Neonatal Immune Neutropenia due to Isoantibodies against the Granulocyte Receptor Fc gamma RIIIb
Por:
Del Barrio, BV, Maya-Enero, S, Rodriguez-Sevilla, JJ, Suris, CC, Llobet, AB, Lopez-Vilchez, MA
Publicada:
1 ago 2021
Ahead of Print:
1 feb 2021
Resumen:
Introduction: Neonatal neutropenia is often secondary to sepsis, low birth weight, pregnancy-induced maternal hypertension, and other conditions. Case Report: We report a case of asymptomatic isoimmune neutropenia in a pair of preterm twins. Genotyping confirmed that the mother was negative for HNA-1a, 1b, and 1c, consistent with an Fc gamma RIIIb deficiency. The father was 1(a+b+c-) and the neonates were 1(a-b+c-). A strongly positive result was observed in the granulocyte immunofluorescence test against paternal neutrophils (IgG antibodies). IgG anti-CD16b isoantibodies were detected in the mother's breast milk. Neutropenia resolved after 28 days without requiring any specific treatments. Discussion: Even though neonatal alloimmune neutropenia (NAN) is usually benign and self-limiting, some patients pre-sent with delayed separation of the umbilical cord, mild skin infections, omphalitis, or severe infections like pneumonia, sepsis, and meningitis. Thus, it is important to rule out NAN in case of neonatal neutropenia.
Filiaciones:
Del Barrio, BV:
Univ Autonoma Barcelona, Hosp Mar, Serv Pediat, Dept Neonatol, Passeig Maritim 25-29, ES-08003 Barcelona, Spain
Maya-Enero, S:
Univ Autonoma Barcelona, Hosp Mar, Serv Pediat, Dept Neonatol, Passeig Maritim 25-29, ES-08003 Barcelona, Spain
Rodriguez-Sevilla, JJ:
Univ Autonoma Barcelona, Hosp Mar, Serv Hematol, Barcelona, Spain
Suris, CC:
Blood & Tissue Bank, Immunohematol Lab, Barcelona, Spain
Llobet, AB:
Hosp Mar, Transfus Serv, Barcelona, Spain
Blood & Tissue Bank, Barcelona, Spain
Lopez-Vilchez, MA:
Univ Autonoma Barcelona, Hosp Mar, Serv Pediat, Dept Neonatol, Passeig Maritim 25-29, ES-08003 Barcelona, Spain
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