Effectiveness of maternal pertussis vaccination in protecting newborn: A matched case-control study
Por:
Godoy, P, Garcia-Cenoz, M, Rius, C, Munoz-Almagro, C, Carmona, G, Alseda, M, Jane, M, Vidal, MJ, Rodriguez, R, Alvarez, J, Camps, N, Minguell, S, Carol, M, Sala, MR, Castilla, J, Dominguez, A
Publicada:
1 nov 2021
Ahead of Print:
1 nov 2021
Resumen:
Introduction: The objective was to estimate the effectiveness of maternal pertussis vaccination in protecting infants aged < 2 months. Methods: We performed a case-control study. Laboratory-confirmed cases aged < 8 weeks at disease onset were identified and 2-4 matched-controls born within +/- 15 days of the case were included. Information was obtained from healthcare providers and maternal interviews. Odds ratios (OR) were calculated using multivariable conditional logistic regression. Vaccine effectiveness (VE) was estimated as (1 - OR) x 100%. Results: 47 cases and 124 controls were studied. The mean age (in days) (39.8 +/- 12.7 vs. 40.8 +/- 13.2), weeks of gestation (38.8 vs. 39.1, p = 0.43) and mean birth weight (3.309 vs. 3.253 kg, p = 0.55) were comparable between cases and controls. Mothers of cases were less frequently vaccinated in the third trimester (59.6% vs. 83.9%, p < 0.001). The VE of maternal vaccination in pregnancy was 88.0% (95%CI 53.8%-96.5%), and was slightly higher in those vaccinated before the 32nd week of gestation (88.5% vs 87.8%). Conclusion: Pertussis vaccination in pregnancy is very effective in reducing pertussis in children aged < 2 months. Vaccination before and after the 32nd week of pregnancy are equally effective in reducing the risk of pertussis. (c) 2021 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
Filiaciones:
Godoy, P:
Agencia Salut Publ Catalunya, Barcelona, Spain
IRBLLEIDA, Inst Recerca Biomed Lleida, Lleida, Spain
CIBERESP, CIBER Epidemiol & Salud Publ, Madrid, Spain
Garcia-Cenoz, M:
CIBERESP, CIBER Epidemiol & Salud Publ, Madrid, Spain
Inst Salud Publ Navarra IdiSNA, Pamplona, Spain
Rius, C:
Agencia Salut Publ Barcelona, Barcelona, Spain
CIBERESP, CIBER Epidemiol & Salud Publ, Madrid, Spain
Munoz-Almagro, C:
Hosp St Joan de Deu, Inst Recerca Pediat, Barcelona, Spain
Univ Int Catalunya, Dept Med, Barcelona, Spain
CIBERESP, CIBER Epidemiol & Salud Publ, Madrid, Spain
Carmona, G:
Agencia Salut Publ Catalunya, Barcelona, Spain
Alseda, M:
IRBLLEIDA, Inst Recerca Biomed Lleida, Lleida, Spain
Agencia Salut Publ Catalunya, Barcelona, Spain
Jane, M:
CIBERESP, CIBER Epidemiol & Salud Publ, Madrid, Spain
Agencia Salut Publ Catalunya, Barcelona, Spain
Vidal, MJ:
Agencia Salut Publ Catalunya, Barcelona, Spain
Rodriguez, R:
Agencia Salut Publ Catalunya, Barcelona, Spain
Alvarez, J:
Agencia Salut Publ Catalunya, Barcelona, Spain
Camps, N:
Agencia Salut Publ Catalunya, Barcelona, Spain
Minguell, S:
Agencia Salut Publ Catalunya, Barcelona, Spain
Carol, M:
Agencia Salut Publ Catalunya, Barcelona, Spain
Sala, MR:
Agencia Salut Publ Catalunya, Barcelona, Spain
Castilla, J:
CIBERESP, CIBER Epidemiol & Salud Publ, Madrid, Spain
Inst Salud Publ Navarra IdiSNA, Pamplona, Spain
Dominguez, A:
Univ Barcelona, Dept Med, Barcelona, Spain
CIBERESP, CIBER Epidemiol & Salud Publ, Madrid, Spain
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