Characteristics of subjective cognitive decline associated with amyloid positivity
Por:
Janssen, O, Jansen, WJ, Vos, SJB, Boada, M, Parnetti, L, Gabryelewicz, T, Fladby, T, Molinuevo, JL, Villeneuve, S, Hort, J, Epelbaum, S, Lleo, A, Engelborghs, S, van der Flier, WM, Landau, S, Popp, J, Wallin, A, Scheltens, P, Rikkert, MO, Snyder, PJ, Rowe, C, Chetelat, G, Ruiz, A, Marquie, M, Chipi, E, Wolfsgruber, S, Heneka, M, Boecker, H, Peters, O, Jarholm, J, Rami, L, Tort-Merino, A, Binette, AP, Poirier, J, Rosa-Neto, P, Cerman, J, Dubois, B, Teichmann, M, Alcolea, D, Fortea, J, Sanchez-Saudinos, MB, Ebenau, J, Pocnet, C, Eckerstrom, M, Thompson, L, Villemagne, V, Buckley, R, Burnham, S, Delarue, M, Freund-Levi, Y, Wallin, AK, Ramakers, I, Tsolaki, M, Soininen, H, Hampel, H, Spiru, L, Tijms, B, Ossenkoppele, R, Verhey, FRJ, Jessen, F, Visser, PJ
Publicada:
1 oct 2022
Ahead of Print:
1 dic 2021
Resumen:
Introduction The evidence for characteristics of persons with subjective cognitive decline (SCD) associated with amyloid positivity is limited. Methods In 1640 persons with SCD from 20 Amyloid Biomarker Study cohort, we investigated the associations of SCD-specific characteristics (informant confirmation, domain-specific complaints, concerns, feelings of worse performance) demographics, setting, apolipoprotein E gene (APOE) epsilon 4 carriership, and neuropsychiatric symptoms with amyloid positivity. Results Between cohorts, amyloid positivity in 70-year-olds varied from 10% to 76%. Only older age, clinical setting, and APOE epsilon 4 carriership showed univariate associations with increased amyloid positivity. After adjusting for these, lower education was also associated with increased amyloid positivity. Only within a research setting, informant-confirmed complaints, memory complaints, attention/concentration complaints, and no depressive symptoms were associated with increased amyloid positivity. Feelings of worse performance were associated with less amyloid positivity at younger ages and more at older ages. Discussion Next to age, setting, and APOE epsilon 4 carriership, SCD-specific characteristics may facilitate the identification of amyloid-positive individuals.
Filiaciones:
Janssen, O:
Maastricht Univ, Alzheimer Ctr Limburg, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, POB 616, NL-6200 MD Maastricht, Netherlands
Jansen, WJ:
Maastricht Univ, Alzheimer Ctr Limburg, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, POB 616, NL-6200 MD Maastricht, Netherlands
Vos, SJB:
Maastricht Univ, Alzheimer Ctr Limburg, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, POB 616, NL-6200 MD Maastricht, Netherlands
Boada, M:
Univ Int Catalunya Barcelona, Fac Med, Inst Catala Neurociencies Aplicades, Fundacio ACE, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Parnetti, L:
Univ Perugia, Ctr Memory Disturbances, Dept Med & Surg, Sect Neurol,Lab Clin Neurochem, Perugia, Italy
Gabryelewicz, T:
Polish Acad Sci, Mossakowski Med Res Ctr, Dept Neurodegenerat Disorders, Warsaw, Poland
Fladby, T:
Akershus Univ Hosp, Dept Neurol, Lorenskog, Norway
Molinuevo, JL:
Hosp Clin Barcelona, August Pi & Sunyer Biomed Res Inst IDIBAPS, Neurol Serv, Alzheimers Dis & Other Cognit Disorders Unit, Barcelona, Spain
Villeneuve, S:
Ctr Studies Prevent Alzheimers Dis StOP AD Ctr, Montreal, PQ, Canada
Hort, J:
Charles Univ Prague, Fac Med 2, Dept Neurol, Prague, Czech Republic
Motol Univ Hosp, Prague, Czech Republic
St Annes Univ Hosp, Int Clin Res Ctr, Brno, Czech Republic
Epelbaum, S:
Hop Pitie Salpetiere, AP HP, Ctr Excellence Neurodegenerat Dis CoEN, Inst Memory & Alzheimers Dis IM2A,Dept Neurol, Paris, France
Sorbonne Univ, Aramis Project Team, INRIA, Paris Brain Inst,Inst Cerveau ICM,INSERM, Paris, France
Lleo, A:
Hosp Santa Creu & Sant Pau, Neurol Dept, Barcelona, Spain
Engelborghs, S:
Vrije Univ Brussel, VUB Brussels, Brussels, Belgium
Univ Antwerp, Antwerp, Belgium
van der Flier, WM:
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Amsterdam UMC,Amsterdam Neurosci, Amsterdam, Netherlands
Landau, S:
Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA
Popp, J:
Univ Hosp Zurich, Dept Geriatr Psychiat Psychiat, Zurich, Switzerland
Univ Hosp Lausanne, Old Age Psychiat, Lausanne, Switzerland
Wallin, A:
CSIRO Hlth & Biosecur, Parkville, Vic, Australia
Lund Univ, Dept Clin Sci Malmo, Clin Memory Res Unit, Lund, Sweden
Univ Gothenburg, Inst Neurosci & Physiol, Sahlgrenska Acad, Molndal, Sweden
Scheltens, P:
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Amsterdam UMC,Amsterdam Neurosci, Amsterdam, Netherlands
Rikkert, MO:
Radboud Univ Nijmegen, Radboud Alzheimer Ctr, Dept Geriatr Med, Med Ctr, Nijmegen, Netherlands
Snyder, PJ:
Univ Oslo, Inst Clin Med, Oslo, Norway
Univ Rhode Isl, Kingston, RI 02881 USA
Rowe, C:
Austin Hlth, Dept Mol Imaging & Therapy, Melbourne, Vic, Australia
Chetelat, G:
INSERM, Inst Natl St & Rech Mdicale, Caen, France
Ruiz, A:
Univ Int Catalunya Barcelona, Fac Med, Inst Catala Neurociencies Aplicades, Fundacio ACE, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Marquie, M:
Univ Int Catalunya Barcelona, Fac Med, Inst Catala Neurociencies Aplicades, Fundacio ACE, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Chipi, E:
Univ Perugia, Ctr Memory Disturbances, Dept Med & Surg, Sect Neurol,Lab Clin Neurochem, Perugia, Italy
Wolfsgruber, S:
Deutsch Zentrum Neurodegenerat Erkrankungen eV DZ, German Ctr Neurodegenerat Dis Clin Res, Zentrum Klin Forsch AG, Cologne, Germany
Univ Hosp Bonn, Dept Neurodegenerat Dis & Psychiat, Bonn, Germany
Heneka, M:
Univ Hosp Bonn, Dept Neurodegenerat Dis & Psychiat, Bonn, Germany
Boecker, H:
Univ Hosp Bonn, Dept Radiol, Funct Neuroimaging Grp, Bonn, Germany
Peters, O:
Charite Univ Med Berlin CBF, Klin Psychiat & Psychotherapie, Berlin, Germany
Jarholm, J:
Akershus Univ Hosp, Dept Neurol, Lorenskog, Norway
Rami, L:
Hosp Clin Barcelona, August Pi & Sunyer Biomed Res Inst IDIBAPS, Neurol Serv, Alzheimers Dis & Other Cognit Disorders Unit, Barcelona, Spain
Tort-Merino, A:
Hosp Clin Barcelona, August Pi & Sunyer Biomed Res Inst IDIBAPS, Neurol Serv, Alzheimers Dis & Other Cognit Disorders Unit, Barcelona, Spain
Binette, AP:
Ctr Studies Prevent Alzheimers Dis StOP AD Ctr, Montreal, PQ, Canada
Poirier, J:
Ctr Studies Prevent Alzheimers Dis StOP AD Ctr, Montreal, PQ, Canada
Rosa-Neto, P:
Ctr Studies Prevent Alzheimers Dis StOP AD Ctr, Montreal, PQ, Canada
Cerman, J:
Charles Univ Prague, Fac Med 2, Dept Neurol, Prague, Czech Republic
Motol Univ Hosp, Prague, Czech Republic
St Annes Univ Hosp, Int Clin Res Ctr, Brno, Czech Republic
Dubois, B:
Hop Pitie Salpetiere, AP HP, Ctr Excellence Neurodegenerat Dis CoEN, Inst Memory & Alzheimers Dis IM2A,Dept Neurol, Paris, France
Teichmann, M:
Hop Pitie Salpetiere, AP HP, Ctr Excellence Neurodegenerat Dis CoEN, Inst Memory & Alzheimers Dis IM2A,Dept Neurol, Paris, France
Alcolea, D:
Hosp Santa Creu & Sant Pau, Neurol Dept, Barcelona, Spain
Fortea, J:
Hosp Santa Creu & Sant Pau, Neurol Dept, Barcelona, Spain
Sanchez-Saudinos, MB:
Hosp Santa Creu & Sant Pau, Neurol Dept, Barcelona, Spain
Ebenau, J:
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Amsterdam UMC,Amsterdam Neurosci, Amsterdam, Netherlands
Pocnet, C:
Univ Hosp Lausanne, Old Age Psychiat, Lausanne, Switzerland
Eckerstrom, M:
Univ Gothenburg, Inst Neurosci & Physiol, Sahlgrenska Acad, Molndal, Sweden
Thompson, L:
Univ Oslo, Inst Clin Med, Oslo, Norway
Univ Rhode Isl, Kingston, RI 02881 USA
Villemagne, V:
Austin Hlth, Dept Mol Imaging & Therapy, Melbourne, Vic, Australia
Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA
Buckley, R:
Harvard Med Sch, Brigham & Womens Hosp, Boston, MA 02115 USA
Harvard Med Sch, Dept Neurol, Massachusetts Gen Hosp, Boston, MA 02115 USA
Burnham, S:
Univ Perugia, Ctr Memory Disturbances, Dept Med & Surg, Sect Neurol,Lab Clin Neurochem, Perugia, Italy
Delarue, M:
INSERM, Inst Natl St & Rech Mdicale, Caen, France
Freund-Levi, Y:
Karolinska Inst, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden
Wallin, AK:
Lund Univ, Dept Clin Sci Malmo, Clin Memory Res Unit, Lund, Sweden
Ramakers, I:
Maastricht Univ, Alzheimer Ctr Limburg, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, POB 616, NL-6200 MD Maastricht, Netherlands
Tsolaki, M:
Aristotle Univ Thessaloniki, G Papanicolau Gen Hosp, Memory & Dementia Ctr, Dept Neurol 3, Thessaloniki, Greece
Soininen, H:
Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland
Hampel, H:
Sorbonne Univ, Pitie Salpetriere Hosp, AP HP, Alzheimer Precis Med AMP,GRC 21, Paris, France
Spiru, L:
Carol Davila Univ Med & Pharm, Bucharest, Romania
Ana Aslan Int Fdn, Alzheimer Unit, Geriatr Gerontol & Old Age Psychiat, Memory Ctr & Longev Med, Bucharest, Romania
Tijms, B:
Maastricht Univ, Alzheimer Ctr Limburg, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, POB 616, NL-6200 MD Maastricht, Netherlands
Ossenkoppele, R:
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Amsterdam UMC,Amsterdam Neurosci, Amsterdam, Netherlands
Lund Univ, Dept Clin Sci, Clin Memory Res Unit, Lund, Sweden
Hosp Clin Barcelona, August Pi & Sunyer Biomed Res Inst IDIBAPS, Neurol Serv, Alzheimers Dis & Other Cognit Disorders Unit, Barcelona, Spain
Verhey, FRJ:
Maastricht Univ, Alzheimer Ctr Limburg, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, POB 616, NL-6200 MD Maastricht, Netherlands
Jessen, F:
Univ Cologne, Dept Psychiat, Cologne, Germany
Deutsch Zentrum Neurodegenerat Erkrankungen eV DZ, German Ctr Neurodegenerat Dis Clin Res, Zentrum Klin Forsch AG, Cologne, Germany
Visser, PJ:
Maastricht Univ, Alzheimer Ctr Limburg, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, POB 616, NL-6200 MD Maastricht, Netherlands
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Amsterdam UMC,Amsterdam Neurosci, Amsterdam, Netherlands
Karolinska Inst, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden
hybrid
|