Anti-NF155 chronic inflammatory demyelinating polyradiculoneuropathy strongly associates to HLA-DRB15
Por:
Martinez-Martinez, L, Lleixa, MC, Boera-Carnicero, G, Cortese, A, Devaux, J, Siles, A, Rajabally, Y, Martinez-Pineiro, A, Carvajal, A, Pardo, J, Delmont, E, Attarian, S, Diaz-Manera, J, Callegari, I, Marchioni, E, Franciotta, D, Benedetti, L, Lauria, G, Martin, ODL, Juarez, C, Illa, I, Querol, L
Publicada:
16 nov 2017
Resumen:
Background: The aim of the research is to study the human leukocyte antigen (HLA) class II allele frequencies in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) associated with anti-neurofascin 155 (NF155) antibodies.
Methods: Thirteen anti-NF155+ and 35 anti-NF155 negative (anti-NF155neg) CIDP patients were included in a case-control study. The frequencies of the DRB1 HLA allele were analyzed in all patients while DQ frequencies were only studied in patients sharing the DRB1*15 allele. In silico HLA-peptide binding and NF155 antigenicity, predictions were performed to analyze overlap between presented peptides and antigenic regions.
Results: DRB1*15 alleles (DRB1*15: 01 and DRB1*15: 02) were present in 10 out of 13 anti-NF155+ CIDP patients and in only 5 out of 35 anti-NF155neg CIDP patients (77 vs 14%; OR = 20, CI = 4.035 to 99.13). DRB1*15 alleles appeared also in significantly higher proportions in anti-NF155+ CIDP than in normal population (77 vs 17%; OR = 16.9, CI = 4.434 to 57. 30). Seven anti-NF155+ CIDP patients (53%) and 5 anti-NF155neg CIDP patients had the DRB1*15: 01 allele (OR = 7, p = 0.009), while 3 anti-NF155+ CIDP patients and none of the anti-NF155neg CIDP patients had the DRB1*15: 02 allele (OR = 23.6, p = 0.016). In silico analysis of the NF155 peptides binding to DRB1*15 alleles showed significant overlap in the peptides presented by the 15: 01 and 15: 02 alleles, suggesting functional homology.
Conclusions: DRB1*15 alleles are the first strong risk factor associated to a CIDP subset, providing additional evidence that anti-NF155+ CIDP patients constitute a differentiated disease within the CIDP syndrome.
Filiaciones:
Martinez-Martinez, L:
Univ Autonoma Barcelona, Immunol Dept, Hosp Santa Creu & St Pau, Barcelona, Spain
Lleixa, MC:
Univ Autonoma Barcelona, Neuromuscular Dis Unit, Hosp Santa Creu & St Pau, Dept Neurol, Mas Casanovas 90, Barcelona 08041, Spain
CIBERER, Madrid, Spain
Boera-Carnicero, G:
Univ Autonoma Barcelona, Immunol Dept, Hosp Santa Creu & St Pau, Barcelona, Spain
Cortese, A:
IRCCS Fdn C Mondino Natl Neurol Inst, Pavia, Italy
UCL Inst Neurol, Natl Hosp Neurol & Neurosurg, MRC Ctr Neuromuscular Dis, Queen Sq, London, England
Devaux, J:
Aix Marseille Univ, CNRS, CRN2M, UMR 7286, Marseille, France
Siles, A:
Univ Autonoma Barcelona, Neuromuscular Dis Unit, Hosp Santa Creu & St Pau, Dept Neurol, Mas Casanovas 90, Barcelona 08041, Spain
CIBERER, Madrid, Spain
Rajabally, Y:
Univ Hosp Birmingham, Queen Elizabeth Hosp, Reg Neuromuscular Clin, Birmingham, W Midlands, England
Martinez-Pineiro, A:
Univ Autonoma Barcelona, Neurol Dept, Hosp Germans Trias & Pujol, Badalona, Spain
Carvajal, A:
Hosp Virgen de las Nieves, Dept Neurol, Granada, Spain
Pardo, J:
Hosp Clin Santiago, Dept Neurol, Santiago De Compostela, Spain
Delmont, E:
Aix Marseille Univ, CNRS, CRN2M, UMR 7286, Marseille, France
Aix Marseille Univ, Timone Univ Hosp, Referral Ctr ALS & Neuromuscular Dis, Marseille, France
Attarian, S:
Aix Marseille Univ, Timone Univ Hosp, Referral Ctr ALS & Neuromuscular Dis, Marseille, France
Diaz-Manera, J:
Univ Autonoma Barcelona, Neuromuscular Dis Unit, Hosp Santa Creu & St Pau, Dept Neurol, Mas Casanovas 90, Barcelona 08041, Spain
CIBERER, Madrid, Spain
Callegari, I:
IRCCS Fdn C Mondino Natl Neurol Inst, Pavia, Italy
Univ Pavia, Monza Policlin & Pavia Mondino, Neurosci Consortium, Pavia, Italy
Marchioni, E:
IRCCS Fdn C Mondino Natl Neurol Inst, Pavia, Italy
Franciotta, D:
IRCCS Fdn C Mondino Natl Neurol Inst, Pavia, Italy
Benedetti, L:
Univ Genoa, Dept Neurosci Rehabil Ophthalmol Genet Maternal &, Genoa, Italy
IRCCS AOU San Martino IST, Genoa, Italy
Lauria, G:
IRCCS Fdn Carlo Besta Neurol Inst, Neuroalgol Unit, Milan, Italy
Univ Milan, Dept Biomed & Clin Sci Luigi Sacco, Milan, Italy
Martin, ODL:
Univ Autonoma Barcelona, Immunol Dept, Hosp Santa Creu & St Pau, Barcelona, Spain
Juarez, C:
Univ Autonoma Barcelona, Immunol Dept, Hosp Santa Creu & St Pau, Barcelona, Spain
Illa, I:
Univ Autonoma Barcelona, Neuromuscular Dis Unit, Hosp Santa Creu & St Pau, Dept Neurol, Mas Casanovas 90, Barcelona 08041, Spain
CIBERER, Madrid, Spain
Querol, L:
Univ Autonoma Barcelona, Neuromuscular Dis Unit, Hosp Santa Creu & St Pau, Dept Neurol, Mas Casanovas 90, Barcelona 08041, Spain
CIBERER, Madrid, Spain
Gold, Green Published
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