Neuropsychiatric Profile as a Predictor of Cognitive Decline in Mild Cognitive Impairment
Por:
Roberto, N, Portella, MJ, Marquie, M, Alegret, M, Hernandez, I, Mauleon, A, Rosende-Roca, M, Abdelnour, C, de Antonio, EE, Tartari, JP, Vargas, L, Lopez-Cuevas, R, Bojaryn, U, Espinosa, A, Ortega, G, Perez-Cordon, A, Sanabria, A, Orellana, A, de Rojas, I, Moreno-Grau, S, Montrreal, L, Alarcon-Martin, E, Ruiz, A, Tarraga, L, Boada, M, Valero, S
Publicada:
8 dic 2021
Resumen:
Introduction: Mild cognitive impairment is often associated with affective and other neuropsychiatric symptoms (NPS). This co-occurrence might have a relevant impact on disease progression, from MCI to dementia.Objective: The aim of this study was to explore the trajectories of cognitive decline in an MCI sample from a memory clinic, taking into consideration a perspective of isolated cognitive functions and based on NPS clusters, accounting for the different comorbid symptoms collected at their baseline visit.Methods: A total of 2,137 MCI patients were monitored over a 2.4-year period. Four clusters of NPS (i.e., Irritability, Apathy, Anxiety/Depression and Asymptomatic) were used to run linear mixed models to explore the interaction of cluster with time on cognitive trajectories using a comprehensive neuropsychological battery (NBACE) administered at baseline and at the three subsequent follow-ups.Results: A significant interaction between cluster and time in cognitive decline was found when verbal learning and cued-recall were explored (p = 0.002 for both memory functions). For verbal learning, the Irritability cluster had the largest effect size (0.69), whereas the Asymptomatic cluster showed the smallest effect size (0.22). For cued-recall, the Irritability cluster had the largest effect size among groups (0.64), and Anxiety/Depression had the smallest effect size (0.21).Conclusions: In MCI patients, the Irritability and Apathy NPS clusters shared similar patterns of worsening in memory functioning, which could point to these NPS as risk factors of a faster cognitive decline, acting as early prognostic markers and helping in the diagnostic process.
Filiaciones:
Roberto, N:
Univ Int Catalunya UIC, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Univ Autonoma Barcelona UAB, Dept Psychiat & Forens Med, Barcelona, Spain
Portella, MJ:
Univ Autonoma Barcelona UAB, Dept Psychiat & Forens Med, Barcelona, Spain
Hosp Santa Creu & Sant Pau, Inst Invest Biomed St Pau IIB St Pau, Dept Psychiat, Barcelona, Spain
Networking Res Ctr Mental Hlth CIBERSAM, Madrid, Spain
Marquie, M:
Univ Int Catalunya UIC, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid, Spain
Alegret, M:
Univ Int Catalunya UIC, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid, Spain
Hernandez, I:
Univ Int Catalunya UIC, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid, Spain
Mauleon, A:
Univ Int Catalunya UIC, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Rosende-Roca, M:
Univ Int Catalunya UIC, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Abdelnour, C:
Univ Int Catalunya UIC, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid, Spain
de Antonio, EE:
Univ Int Catalunya UIC, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Tartari, JP:
Univ Int Catalunya UIC, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Vargas, L:
Univ Int Catalunya UIC, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Lopez-Cuevas, R:
Univ Int Catalunya UIC, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Bojaryn, U:
Univ Int Catalunya UIC, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Espinosa, A:
Univ Int Catalunya UIC, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid, Spain
Ortega, G:
Univ Int Catalunya UIC, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid, Spain
Perez-Cordon, A:
Univ Int Catalunya UIC, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Sanabria, A:
Univ Int Catalunya UIC, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid, Spain
Orellana, A:
Univ Int Catalunya UIC, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Univ Autonoma Barcelona UAB, Dept Psychiat & Forens Med, Barcelona, Spain
de Rojas, I:
Univ Int Catalunya UIC, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Moreno-Grau, S:
Univ Int Catalunya UIC, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Montrreal, L:
Univ Int Catalunya UIC, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Alarcon-Martin, E:
Univ Int Catalunya UIC, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Ruiz, A:
Univ Int Catalunya UIC, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid, Spain
Tarraga, L:
Univ Int Catalunya UIC, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid, Spain
Boada, M:
Univ Int Catalunya UIC, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid, Spain
Valero, S:
Univ Int Catalunya UIC, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid, Spain
Green Published, gold
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