Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview
Por:
Delaby, C, Teunissen, CE, Blennow, K, Alcolea, D, Arisi, I, Amar, EB, Beaume, A, Bedel, A, Bellomo, G, Bigot-Corbel, E, Bjerke, M, Blanc-Quintin, MC, Boada, M, Bousiges, O, Chapman, MD, DeMarco, ML, D'Onofrio, M, Dumurgier, J, Dufour-Rainfray, D, Engelborghs, S, Esselmann, H, Fogli, A, Gabelle, A, Galloni, E, Gondolf, C, Grandhomme, F, Grau-Rivera, O, Hart, M, Ikeuchi, T, Jeromin, A, Kasuga, K, Keshavan, A, Khalil, M, Kortvelyessy, P, Kulczynska-Przybik, A, Laplanche, JL, Lewczuk, P, Li, QX, Lleo, A, Malaplate, C, Marquie, M, Masters, CL, Mroczko, B, Nogueira, L, Orellana, A, Otto, M, Oudart, JB, Paquet, C, Paoletti, FP, Parnetti, L, Perret-Liaudet, A, Peoc'h, K, Poesen, K, Puig-Pijoan, A, Quadrio, I, Quillard-Muraine, M, Rucheton, B, Schraen, S, Schott, JM, Shaw, LM, Suarez-Calvet, M, Tsolaki, M, Tumani, H, Udeh-Momoh, CT, Vaudran, L, Verbeek, MM, Verde, F, Vermunt, L, Vogelgsang, J, Wiltfang, J, Zetterberg, H, Lehmann, S
Publicada:
1 oct 2022
Ahead of Print:
1 dic 2021
Resumen:
Introduction: The current practice of quantifying cerebrospinal fluid (CSF) biomarkers as an aid in the diagnosis of Alzheimer's disease (AD) varies from center to center. For a same biochemical profile, interpretation and reporting of resultsmay differ, which can lead tomisunderstandings and raises questions about the commutability of tests.
Methods: We obtained a description of (pre-)analytical protocols and sample reports from 40 centers worldwide. A consensus approach allowed us to propose harmonized comments corresponding to the different CSF biomarker profiles observed in patients.
Results: The (pre-)analytical procedures were similar between centers. There was considerable heterogeneity in cutoff definitions and report comments. We therefore identified and selected by consensus the most accurate and informative comments regarding the interpretation of CSF biomarkers in the context of AD diagnosis.
Discussion: This is the first time that harmonized reports are proposed across worldwide specialized laboratories involved in the biochemical diagnosis of AD.
Filiaciones:
Delaby, C:
Univ Montpellier, INSERM, CHU Montpellier, LBPC PPC, Montpellier, France
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, Barcelona, Spain
Teunissen, CE:
Vrije Univ Amsterdam, Dept Clin Chem, Neurochem Lab, Amsterdam UMC,Amsterdam Neurosci, Amsterdam, Netherlands
Blennow, K:
Univ Gothenburg, Inst Neurosci & Physiol, Sahlgrenska Acad, Gothenburg, Sweden
Alcolea, D:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, Barcelona, Spain
Arisi, I:
European Brain Res Inst EBRI Rita Levi Montalcini, Rome, Italy
Amar, EB:
Univ Paris, GHU APHP Nord Lariboisiere Fernand Widal Hosp, Cognit Neurol Ctr, Paris, France
Beaume, A:
CHU Poitiers, Poitiers, France
Bedel, A:
CHU Bordeaux, Bordeaux, France
Bellomo, G:
Univ Perugia, Dept Med & Surg, Sect Neurol, Lab Clin Neurochem, Perugia, Italy
Bigot-Corbel, E:
CHU Nantes, Lab Biochim, Hop G&R Laennec, Nantes, France
Bjerke, M:
Vrije Univ Brussel, Ctr Neurosci, Brussels, Belgium
Univ Ziekenhuis Brussel, Dept Clin Biol, Clin Neurochem Lab, Brussels, Belgium
Univ Antwerp, Inst Born Bunge, Dept Biomed Sci, Antwerp, Belgium
Blanc-Quintin, MC:
APHP Ctr Univ Paris, Cochin Hosp, Paris, France
Boada, M:
Inst Catala Neurociencies Aplicades, Res Ctr, Fundacio ACE, Barcelona, Spain
Inst Catala Neurociencies Aplicades, Memory Clin, Fundacio ACE, Barcelona, Spain
Univ Int Catalunya UIC, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Bousiges, O:
Hop Univ Strasbourg, Lab Biochim & Biol Mol, Strasbourg, France
Hop Univ Strasbourg, CNRS, ICube Lab UMR 7357, Strasbourg, France
Hop Univ Strasbourg, Team IMIS, FMTS Federat Med Translat Strasbourg, Strasbourg, France
Chapman, MD:
UCL Queen Sq, Dept Neuroimmunol, Natl Hosp Neurol & Neurosurg, London, England
DeMarco, ML:
St Pauls Hosp, Dept Pathol & Lab Med, Providence Hlth Care, Vancouver, BC, Canada
Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC, Canada
D'Onofrio, M:
European Brain Res Inst EBRI Rita Levi Montalcini, Rome, Italy
Dumurgier, J:
Univ Paris, GHU APHP Nord Lariboisiere Fernand Widal Hosp, Cognit Neurol Ctr, Paris, France
Dufour-Rainfray, D:
CHU Tours, UMR 1253 iBrain, Tours, France
Engelborghs, S:
Univ Antwerp, Inst Born Bunge, Dept Biomed Sci, Antwerp, Belgium
Vrije Univ Brussel, Univ Ziekenhuis Brussel, Ctr Neurosci, Brussels, Belgium
Vrije Univ Brussel, Univ Ziekenhuis Brussel, Dept Neurol, Brussels, Belgium
Esselmann, H:
Univ Med Ctr Goettingen UMG, Dept Psychiat & Psychotherapy, Gottingen, Germany
Fogli, A:
CHU Clermont Ferrand, Clermont Ferrand, France
Gabelle, A:
Univ Montpellier, INSERM, CHU Montpellier, LBPC PPC, Montpellier, France
Galloni, E:
Dipartimento Neurosci, Div Neurol, Vicenza, Italy
Gondolf, C:
CHU Cote Nacre Caen, Caen, France
Grandhomme, F:
CHU Cote Nacre Caen, Caen, France
Grau-Rivera, O:
Pasqual Maragall Fdn, Barcelonasseta Brain Res Ctr BBRC, Barcelona, Spain
Hosp del Mar, Serv Neurol, Unitat Deteriorament Cognitiu & Transtorns Movime, Barcelona, Spain
IMIM Hosp del Mar Med Res Inst, Barcelona, Spain
Ctr Invest Biomed Red Fragilidad & Envejecimiento, Madrid, Spain
Hart, M:
UCL Queen Sq, Dept Neuroimmunol, Natl Hosp Neurol & Neurosurg, London, England
Ikeuchi, T:
Niigata Univ, Ctr Bioresources, Brain Res Inst, Dept Mol Genet, Niigata, Japan
Jeromin, A:
Cohen Vet Biosci, Cambridge, MA USA
Kasuga, K:
Niigata Univ, Ctr Bioresources, Brain Res Inst, Dept Mol Genet, Niigata, Japan
Keshavan, A:
UCL Queen Sq Inst Neurol, Dementia Res Ctr, London, England
Khalil, M:
Med Univ Graz, Graz, Austria
Kortvelyessy, P:
Free Univ Berlin, Berlin, Germany
Humboldt Univ, Dept Neurol, German Ctr Neurodegenerat Dis, Magdeburg, Germany
Charite Univ Med Berlin, Berlin, Germany
Kulczynska-Przybik, A:
Med Univ Bialystok, Dept Neurodegenerat Diagnost, Bialystok, Poland
Laplanche, JL:
Univ Paris, GHU APHP Nord Lariboisiere Fernand Widal Hosp, Cognit Neurol Ctr, Paris, France
Lewczuk, P:
Med Univ Bialystok, Dept Neurodegenerat Diagnost, Bialystok, Poland
Univ Klinikum Erlangen, Lab Clin Neurochem & Neurochem Dementia Diagnost, Erlangen, Germany
Friedrich Alexander Univ Erlangen Nurnberg, Erlangen, Germany
Li, QX:
Florey Inst, Melbourne, Vic, Australia
Univ Melbourne, Melbourne, Vic, Australia
Lleo, A:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, Barcelona, Spain
Malaplate, C:
Univ Lorraine, Lab Biochim Biol Mol & Nutr, CHRU Nancy, Nancy, France
Marquie, M:
Inst Catala Neurociencies Aplicades, Res Ctr, Fundacio ACE, Barcelona, Spain
Inst Catala Neurociencies Aplicades, Memory Clin, Fundacio ACE, Barcelona, Spain
Univ Int Catalunya UIC, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Masters, CL:
Florey Inst, Melbourne, Vic, Australia
Univ Melbourne, Melbourne, Vic, Australia
Mroczko, B:
Med Univ Bialystok, Dept Neurodegenerat Diagnost, Bialystok, Poland
Nogueira, L:
CHU PURPAN, Lab Biol Cellulaire & Cytol, Toulouse, France
Orellana, A:
Inst Catala Neurociencies Aplicades, Res Ctr, Fundacio ACE, Barcelona, Spain
Inst Catala Neurociencies Aplicades, Memory Clin, Fundacio ACE, Barcelona, Spain
Univ Int Catalunya UIC, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Otto, M:
Univ Ulm, Dept Neurol, Ulm, Germany
Univ Ulm, CSF Lab, Ulm, Germany
Oudart, JB:
Univ Reims, CHU Reims, CNRS UMR 7369, Reims, France
Paquet, C:
Univ Paris, GHU APHP Nord Lariboisiere Fernand Widal Hosp, Cognit Neurol Ctr, Paris, France
Paoletti, FP:
Univ Perugia, Dept Med & Surg, Sect Neurol, Lab Clin Neurochem, Perugia, Italy
Parnetti, L:
Univ Perugia, Dept Med & Surg, Sect Neurol, Lab Clin Neurochem, Perugia, Italy
Perret-Liaudet, A:
Lyon Univ Hosp, Lyon Neurosci Res Ctr, INSERM U1028, BIORAN Team,CNRS UMR 5292, Lyon, France
Peoc'h, K:
Univ Paris, GHU APHP Nord Beaujon Hosp, Paris, France
Poesen, K:
Katholieke Univ Leuven, Dept Neurosci, Lab Mol Neurobiomarker Res LaMoN, Leuven Brain Inst, Leuven, Belgium
Puig-Pijoan, A:
Hosp del Mar, Serv Neurol, Unitat Deteriorament Cognitiu & Transtorns Movime, Barcelona, Spain
IMIM Hosp del Mar Med Res Inst, Barcelona, Spain
Quadrio, I:
Lyon Univ Hosp, Lyon Neurosci Res Ctr, INSERM U1028, BIORAN Team,CNRS UMR 5292, Lyon, France
Quillard-Muraine, M:
Normandie Univ, Rouen Univ Hosp, Dept Clin Biol, Biochem Lab,UNIROUEN, Rouen, France
Rucheton, B:
Sorbonne Univ, AP HP, DMU BioGeM, Paris, France
Schraen, S:
Univ Lille, LabEx DISTALZ, LICEND, CHU Lille,U1172 LilNCog,INSERM, Lille, France
Schott, JM:
UCL Queen Sq Inst Neurol, Dementia Res Ctr, London, England
Shaw, LM:
Univ Penn, Dept Pathol & Lab Med Hosp, Philadelphia, PA 19104 USA
Suarez-Calvet, M:
Pasqual Maragall Fdn, Barcelonasseta Brain Res Ctr BBRC, Barcelona, Spain
Hosp del Mar, Serv Neurol, Unitat Deteriorament Cognitiu & Transtorns Movime, Barcelona, Spain
IMIM Hosp del Mar Med Res Inst, Barcelona, Spain
Ctr Invest Biomed Red Fragilidad & Envejecimiento, Madrid, Spain
Tsolaki, M:
Aristotle Univ Thessaloniki, Fac Hlth Sci, Sch Med, Dept Neurol 1, Thessaloniki, Greece
Tumani, H:
Univ Ulm, Dept Neurol, Ulm, Germany
Univ Ulm, CSF Lab, Ulm, Germany
Udeh-Momoh, CT:
Imperial Coll London, London, England
Vaudran, L:
Univ Lille, CHU Lille, Lille, France
Verbeek, MM:
Radboud Univ Nijmegen, Radboud Alzheimer Ctr, Donders Inst Brain Cognit & Behav, Dept Neurol,Med Ctr, Nijmegen, Netherlands
Radboud Univ Nijmegen, Med Ctr, Dept Lab Med, Nijmegen, Netherlands
Verde, F:
IRCCS Ist Auxol Italiano, Stroke Unit, Dept Neurol, Milan, Italy
IRCCS Ist Auxol Italiano, Lab Neurosci, Milan, Italy
Univ Milan, Dino Ferrari Ctr, Dept Pathophysiol & Transplantat, Milan, Italy
Vermunt, L:
Vrije Univ Amsterdam, Dept Clin Chem, Neurochem Lab, Amsterdam UMC,Amsterdam Neurosci, Amsterdam, Netherlands
Vogelgsang, J:
Univ Med Ctr Goettingen UMG, Dept Psychiat & Psychotherapy, Gottingen, Germany
Harvard Med Sch, McLean Hosp, Translat Neurosci Lab, Belmont, MA USA
Wiltfang, J:
Univ Med Ctr Goettingen UMG, Dept Psychiat & Psychotherapy, Gottingen, Germany
German Ctr Neurodegenerat Dis DZNE, Gottingen, Germany
Univ Aveiro, Inst Biomed iBiMED, Dept Med Sci, Neurosci & Signaling Grp, Aveiro, Portugal
Zetterberg, H:
Univ Gothenburg, Inst Neurosci & Physiol, Sahlgrenska Acad, Gothenburg, Sweden
Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden
UCL, UK Dementia Res Inst, London, England
UCL Inst Neurol, Dept Neurodegenerat Dis, London, England
Lehmann, S:
Univ Montpellier, INSERM, CHU Montpellier, LBPC PPC, Montpellier, France
hybrid, All Open Access, Hybrid Gold
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