Neonatal Immune Neutropenia due to Isoantibodies against the Granulocyte Receptor Fc gamma RIIIb


Por: Del Barrio, BV, Maya-Enero, S, Rodriguez-Sevilla, JJ, Suris, CC, Llobet, AB, Lopez-Vilchez, MA

Publicada: 1 ago 2021 Ahead of Print: 1 feb 2021
Resumen:
Introduction: Neonatal neutropenia is often secondary to sepsis, low birth weight, pregnancy-induced maternal hypertension, and other conditions. Case Report: We report a case of asymptomatic isoimmune neutropenia in a pair of preterm twins. Genotyping confirmed that the mother was negative for HNA-1a, 1b, and 1c, consistent with an Fc gamma RIIIb deficiency. The father was 1(a+b+c-) and the neonates were 1(a-b+c-). A strongly positive result was observed in the granulocyte immunofluorescence test against paternal neutrophils (IgG antibodies). IgG anti-CD16b isoantibodies were detected in the mother's breast milk. Neutropenia resolved after 28 days without requiring any specific treatments. Discussion: Even though neonatal alloimmune neutropenia (NAN) is usually benign and self-limiting, some patients pre-sent with delayed separation of the umbilical cord, mild skin infections, omphalitis, or severe infections like pneumonia, sepsis, and meningitis. Thus, it is important to rule out NAN in case of neonatal neutropenia.

Filiaciones:
Del Barrio, BV:
 Univ Autonoma Barcelona, Hosp Mar, Serv Pediat, Dept Neonatol, Passeig Maritim 25-29, ES-08003 Barcelona, Spain

Maya-Enero, S:
 Univ Autonoma Barcelona, Hosp Mar, Serv Pediat, Dept Neonatol, Passeig Maritim 25-29, ES-08003 Barcelona, Spain

Rodriguez-Sevilla, JJ:
 Univ Autonoma Barcelona, Hosp Mar, Serv Hematol, Barcelona, Spain

Suris, CC:
 Blood & Tissue Bank, Immunohematol Lab, Barcelona, Spain

Llobet, AB:
 Hosp Mar, Transfus Serv, Barcelona, Spain

 Blood & Tissue Bank, Barcelona, Spain

Lopez-Vilchez, MA:
 Univ Autonoma Barcelona, Hosp Mar, Serv Pediat, Dept Neonatol, Passeig Maritim 25-29, ES-08003 Barcelona, Spain
ISSN: 16603796





TRANSFUSION MEDICINE AND HEMOTHERAPY
Editorial
KARGER, ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND, Suiza
Tipo de documento: Article
Volumen: 48 Número: 4
Páginas: 259-262
WOS Id: 000625244000001
ID de PubMed: 34539322
imagen gold, Green Published

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