creu & St Pau Hosp, Biomed Res Inst St Pau IIB ST PAU, Dept Psychiat, Barcelona, Spain
Nunez-Marin, F:
UAB, Santa Creu & St Pau Hosp, Dept Neuroradiol, Barcelona, Spain
Gomez-Anson, B:
UAB, Santa Creu & St Pau Hosp, Dept Neuroradiol, Barcelona, Spain
Alvarez, E:
UAB, Santa Creu & St Pau Hosp, Biomed Res Inst St Pau IIB ST PAU, Dept Psychiat, Barcelona, Spain
CIBERSAM, Mental Hlth Networking Biomed Res Ctr, Barcelona, Spain
Corripio, I:
UAB, Santa Creu & St Pau Hosp, Biomed Res Inst St Pau IIB ST PAU, Dept Psychiat, Barcelona, Spain
CIBERSAM, Mental Hlth Networking Biomed Res Ctr, Barcelona, Spain
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