Endothelial Progenitor Cell Function in Patients With Coronary Chronic Total Occlusion and its Relationship With Collateral Circulation
Por:
Flores-Umanzor, EJ, Ortega-Paz, L, Cepas-Guillen, PL, Giacchi, G, Padro, T, Badimon, L, Sabate, M, Brugaletta, S
Publicada:
1 oct 2021
Resumen:
Aim. To evaluate the relationship between endothelial progenitor cell (EPC) count and function and collateral circulation in coronary chronic total occlusions (CTOs). Methods. A total of 20 consecutive patients with successfully treated CTO lesions were included during a period of 12 months. EPC count and function were evaluated by flow cytometry and colony-forming unit (CFU) analysis at baseline (before percutaneous coronary intervention) and at 1-year follow-up. Patients were classified, according to Rentrop classification at the baseline angiography, as group 1 (Rentrop 3; n = 7) and group 2 (Rentrop <3; n = 13). Differences in EPC count and function were compared between groups. Results. The EPC count did not differ between the 2 groups, either at baseline or at follow-up. CFU was significantly lower at follow-up compared with baseline in the overall population (16.6 106/mL (IQR, 10.2-29.4 106/mL) vs 7.1 106/mL (IQR, 5.3-25.0 106/mL); P=.046). Group 1 had both higher basal and follow-up CFU values compared with group 2 (35.4 106/mL (IQR, 21.5-41.8 106/mL) vs 13.3 106/mL (IQR, 6.9-17.5 106/mL) and 32.1 106/mL (IQR, 13.9-40.5 106/mL) vs 5.9 106/mL (IQR, 4.4-9.8 106/mL), respectively; P=.01 for both). By linear regression analysis, Rentrop grade 3 flow was an independent predictor of both basal and follow-up CFU levels (odds ratio, 3.66; 95% confidence interval, 6.41-29.69; P<.01; and odds ratio, 5.24; 95% confidence interval, 9.78-25.85; P<.01, respectively). Conclusion. Patients with Rentrop grade 3 collateral circulation exhibited higher EPC activity at baseline and at 1-year follow-up compared with those who had reduced collateral circulation. The role of this higher EPC activity in determining clinical endpoint should be investigated in a larger study.
Filiaciones:
Flores-Umanzor, EJ:
IDIBAPS, Clin Cardiovasc Inst, Cardiol Dept, Hosp Clin, Barcelona, Spain
Ortega-Paz, L:
IDIBAPS, Clin Cardiovasc Inst, Cardiol Dept, Hosp Clin, Barcelona, Spain
Cepas-Guillen, PL:
IDIBAPS, Clin Cardiovasc Inst, Cardiol Dept, Hosp Clin, Barcelona, Spain
Giacchi, G:
IDIBAPS, Clin Cardiovasc Inst, Cardiol Dept, Hosp Clin, Barcelona, Spain
Padro, T:
Hosp Santa Creu & Sant Pau, IIB St Pau, Cardiovasc Sci Inst ICCC, Barcelona, Spain
Badimon, L:
Hosp Santa Creu & Sant Pau, IIB St Pau, Cardiovasc Sci Inst ICCC, Barcelona, Spain
Sabate, M:
IDIBAPS, Clin Cardiovasc Inst, Cardiol Dept, Hosp Clin, Barcelona, Spain
Brugaletta, S:
IDIBAPS, Clin Cardiovasc Inst, Cardiol Dept, Hosp Clin, Barcelona, Spain
Open Access
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