Effectiveness and safety of methotrexate monotherapy in patients with Crohn's disease refractory to anti-TNF-alpha: results from the ENEIDA registry
Por:
Mesonero, F, Castro-Poceiro, J, Benitez, JM, Camps, B, Iborra, M, Lopez-Garcia, A, Torres, P, Esteve, M, Tosca, J, Bertoletti, F, Almela, P, Calvet, X, Vera, I, Bujanda, L, Gomollon, F, Rodriguez, C, Antolin, B, Busquets, D, Hernandez, A, Rivero, M, Miquel, DMI, Castano-Garcia, A, Gisbert, JP, Domenech, E, Lopez-Sanroman, A
Publicada:
1 may 2021
Ahead of Print:
1 mar 2021
Resumen:
Background Methotrexate can be used to maintain remission in Crohn's disease patients who are intolerant to thiopurines. Data on its use as monotherapy in other scenarios are limited.
Aim To assess the effectiveness of methotrexate monotherapy in Crohn's disease patients after previous failure to anti-tumour necrosis factor (anti-TNF alpha) drugs.
Methods A retrospective, observational multicentre study of data from the Spanish ENEIDA registry. Participants were patients with active Crohn's disease and previous failure to anti-TNF alpha started on methotrexate monotherapy. Short-term effectiveness was assessed at 12-16 weeks based on Harvey-Bradshaw index (HBI): clinical remission as HBI <= 3 points and clinical response as HBI drop of >= 3 points over baseline. Long-term effectiveness was defined as steroid-free methotrexate persistence from 12 to 16 weeks until maximum follow up. Adverse events were recorded.
Results Data were compiled for 110 patients treated with methotrexate after a failed response to one (39%) or two (55.6%) anti-TNF alpha agents. Short-term clinical response and remission rates were 60% and 30.9% respectively. Of 74 patients who continued after week 16, long-term effectiveness was achieved in 82% and 74% at 12 and 24 months respectively. In the multivariate analysis, non-remission at short term (vs remission) was associated with long-term failure (HR 2.58, 95%CI 1.95-3.68, P = 0.028). Adverse events (evaluated in 100 patients) were recorded in 44%, and in 30.4% of these patients, they led to methotrexate discontinuation.
Conclusions The benefits observed suggest methotrexate monotherapy could be a valid option in Crohn's disease patients with previous failure to anti-TNF alpha.
Filiaciones:
Mesonero, F:
Hosp Univ Ramon y Cajal, HOS, Madrid, Spain
Castro-Poceiro, J:
Hosp Clin Barcelona, Barcelona, Spain
IDIBAPS, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain
Benitez, JM:
Hosp Reina Sofia, Cordoba, Spain
Camps, B:
Hosp Univ Bellvitge, Barcelona, Spain
Iborra, M:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain
5Hosp Univ & Politecn La Fe, Valencia, Spain
Lopez-Garcia, A:
Hosp del Mar, Barcelona, Spain
IMIM, Barcelona, Spain
Torres, P:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain
Hosp Badalona Germans Trias & Pujol, Barcelona, Spain
Esteve, M:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain
Hosp Univ Mutua Terrassa, Barcelona, Spain
Tosca, J:
Hosp Clin Valencia, Valencia, Spain
Bertoletti, F:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Almela, P:
Hosp Gen Univ Castellon, Castellon de La Plana, Spain
Calvet, X:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain
Hosp Univ Parc Tauli, Sabadell, Spain
Vera, I:
Hosp Univ Puerta Hierro Majadahonda, Dept Gastroenterol, Madrid, Spain
Bujanda, L:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain
Hosp Univ Donostia, San Sebastian, Spain
Gomollon, F:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain
Hosp Clin Univ Lozano Blesa, Zaragoza, Spain
Rodriguez, C:
Complejo Hosp Navarra, Pamplona, Spain
Antolin, B:
Hosp Clin Univ Valladolid, Valladolid, Spain
Busquets, D:
Hosp Univ Doctor Trueta, Girona, Spain
Hernandez, A:
Hosp Univ Nuestra Senora Candelaria, Tenerife, Spain
Rivero, M:
Hosp Univ Marques Valdecilla, Santander, Spain
IDIVAL, Santander, Spain
Miquel, DMI:
Consorci Sanitari Terrassa, Barcelona, Spain
Castano-Garcia, A:
Hosp Univ Cent Asturias, Asturias, Spain
Gisbert, JP:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain
Univ Autonoma Madrid UAM, Inst Invest Sanitaria Princesa IIS IP, Hosp Univ La Princesa, Madrid, Spain
Lopez-Sanroman, A:
Hosp Univ Ramon y Cajal, HOS, Madrid, Spain
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