Spread of a SARS-CoV-2 variant through Europe in the summer of 2020
Por:
Hodcroft, EB, Zuber, M, Nadeau, S, Vaughan, TG, Crawford, KHD, Althaus, CL, Reichmuth, ML, Bowen, JE, Walls, AC, Corti, D, Bloom, JD, Veesler, D, Mateo, D, Hernando, A, Comas, I, Candelas, FG, Stadler, T, Neher, RA, Rabella N., Navarro F., Miró E., Fernandez-Cadenas I, Parra Grande, Monica
Publicada:
29 jul 2021
Ahead of Print:
1 jun 2021
Resumen:
Following its emergence in late 2019, the spread of SARS-CoV-21,2 has been tracked by phylogenetic analysis of viral genome sequences in unprecedented detail(3-5). Although the virus spread globally in early 2020 before borders closed, intercontinental travel has since been greatly reduced. However, travel within Europe resumed in the summer of 2020. Here we report on a SARS-CoV-2 variant, 20E (EU1), that was identified in Spain in early summer 2020 and subsequently spread across Europe. We find no evidence that this variant has increased transmissibility, but instead demonstrate how rising incidence in Spain, resumption of travel, and lack of effective screening and containment may explain the variant's success. Despite travel restrictions, we estimate that 20E (EU1) was introduced hundreds of times to European countries by summertime travellers, which is likely to have undermined local efforts to minimize infection with SARS-CoV-2. Our results illustrate how a variant can rapidly become dominant even in the absence of a substantial transmission advantage in favourable epidemiological settings. Genomic surveillance is critical for understanding how travel can affect transmission of SARS-CoV-2, and thus for informing future containment strategies as travel resumes.
Filiaciones:
Hodcroft, EB:
Univ Basel, Biozentrum, Basel, Switzerland
Swiss Inst Bioinformat, Basel, Switzerland
Univ Bern, Inst Social & Prevent Med, Bern, Switzerland
Zuber, M:
Univ Basel, Biozentrum, Basel, Switzerland
Nadeau, S:
Swiss Inst Bioinformat, Basel, Switzerland
Swiss Fed Inst Technol, Dept Biosyst Sci & Engn, Basel, Switzerland
Vaughan, TG:
Swiss Inst Bioinformat, Basel, Switzerland
Swiss Fed Inst Technol, Dept Biosyst Sci & Engn, Basel, Switzerland
Crawford, KHD:
Fred Hutchinson Canc Res Ctr, Div Basic Sci & Computat Biol Program, Seattle, WA USA
Univ Washington, Dept Genome Sci, Seattle, WA USA
Univ Washington, Med Scientist Training Program, Seattle, WA USA
Althaus, CL:
Univ Bern, Inst Social & Prevent Med, Bern, Switzerland
Reichmuth, ML:
Univ Bern, Inst Social & Prevent Med, Bern, Switzerland
Bowen, JE:
Univ Washington, Dept Biochem, Seattle, WA 98195 USA
Walls, AC:
Univ Washington, Dept Biochem, Seattle, WA 98195 USA
Corti, D:
Humabs Biomed SA, Bellinzona, Switzerland
Bloom, JD:
Fred Hutchinson Canc Res Ctr, Div Basic Sci & Computat Biol Program, Seattle, WA USA
Univ Washington, Dept Genome Sci, Seattle, WA USA
Howard Hughes Med Inst, Seattle, WA USA
Veesler, D:
Univ Washington, Dept Biochem, Seattle, WA 98195 USA
Mateo, D:
Kido Dynam SA, Lausanne, Switzerland
Hernando, A:
Kido Dynam SA, Lausanne, Switzerland
Comas, I:
Biomed Inst Valencia IBV CSIC, TB Genom Unit, Valencia, Spain
CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain
Candelas, FG:
CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain
Univ Valencia, Joint Res Unit Infect & Publ Hlth FISABIO, Inst Integrat Syst BioL 12SysBio, Valencia, Spain
Stadler, T:
Swiss Inst Bioinformat, Basel, Switzerland
Swiss Fed Inst Technol, Dept Biosyst Sci & Engn, Basel, Switzerland
Neher, RA:
Univ Basel, Biozentrum, Basel, Switzerland
Swiss Inst Bioinformat, Basel, Switzerland
Rabella N.:
CREPIMC, Institut d’Investigació Biomèdica Sant Pau, Barcelona, Spain
Servei de Microbiologia, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Navarro F.:
CREPIMC, Institut d’Investigació Biomèdica Sant Pau, Barcelona, Spain
Servei de Microbiologia, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Miró E.:
CREPIMC, Institut d’Investigació Biomèdica Sant Pau, Barcelona, Spain
Servei de Microbiologia, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Fernandez-Cadenas I:
Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain
Parra Grande, Monica:
Laboratorio de Microbiología, Hospital Marina Baixa, Villajoyosa, Spain
Bronze, Green Published
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