Advanced Quantitative Lipoprotein Characteristics Do Not Relate to Healthy Dietary Patterns in Adults from a Mediterranean Area
Por:
Rojo-Lopez, MI, Castelblanco, E, Real, J, Hernandez, M, Falguera, M, Amigo, N, Julve, J, Alonso, N, Franch-Nadal, J, Granado-Casas, M, Mauricio, D
Publicada:
1 dic 2021
Resumen:
We aimed to assess the potential relationship between dietary patterns (i.e., Mediterranean diet and healthy eating) and the advanced lipoprotein profile (ALP) in a representative cohort of the Mediterranean population. Thus, ALP data from 1142 participants, including 222 with type 1 (19.4%) and 252 type 2 diabetes (22.1%), and 668 subjects without diabetes were used to study cross-sectional associations between quantitative characteristics of lipoproteins and adherence to the Mediterranean diet. The alternate Mediterranean diet score (aMED) and the alternate healthy eating index (aHEI) were calculated. The ALP was determined by nuclear magnetic resonance (NMR) spectrometry. Bivariable and multivariable analyses were performed. Participants in the third tertile of the aMED showed higher levels of low-density lipoprotein triglycerides (LDL-TG) (mean (SD) 17.5 (5.0); p = 0.037), large high-density lipoprotein particles (HDL-P) (0.3 (0.1); p = 0.037), and medium low-density lipoprotein particles (LDL-P) (434.0 (143.0); p = 0.037). In comparison with participants in the second and first tertiles of the aHEI, participants in the third tertile had higher levels of LDL-TG (17.7 (5.0); p = 0.010), and large HDL-P (0.3 (0.1); p = 0.002), IDL-C (11.8 (5.0); p = 0.001), intermediate-density lipoprotein triglycerides (IDL-TG) (13.2 (4.2); p < 0.001), LDL-TG (17.7(5.0); p = 0.010), high-density lipoprotein triglycerides (HDL-TG) (14.5 (4.4); p = 0.029,) large HDL-P (0.3 (0.1); p = 0.002) and very-low-density lipoprotein particles (VLDL-P) size (42.1 (0.2); p = 0.011). The adjusted-multivariable analysis for potential confounding variables did not show any association between the lipoproteins and dietary patterns (i.e., aMED and aHEI). In conclusion, none of the quantitative characteristics of lipoproteins were concomitantly associated with the extent of adherence to the Mediterranean diet measured using the aMED or aHEI scores in the studied population. Our findings also revealed that people with the highest adherence were older, had a higher body mass index (BMI) and more frequently had dyslipidemia, hypertension, or diabetes than those with the lowest adherence to the Mediterranean diet (MDiet). Thus, further research may be needed to assess the potential role of the dietary pattern on the ALP.
Filiaciones:
Rojo-Lopez, MI:
Hosp Santa Cruz & San Pau, Dept Endocrinol & Nutr, Barcelona 08041, Spain
Inst Invest Biomed Sant Pau IIB St Pau, Barcelona 08041, Spain
Castelblanco, E:
Washington Univ, Endocrinol Metab & Lipid Res Div, Dept Internal Med, Sch Med, St Louis, MO 63110 USA
Real, J:
Inst Salud Carlos III, Ctr Biomed Res Diabet & Associated Metab Dis CIBE, Madrid 28029, Spain
Inst Univ Invest Atencio Primaria Jordi Gol, Unitat Suport Recerca Barcelona, DAP Cat Grp, Barcelona 08041, Spain
Hernandez, M:
Univ Hosp Arnau Vilanova, Dept Endocrinol & Nutr, Lleida 25198, Spain
Univ Lleida, Lleida Inst Biomed Res Dr Pifarre Fdn IRBLleida, Lleida 25198, Spain
Falguera, M:
Univ Lleida, Lleida Inst Biomed Res Dr Pifarre Fdn IRBLleida, Lleida 25198, Spain
Inst Catala Salut, Primary Hlth Care Ctr Cervera, Gerencia Atencio Primaria, Lleida 25200, Spain
Amigo, N:
Inst Salud Carlos III, Ctr Biomed Res Diabet & Associated Metab Dis CIBE, Madrid 28029, Spain
Univ RoviraiVirgili, Dept Basic Med Sci, IISPV, Tarragona 43007, Spain
Biosfer Teslab SL, Reus 43204, Spain
Julve, J:
Hosp Santa Cruz & San Pau, Dept Endocrinol & Nutr, Barcelona 08041, Spain
Inst Invest Biomed Sant Pau IIB St Pau, Barcelona 08041, Spain
Inst Salud Carlos III, Ctr Biomed Res Diabet & Associated Metab Dis CIBE, Madrid 28029, Spain
Univ Autonoma Barcelona, Dept Biochem & Mol Biol, Barcelona 08041, Spain
Alonso, N:
Inst Salud Carlos III, Ctr Biomed Res Diabet & Associated Metab Dis CIBE, Madrid 28029, Spain
Hosp Badalona Germans Trias & Pujol, Endocrinol & Nutr Dept, Badalona 08916, Spain
Univ Autonoma Barcelona, Dept Med, Barcelona 08041, Spain
Franch-Nadal, J:
Inst Salud Carlos III, Ctr Biomed Res Diabet & Associated Metab Dis CIBE, Madrid 28029, Spain
Inst Univ Invest Atencio Primaria Jordi Gol, Unitat Suport Recerca Barcelona, DAP Cat Grp, Barcelona 08041, Spain
InstitutCatala Salut, Gerencia Atencio Primaria Barcelona, Primary Hlth Care Ctr Raval Sud, Barcelona 08001, Spain
Granado-Casas, M:
Hosp Santa Cruz & San Pau, Dept Endocrinol & Nutr, Barcelona 08041, Spain
Inst Invest Biomed Sant Pau IIB St Pau, Barcelona 08041, Spain
Inst Salud Carlos III, Ctr Biomed Res Diabet & Associated Metab Dis CIBE, Madrid 28029, Spain
Inst Univ Invest Atencio Primaria Jordi Gol, Unitat Suport Recerca Barcelona, DAP Cat Grp, Barcelona 08041, Spain
Univ Lleida, Lleida Inst Biomed Res Dr Pifarre Fdn IRBLleida, Lleida 25198, Spain
Mauricio, D:
Hosp Santa Cruz & San Pau, Dept Endocrinol & Nutr, Barcelona 08041, Spain
Inst Invest Biomed Sant Pau IIB St Pau, Barcelona 08041, Spain
Inst Salud Carlos III, Ctr Biomed Res Diabet & Associated Metab Dis CIBE, Madrid 28029, Spain
Inst Univ Invest Atencio Primaria Jordi Gol, Unitat Suport Recerca Barcelona, DAP Cat Grp, Barcelona 08041, Spain
Univ Vic UVIC UCC, Fac Med, Vic 08500, Spain
Green Published, gold
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