Biomarkers of coagulation and fibrinolysis in acute myocardial infarction: a joint position paper of the Association for Acute Cardio Vascular Care and the European Society of Cardiology Working Group on Thrombosis
Por:
Krychtiuk, KA, Speidl, WS, Giannitsis, E, Gigante, B, Gorog, DA, Jaffe, AS, Mair, J, Mockel, M, Mueller, C, Storey, RF, Vilahur, G, Wojta, J, Huber, K, Halvorsen, S, Geisler, T, Morais, J, Lindahl, B, Thygesen, K
Publicada:
1 mar 2021
Resumen:
The formation of a thrombus in an epicardial artery may result in an acute myocardial infarction (AMI). Despite major advances in acute treatment using network approaches to allocate patients to timely reperfusion and optimal antithrombotic treatment, patients remain at high risk for thrombotic complications. Ongoing activation of the coagulation system as well as thrombin-mediated platelet activation may both play a crucial role in this context. Whether measurement of circulating biomarkers of coagulation and fibrinolysis could be useful for risk stratification in secondary prevention is currently not fully understood. In addition, measurement of such biomarkers could be helpful to identify thrombus formation as the leading mechanism for AMI. The introduction of biomarkers of myocardial injury such as high-sensitivity cardiac troponins made rule-out of AMI even more precise. However, elevated markers of myocardial injury cannot provide proof of a type 1 AMI, let alone thrombus formation. The combined measurement of markers of myocardial injury with biomarkers reflecting ongoing thrombus formation might be helpful for the fast and correct diagnosis of an atherothrombotic type 1 AMI. This position paper gives an overview of the current knowledge and possible role of biomarkers of coagulation and fibrinolysis for the diagnosis of AMI, risk stratification, and individualized treatment strategies in patients with AMI.
Filiaciones:
Krychtiuk, KA:
Med Univ Vienna, Dept Internal Med 2, Div Cardiol, Waehringer Guertel 18-20, A-1090 Vienna, Austria
Speidl, WS:
Med Univ Vienna, Dept Internal Med 2, Div Cardiol, Waehringer Guertel 18-20, A-1090 Vienna, Austria
Giannitsis, E:
Med Univ Heidelberg, Dept Internal Med 3, Pulmonol, Cardiol,Angiol, Neuenheimer Feld 672, D-69120 Heidelberg, Germany
Gigante, B:
Karolinska Inst, Dept Med, Unit Cardiovasc Med, Solnavagen 1, S-17177 Solna, Sweden
Danderyd Hosp, Dept Clin Sci, Entrevagen 2, S-18257 Danderyd, Sweden
Gorog, DA:
Imperial Coll, Natl Heart & Lung Inst, Dept Med, Guy Scadding Bldg,Dovehouse St, London SW3 6LY, England
Univ Hertfordshire, Postgrad Med Sch, Hatfield, Herts, England
Jaffe, AS:
Mayo Clin, Dept Cardiol, 1216 2nd St SW, Rochester, MN 55902 USA
Mayo Clin, Dept Lab Med & Pathol, 1216 2nd St SW, Rochester, MN 55902 USA
Mair, J:
Med Univ Innsbruck, Dept Internal Med Cardiol & Angiol 3, Anichstr 35, A-6020 Innsbruck, Austria
Mockel, M:
Charite Univ Med Berlin, Div Emergency & Acute Med, Campus Mitte & Virchow,Augustenburger Pl 1, D-13353 Berlin, Germany
Charite Univ Med Berlin, Chest Pain Units, Campus Mitte & Virchow,Augustenburger Pl 1, D-13353 Berlin, Germany
Mueller, C:
Univ Basel, Univ Hosp Basel, Cardiovasc Res Inst Basel CRIB, Spitalstr 2, CH-4056 Basel, Switzerland
Storey, RF:
Univ Sheffield, Med Sch, Dept Infect Immun & Cardiovasc Dis, Cardiovasc Res Unit, Beech Hill Rd, Sheffield S10 2RX, S Yorkshire, England
Vilahur, G:
IIB St Pau, Res Inst Hosp Santa Creu & St Pau, Cardiovasc Program ICCC, Carrer St Quinti 89, Barcelona 08041, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Cardiovasc CIBERCV, Calle Melchor Fernandez Almagro 3, Madrid 28029, Spain
Wojta, J:
Med Univ Vienna, Dept Internal Med 2, Div Cardiol, Waehringer Guertel 18-20, A-1090 Vienna, Austria
Ludwig Boltzmann Inst Cardiovasc Res, Waehringer Guertel 18-20, A-1090 Vienna, Austria
Huber, K:
Ludwig Boltzmann Inst Cardiovasc Res, Waehringer Guertel 18-20, A-1090 Vienna, Austria
Wilhelminenhospital, Med Dept Cardiol & Intens Care Med 3, Montleartstr 37, A-1160 Vienna, Austria
Halvorsen, S:
Univ Oslo, Oslo Univ Hosp Ulleval, Dept Cardiol, Kirkeveien 166, N-0450 Oslo, Norway
Geisler, T:
Univ Hosp Tubingen, Hoppe Seyler Str 3, D-72076 Tubingen, Germany
Morais, J:
Santo Andres Hosp, Div Cardiol, P-2410197 Leiria, Portugal
Lindahl, B:
Uppsala Univ, Uppsala Clin Res Ctr, Dept Med Sci, Dag Hammarskjolds Vag 38, S-75185 Uppsala, Sweden
Thygesen, K:
Aarhus Univ Hosp, Dept Cardiol, Palle Juul Jensens Blvd 161, DK-8200 Aarhus N, Denmark
Bronze
|