The unexplored role of sedentary time and physical activity in glucose and lipid metabolism-related placental mRNAs in pregnant women who are obese: the DALI lifestyle randomised controlled trial
Por:
Acosta-Manzano, P, Leopold-Posch, B, Simmons, D, Devlieger, R, Galjaard, S, Corcoy, R, Adelantado, JM, Dunne, F, Harreiter, J, Kautzky-Willer, A, Damm, P, Mathiesen, ER, Jensen, DM, Andersen, LL, Tanvig, M, Lapolla, A, Dalfra, MG, Bertolotto, A, Wender-Ozegowska, E, Zawiejska, A, Hill, DJ, Snoek, FJ, Jelsma, JGM, Desoye, G, van Poppel, MNM
Publicada:
1 abr 2022
Ahead of Print:
1 nov 2021
Resumen:
Objective We aimed to explore: (i) the association of sedentary time (ST) and physical activity (PA) during pregnancy with the placental expression of genes related to glucose and lipid metabolism in pregnant women who are obese; (ii) maternal metabolic factors mediating changes in these placental transcripts; and (iii) cord blood markers related to the mRNAs mediating neonatal adiposity. Design Multicentre randomised controlled trial. Setting Hospitals in nine European countries. Population A cohort of 112 pregnant women with placental tissue. Methods Both ST and moderate-to-vigorous PA (MVPA) levels were measured objectively using accelerometry at three time periods during pregnancy. Main outcome measures Placental mRNAs (FATP2, FATP3, FABP4, GLUT1 and PPAR-gamma) were measured with NanoString technology. Maternal and fetal metabolic markers and neonatal adiposity were assessed. Results Longer periods of ST, especially in early to middle pregnancy, was associated with lower placental FATP2 and FATP3 expression (P < 0.05), whereas MVPA at baseline was inversely associated with GLUT1 mRNA (P = 0.02). Although placental FATP2 and FATP3 expression were regulated by the insulin-glucose axis (P < 0.05), no maternal metabolic marker mediated the association of ST/MVPA with placental mRNAs (P > 0.05). Additionally, placental FATP2 expression was inversely associated with cord blood triglycerides and free fatty acids (FFAs; P < 0.01). No cord blood marker mediated neonatal adiposity except for cord blood leptin, which mediated the effects of PPAR-gamma on neonatal sum of skinfolds (P < 0.05). Conclusions In early to middle pregnancy, ST is associated with the expression of placental genes linked to lipid transport. PA is hardly related to transporter mRNAs. Strategies aimed at reducing sedentary behaviour during pregnancy could modulate placental gene expression, which may help to prevent unfavourable fetal and maternal pregnancy outcomes. Tweetable abstract Reducing sedentary behaviour in pregnancy might modulate placental expression of genes related to lipid metabolism in women who are obese.
Filiaciones:
Acosta-Manzano, P:
Univ Granada, Sport & Hlth Univ Res Inst iMUDS, CTS Res Grp 1018, PA HELP Phys Act Hlth Promot, Granada, Spain
Univ Granada, Fac Sports Sci, Dept Phys Educ & Sports, Carretera Alfacar S-N, Granada, Spain
Leopold-Posch, B:
Med Univ Graz, Dept Obstet & Gynaecol, Graz, Austria
Simmons, D:
Western Sydney Univ, Campbelltown, NSW, Australia
Devlieger, R:
Katholieke Univ Leuven, Univ Hosp Leuven, Dept Dev & Regenerat Pregnancy Fetus & Neonate Gy, Leuven, Belgium
Galjaard, S:
Katholieke Univ Leuven, Univ Hosp Leuven, Dept Dev & Regenerat Pregnancy Fetus & Neonate Gy, Leuven, Belgium
Erasmus MC, Univ Med Ctr Rotterdam, Dept Obstet & Gynaecol, Div Obstet & Prenatal Med, Rotterdam, Netherlands
Corcoy, R:
Inst Salud Carlos III, CIBER Bioengn Biomat & Nanomed, Zaragoza, Spain
Hosp Santa Creu & Sant Pau, Inst Recerca, Barcelona, Spain
Adelantado, JM:
Hosp Santa Creu & Sant Pau, Inst Recerca, Barcelona, Spain
Dunne, F:
Galway Diabet Res Ctr GDRC, Galway, Ireland
Natl Univ Ireland, Galway, Ireland
Harreiter, J:
Med Univ Vienna, Dept Internal Med 3, Gender Med Unit, Endocrinol & Metab, Vienna, Austria
Kautzky-Willer, A:
Med Univ Vienna, Dept Internal Med 3, Gender Med Unit, Endocrinol & Metab, Vienna, Austria
Damm, P:
Univ Copenhagen, Rigshosp, Dept Endocrinol, Copenhagen, Denmark
Univ Copenhagen, Rigshosp, Dept Obstet, Copenhagen, Denmark
Univ Copenhagen, Ctr Pregnant Women Diabet, Dept Clin Med, Copenhagen, Denmark
Mathiesen, ER:
Univ Copenhagen, Rigshosp, Dept Endocrinol, Copenhagen, Denmark
Univ Copenhagen, Rigshosp, Dept Obstet, Copenhagen, Denmark
Univ Copenhagen, Ctr Pregnant Women Diabet, Dept Clin Med, Copenhagen, Denmark
Jensen, DM:
Odense Univ Hosp, Steno Diabet Ctr Odense, Odense, Denmark
Odense Univ Hosp, Dept Obstet & Gynaecol, Odense, Denmark
Univ Southern Denmark, Dept Clin Res, Fac Hlth Sci, Odense, Denmark
Andersen, LL:
Odense Univ Hosp, Dept Obstet & Gynaecol, Odense, Denmark
Univ Southern Denmark, Dept Clin Res, Fac Hlth Sci, Odense, Denmark
Tanvig, M:
Odense Univ Hosp, Dept Obstet & Gynaecol, Odense, Denmark
Univ Southern Denmark, Dept Clin Res, Fac Hlth Sci, Odense, Denmark
Lapolla, A:
Univ Padua, Dept Med & Surg Sci, Padua, Italy
Dalfra, MG:
Univ Padua, Dept Med & Surg Sci, Padua, Italy
Bertolotto, A:
Univ Pisa, Dept Clin & Expt Med, Pisa, Italy
Wender-Ozegowska, E:
Poznan Univ Med Sci, Dept Reprod, Poznan, Poland
Zawiejska, A:
Poznan Univ Med Sci, Dept Med Simulat, Chair Med Educ, Poznan, Poland
Hill, DJ:
Lawson Hlth Res Inst, London, ON, Canada
Snoek, FJ:
Vrije Univ Amsterdam, Amsterdam Univ, Med Ctr, Dept Med Psychol,Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands
Jelsma, JGM:
Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Publ Hlth Res Inst, Dept Publ & Occupat Hlth, Amsterdam, Netherlands
Desoye, G:
Med Univ Graz, Dept Obstet & Gynaecol, Graz, Austria
van Poppel, MNM:
Graz Univ, Inst Human Movement Sci Sport & Hlth, Graz, Austria
hybrid, Green Published
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